Abstract：
:We previously showed the possibility that Gag A146P, which is an escape mutant from HLA-B∗57-restricted CTLs, was selected by HLA-B∗48:01-restricted Gag138-147(LI10)-specific CTLs in a Japanese cohort in which HLA-B∗57 individuals were not detected. We herein demonstrated Gag140-147(GI8) to be the optimal epitope rather than LI10 and that GI8-specific T cells failed to recognize the A146P mutant virus-infected cells. The sequence analysis of Gag146 in 261 chronically HIV-1-infected Japanese showed the accumulation of the A146P mutation in HLA-B∗48:01(+) individuals. These findings together indicate that the A146P mutant is accumulating in Japanese by selection by GI8-specific CTLs.
journal_name
Microbes Infectjournal_title
Microbes and infectionauthors
Naruto T,Murakoshi H,Chikata T,Koyanagi M,Kawashima Y,Gatanaga H,Oka S,Takiguchi Mdoi
10.1016/j.micinf.2011.03.009subject
Has Abstractpub_date
2011-08-01 00:00:00pages
766-70issue
8-9eissn
1286-4579issn
1769-714Xpii
S1286-4579(11)00092-Xjournal_volume
13pub_type
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