Abstract:
:CD4(+)CD25(+) T cells regulate the activity of autoreactive T cells. Depletion of these cells results in the development of a wide-spectrum of organ-specific autoimmune diseases. In vitro model systems have been developed to study the function of these potent suppressor cells. Following their activation via their T-cell receptor, they downregulate the responses of CD25(-) effectors by a T-T interaction.
journal_name
Microbes Infectjournal_title
Microbes and infectionauthors
McHugh RS,Shevach EM,Thornton AMdoi
10.1016/s1286-4579(01)01453-8subject
Has Abstractpub_date
2001-09-01 00:00:00pages
919-27issue
11eissn
1286-4579issn
1769-714Xpii
S1286-4579(01)01453-8journal_volume
3pub_type
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