Abstract:
:Eleven new cases of visceral leishmaniasis (VL) are reported in organ transplant patients in France. The epidemiological, clinical, biological, diagnostic and therapeutic features are reviewed, based on these cases and 46 cases reported in the literature. VL was most commonly associated with renal transplantation (77% of the cases). Most patients were from Southern European countries. The main clinical symptom was fever. Leucopoenia and anaemia were the most frequent haematological disorders. Diagnosis was by direct finding of the parasite in smears of bone marrow (85.2%) or, by positive serology (90.9%). Without antileishmanial treatment, VL in transplant recipients was fatal. Treatment using either antimonials or amphotericine B gave similar cure rates of around 80% of the cases. But toxicity was higher for antimonials. Relapses occurred in 14.3%.
journal_name
Microbes Infectjournal_title
Microbes and infectionauthors
Basset D,Faraut F,Marty P,Dereure J,Rosenthal E,Mary C,Pratlong F,Lachaud L,Bastien P,Dedet JPdoi
10.1016/j.micinf.2005.06.002subject
Has Abstractpub_date
2005-10-01 00:00:00pages
1370-5issue
13eissn
1286-4579issn
1769-714Xpii
S1286-4579(05)00191-7journal_volume
7pub_type
杂志文章,评审abstract::Despite high vaccination coverage, pertussis remains an important respiratory infectious disease and the least-controlled vaccine-preventable infectious disease in children. Natural infection with Bordetella pertussis is known to induce strong and long-lasting immunity that wanes later than vaccine-mediated immunity. ...
journal_title:Microbes and infection
pub_type: 杂志文章
doi:10.1016/j.micinf.2013.10.002
更新日期:2014-01-01 00:00:00
abstract::Flaviviruses enter their host cells by receptor-mediated endocytosis, a well-orchestrated process of receptor recognition, penetration and uncoating. Recent findings on these early steps in the life cycle of flaviviruses are the focus of this review. ...
journal_title:Microbes and infection
pub_type: 杂志文章,评审
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journal_title:Microbes and infection
pub_type: 杂志文章
doi:10.1016/j.micinf.2007.10.002
更新日期:2008-01-01 00:00:00
abstract::The differentiation and survival of developing alpha beta thymocytes depends on effective T-cell receptor (TCR) signaling upon recognition of self peptide/major histocompatibility complex (MHC) molecule ligands. Although this concept is uniformly accepted with regard to immature thymocytes, there are conflicting repor...
journal_title:Microbes and infection
pub_type: 杂志文章,评审
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abstract::Autoantibodies against various components of host are known to occur in leprosy. Nerve damage is the primary cause of disability associated with leprosy. The aim of this study was to detect the level of autoantibodies and lympho-proliferative response against myelin basic protein (MBP) in leprosy patients (LPs) and th...
journal_title:Microbes and infection
pub_type: 杂志文章
doi:10.1016/j.micinf.2014.12.015
更新日期:2015-04-01 00:00:00
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journal_title:Microbes and infection
pub_type: 杂志文章,评审
doi:10.1016/s1286-4579(02)00005-9
更新日期:2002-11-01 00:00:00
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journal_title:Microbes and infection
pub_type: 杂志文章
doi:10.1016/s1286-4579(01)01470-8
更新日期:2001-11-01 00:00:00
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journal_title:Microbes and infection
pub_type: 杂志文章,评审
doi:10.1016/s1286-4579(03)00071-6
更新日期:2003-05-01 00:00:00
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journal_title:Microbes and infection
pub_type: 杂志文章,评审
doi:10.1016/s1286-4579(02)01603-9
更新日期:2002-07-01 00:00:00
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journal_title:Microbes and infection
pub_type: 杂志文章
doi:10.1016/j.micinf.2017.11.004
更新日期:2018-03-01 00:00:00
abstract::Isolates of Toxoplasma gondii, which is responsible for a wide range of clinical manifestations are grouped into three clonal lineages of different virulence in mice. However, it is not clear whether this genotypic pattern is associated with the clinical profile of the disease in humans nor is the geographical distrib...
journal_title:Microbes and infection
pub_type: 杂志文章
doi:10.1016/j.micinf.2006.03.023
更新日期:2006-08-01 00:00:00
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journal_title:Microbes and infection
pub_type: 杂志文章
doi:10.1016/j.micinf.2011.03.009
更新日期:2011-08-01 00:00:00
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journal_title:Microbes and infection
pub_type: 杂志文章,评审
doi:10.1016/j.micinf.2007.02.006
更新日期:2007-05-01 00:00:00
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journal_title:Microbes and infection
pub_type: 杂志文章
doi:10.1016/j.micinf.2005.11.011
更新日期:2006-04-01 00:00:00
abstract::Several pathogens including Gram-negative bacteria hijack complement regulators to escape host's innate response. Pathogenic Leptospira species bind Factor H, C4b binding protein and vitronectin from the complement system. We evaluated the ability of low passage (LP) and culture-attenuated (CA) pathogenic strains of L...
journal_title:Microbes and infection
pub_type: 杂志文章
doi:10.1016/j.micinf.2019.03.001
更新日期:2019-01-01 00:00:00
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journal_title:Microbes and infection
pub_type: 杂志文章
doi:10.1016/j.micinf.2005.04.011
更新日期:2005-08-01 00:00:00
abstract::The internalization of Aspergillus fumigatus into lung epithelial cells is critical for the infection process in the host. Gliotoxin is the most potent toxin produced by A. fumigatus. However, its role in A. fumigatus internalization into the lung epithelial cells is still largely unknown. In the present study, the de...
journal_title:Microbes and infection
pub_type: 杂志文章
doi:10.1016/j.micinf.2014.03.001
更新日期:2014-06-01 00:00:00
abstract::Paracoccidioides brasiliensis is a dimorphic fungus known to produce invasive systemic disease in humans. The 43-kDa glycoprotein of P. brasiliensis is the major diagnostic antigen of paracoccidioidomycosis and may act as a virulence factor, since it is a receptor for laminin.Very little is known about early interacti...
journal_title:Microbes and infection
pub_type: 杂志文章
doi:10.1016/s1286-4579(00)00390-7
更新日期:2000-07-01 00:00:00
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journal_title:Microbes and infection
pub_type: 杂志文章
doi:10.1016/j.micinf.2011.08.011
更新日期:2012-01-01 00:00:00
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journal_title:Microbes and infection
pub_type: 杂志文章
doi:10.1016/j.micinf.2008.05.007
更新日期:2008-08-01 00:00:00
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journal_title:Microbes and infection
pub_type: 杂志文章,评审
doi:10.1016/j.micinf.2011.04.008
更新日期:2011-09-01 00:00:00
abstract::Leprosy is a chronic infection of the skin and nerves caused by Mycobacterium leprae. Erythema nodosum leprosum (ENL) is a reactive state in lepromatous leprosy. Thalidomide has been used to treat ENL since the 1960s. One of its mechanisms of action is anti-inflammatory through selective inhibition of the pro-inflamma...
journal_title:Microbes and infection
pub_type: 杂志文章,评审
doi:10.1016/s1286-4579(02)01645-3
更新日期:2002-09-01 00:00:00
abstract::The 3'-5'-cyclic guanosine monophosphate (cGMP)-dependent protein kinase (PKG) is the main mediator of cGMP signalling in the malaria parasite. This article reviews the role of PKG in Plasmodium falciparum during gametogenesis and blood stage schizont rupture, as well as the role of the Plasmodium berghei orthologue i...
journal_title:Microbes and infection
pub_type: 杂志文章,评审
doi:10.1016/j.micinf.2012.04.011
更新日期:2012-08-01 00:00:00
abstract::DNA microarray was used as a tool to define the heat- and cold-shock stimulons in Yersinia pestis. Heat shock dramatically enhanced the transcription of genes encoding major heat-shock proteins (MHSPs) that are important for cell survival against the heat. Many other genes were also greatly up-regulated, but their rol...
journal_title:Microbes and infection
pub_type: 杂志文章
doi:10.1016/j.micinf.2004.11.005
更新日期:2005-03-01 00:00:00
abstract::AIDS patients frequently exhibit neurological disorders due to the neurotoxic events that result from HIV-1 and/or opportunistic infections in the brain. This review examines recent clinical findings related to HIV-1-associated dementia, and outlines current areas of basic research that may clarify how HIV-1-associate...
journal_title:Microbes and infection
pub_type: 杂志文章,评审
doi:10.1016/s1286-4579(02)01542-3
更新日期:2002-03-01 00:00:00
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journal_title:Microbes and infection
pub_type: 杂志文章
doi:10.1016/j.micinf.2006.08.013
更新日期:2006-10-01 00:00:00
abstract::Francisella tularensis induces apoptosis within macrophages but the temporal and spatial modulation through activation of caspase-1, caspase-3, and the anti-apoptosis nuclear transcription factor B (NF-kappaB) is not known. Whether escape of the bacteria into the cytosol is sufficient and/or essential for activation o...
journal_title:Microbes and infection
pub_type: 杂志文章
doi:10.1016/j.micinf.2009.11.003
更新日期:2010-02-01 00:00:00
abstract::Fungal allergy including allergic rhinitis, conjunctivitis, bronchial asthma, and allergic bronchopulmonary mycoses results from exposure to spores. In this review we have dealt with the common allergenic fungi and allergens, immunopathogenesis, diagnostic assays, and the possible control of allergy in the future base...
journal_title:Microbes and infection
pub_type: 杂志文章,评审
doi:10.1016/s1286-4579(00)01264-8
更新日期:2000-07-01 00:00:00
abstract::Two-component regulatory systems play an important role in bacterial virulence. We report that mutation of a Pseudomonas aeruginosa gene designated retS (previously designated fimK; accession number PA4856) encoding a putative hybrid two-component regulator, attenuates multiple virulence mechanisms. The retS mutant wa...
journal_title:Microbes and infection
pub_type: 杂志文章
doi:10.1016/j.micinf.2005.04.017
更新日期:2005-10-01 00:00:00
abstract::Clostridium difficile is now established as a major nosocomial pathogen. C. difficile infection is seen almost exclusively as a complication of antibiotic therapy, and is particularly associated with clindamycin and third-generation cephalosporins. Depletion of the indigenous gut microflora by antibiotic therapy has l...
journal_title:Microbes and infection
pub_type: 杂志文章,评审
doi:10.1016/s1286-4579(99)80054-9
更新日期:1999-04-01 00:00:00