Gliotoxin from Aspergillus fumigatus affects phagocytosis and the organization of the actin cytoskeleton by distinct signalling pathways in human neutrophils.

abstract：:Host defense requires the maturation and release of the pro-inflammatory cytokines interleukin (IL)-1β and IL-18 and the induction of pyroptotic cell death, which depends on the activation of inflammatory Caspases within inflammasomes by innate immune cells. Several cytosolic pattern recognition receptors (PRRs) have ...

journal_title：Microbes and infection

authors： Radian AD,de Almeida L,Dorfleutner A,Stehlik C

更新日期：2013-07-01 00:00:00

abstract：:While the Vif protein of human immunodeficiency virus type 1 (HIV-1) is essential for viral replication in non-permissive cells, it is rapidly degraded intracellularly. We have previously suggested that the rapid turn-over of Vif is biologically meaningful to prevent detrimental effects of this protein at high express...

journal_title：Microbes and infection

authors： Fujita M,Akari H,Sakurai A,Yoshida A,Chiba T,Tanaka K,Strebel K,Adachi A

更新日期：2004-07-01 00:00:00

abstract：:Research into intracellular sensing of microbial products is an up and coming field in innate immunity. Nod1 and Nod2 are members of the rapidly expanding family of NACHT domain-containing proteins involved in intracellular recognition of bacterial products. Nods proteins are involved in the cytosolic detection of pep...

journal_title：Microbes and infection

authors： Bourhis LL,Werts C

更新日期：2007-04-01 00:00:00

abstract：:Francisella tularensis subspecies (subsp.) tularensis is a CDC Category A biological warfare agent and inhalation of as few as 15 bacilli can initiate severe disease. Relatively little is known about the cellular and molecular mechanisms of host defense against respiratory infection with subsp. tularensis. In this stu...

journal_title：Microbes and infection

authors： KuoLee R,Harris G,Conlan JW,Chen W

更新日期：2011-05-01 00:00:00

abstract：:Recent studies have shown that infection with Porphyromonas gingivalis, a major periodontal pathogen, hastens the progression of non-alcoholic fatty liver disease (NAFLD). However, the intracellular fate of P. gingivalis in hepatocytes remains unknown. Here, using oleic-acid-induced HepG2 cells as an in vitro model fo...

journal_title：Microbes and infection

authors： Zaitsu Y,Iwatake M,Sato K,Tsukuba T

更新日期：2016-09-01 00:00:00

abstract：:The iron-limitation-inducible protein FrpB of Neisseria meningitidis is an outer-membrane-localized siderophore receptor. Because of its abundance and its capacity to elicit bactericidal antibodies, it is considered a vaccine candidate. Bactericidal antibodies against FrpB are, however, type-specific. Hence, an FrpB-b...

journal_title：Microbes and infection

authors： Kortekaas J,Müller SA,Ringler P,Gregorini M,Weynants VE,Rutten L,Bos MP,Tommassen J

更新日期：2006-07-01 00:00:00

abstract：:Infection of mice with Plasmodium berghei NK65 represents a well-recognized malaria model in which infection is accompanied by an intense hepatic inflammatory response. Enzyme-inducible nitric oxide synthase is an important regulator of inflammation and leukocyte recruitment in microvessels, but these functions have y...

journal_title：Microbes and infection

authors： Oliveira-Lima OC,Bernardes D,Xavier Pinto MC,Esteves Arantes RM,Carvalho-Tavares J

更新日期：2013-11-01 00:00:00

abstract：:Lactobacilli are normal inhabitants of our microbiota and are known to protect against pathogens. Neisseria gonorrhoeae is a human specific pathogenic bacterium that colonises the urogenital tract where it causes gonorrhoea. In this study we analysed early interactions between lactobacilli and gonococci and investigat...

journal_title：Microbes and infection

authors： Vielfort K,Sjölinder H,Roos S,Jonsson H,Aro H

更新日期：2008-10-01 00:00:00

abstract：:Although Pneumocystis carinii pneumonia is one of the leading causes of morbidity and mortality among patients with the acquired immunodeficiency syndrome, many questions about its epidemiology and transmission remain unanswered. Whereas traditional theory postulates that the disease results from reactivation of laten...

journal_title：Microbes and infection

authors： Morris A,Beard CB,Huang L

更新日期：2002-01-01 00:00:00

abstract：:Yersiniabactin (Ybt) is a siderophore-dependent iron uptake system encoded on a pathogenicity island that is widespread among pathogenic bacteria including the Yersiniae. While biosynthesis of the siderophore has been elucidated, the secretion mechanism and a few components of the uptake/utilization pathway are uniden...

journal_title：Microbes and infection

authors： Perry RD,Fetherston JD

更新日期：2011-09-01 00:00:00

abstract：:DNA microarray was used as a tool to define the heat- and cold-shock stimulons in Yersinia pestis. Heat shock dramatically enhanced the transcription of genes encoding major heat-shock proteins (MHSPs) that are important for cell survival against the heat. Many other genes were also greatly up-regulated, but their rol...

journal_title：Microbes and infection

authors： Han Y,Zhou D,Pang X,Zhang L,Song Y,Tong Z,Bao J,Dai E,Wang J,Guo Z,Zhai J,Du Z,Wang X,Wang J,Huang P,Yang R

更新日期：2005-03-01 00:00:00

abstract：:Lactobacillus colonisation was examined in 112 Swedish infants. Faecal samples obtained at 1, 2, 4 and 8 weeks and at 6, 12 and 18 months of age were cultivated quantitatively on Rogosa agar. Lactobacilli were speciated by PCR and typed to the strain level by randomly amplified polymorphic DNA (RAPD). Lactobacilli rea...

journal_title：Microbes and infection

authors： Ahrné S,Lönnermark E,Wold AE,Aberg N,Hesselmar B,Saalman R,Strannegård IL,Molin G,Adlerberth I

更新日期：2005-08-01 00:00:00

abstract：:Helicobacter hepaticus strain 3B1 (H. hepaticus) contains a genomic island of approximately 71 kb, HHGI1, with some of the common features shared among known bacterial pathogenicity islands. In this study, we characterized the pathogenic potential of HHGI1 by infecting B6.129-IL10 tm1Cgn (IL10-/-) mice with an isogeni...

journal_title：Microbes and infection

authors： Ge Z,Sterzenbach T,Whary MT,Rickman BH,Rogers AB,Shen Z,Taylor NS,Schauer DB,Josenhans C,Suerbaum S,Fox JG

更新日期：2008-06-01 00:00:00

abstract：:Control of human African trypanosomiasis (HAT) is highly dependent on the ability to detect and treat infected individuals. However, a number of individuals exposed to Trypanosoma brucei gambiense are able to control infection to undetectable levels in blood. They are long-term potential reservoirs and thus a threat f...

journal_title：Microbes and infection

authors： Ilboudo H,Jamonneau V,Koffi M,Kaboré J,Amoussa R,Holzmuller P,Garcia A,Bucheton B,Courtin D

更新日期：2016-06-01 00:00:00

abstract：:Burkholderia pseudomallei is a major cause of bacterial septicemias in many parts of the world, particularly Thailand; the known geographic range of the organism appears to be enlarging as awareness of the organism and the disease it causes--melioidosis--increases. B. pseudomallei is intrinsically resistant to most an...

journal_title：Microbes and infection

authors： Woods DE,DeShazer D,Moore RA,Brett PJ,Burtnick MN,Reckseidler SL,Senkiw MD

更新日期：1999-02-01 00:00:00

abstract：:We have previously reported that mice immunized with the mycobacterial 27-kDa lipoprotein were more susceptible to Mycobacterium tuberculosis (Mtb) challenge. We also showed that 27-kDa lipoprotein abrogated the protection afforded by the BCG vaccine when administrated together, suggesting that the 27-kDa lipoprotein ...

journal_title：Microbes and infection

authors： Hovav AH,Mullerad J,Maly A,Davidovitch L,Fishman Y,Bercovier H

更新日期：2006-06-01 00:00:00

abstract：:Enterotoxigenic Escherichia coli (ETEC) are a major cause of diarrheal illness in developing countries, and perennially the most common cause of traveller's diarrhea. ETEC constitute a diverse pathotype that elaborate heat-labile and/or heat-stable enterotoxins. Recent molecular pathogenesis studies reveal sophisticat...

journal_title：Microbes and infection

authors： Fleckenstein JM,Hardwidge PR,Munson GP,Rasko DA,Sommerfelt H,Steinsland H

更新日期：2010-02-01 00:00:00

abstract：:The invasin protein encoded by enteropathogenic Yersinia allows entry of bacteria into intestinal M cells by binding to integrin receptors. In cultured cells, invasin-mediated uptake requires proteins involved in endocytosis and signaling to the cell cytoskeleton. At least four different factors have been demonstrated...

journal_title：Microbes and infection

authors： Isberg RR,Hamburger Z,Dersch P

更新日期：2000-06-01 00:00:00

abstract：:Numerous Chlamydia trachomatis proteins have been identified as potential subunit vaccines, of which the major outer-membrane protein (MOMP) has, so far, proven the most efficacious. Recently, subunit A of the V-type ATP synthase (ATPase; TC0582) complex was shown to elicit partial protection against infection. Comput...

journal_title：Microbes and infection

authors： Tifrea DF,Barta ML,Pal S,Hefty PS,de la Maza LM

更新日期：2016-04-01 00:00:00

abstract：:We analyzed the distribution and expression of cadherin and beta-catenin during Trypanosoma cruzi-cardiomyocyte interaction. Confocal microscopy revealed cadherin associated with beta-catenin at the cell-cell contacts. After 24h of infection, the spatial distribution and expression of both adherens junction (AJ) prote...

journal_title：Microbes and infection

authors： de Melo TG,Meirelles Mde N,Pereira MC

更新日期：2008-10-01 00:00:00

abstract：:Erysipelothrix rhusiopathiae is the causative agent of erysipelas in animals and erysipeloid in humans. In the absence of specific antibodies, the organism evades phagocytosis by phagocytic cells, but even if phagocytized, it is able to replicate intracellulary in these cells. In this review, recent advances in our un...

journal_title：Microbes and infection

authors： Shimoji Y

更新日期：2000-07-01 00:00:00

abstract：:Drug-resistant tuberculosis (TB), including the more severe forms of multidrug- and extensively drug-resistant forms, is an increasing public health concern globally. In Sweden the majority of patients with TB are immigrants from countries with a high incidence of TB including the drug-resistant forms. In this study, ...

journal_title：Microbes and infection

authors： Ghebremichael S,Petersson R,Koivula T,Pennhag A,Romanus V,Berggren I,Petrini B,Hoffner S,Källenius G

更新日期：2008-05-01 00:00:00

abstract：:A robust and reliable cell culture system for serum-derived HCV (HCVser) has not been established yet because of the presence of neutralizing antibody and tropism for infection. To overcome this obstacle, we employed a lipid-mediated protein intracellular delivery reagent (PIDR) that permits internalization of protein...

journal_title：Microbes and infection

authors： Fukuhara T,Tani H,Shiokawa M,Goto Y,Abe T,Taketomi A,Shirabe K,Maehara Y,Matsuura Y

更新日期：2011-04-01 00:00:00

abstract：:The internalization of Aspergillus fumigatus into lung epithelial cells is critical for the infection process in the host. Gliotoxin is the most potent toxin produced by A. fumigatus. However, its role in A. fumigatus internalization into the lung epithelial cells is still largely unknown. In the present study, the de...

journal_title：Microbes and infection

authors： Jia X,Chen F,Pan W,Yu R,Tian S,Han G,Fang H,Wang S,Zhao J,Li X,Zheng D,Tao S,Liao W,Han X,Han L

更新日期：2014-06-01 00:00:00

abstract：:Immune-mediated clearance of virus from the central nervous system (CNS) differs from that of the other organs. Mechanisms of virus control are largely dependent upon the target cell type. Although cytolytic T lymphocytes may mediate clearance of virus from glial cells, non-cytolytic mechanisms mediated by antibody an...

journal_title：Microbes and infection

authors： Binder GK,Griffin DE

更新日期：2003-04-01 00:00:00

abstract：:CCR5-tropic (R5) immunodeficiency virus type 1 (HIV-1) strains are highly transmissible during the early stage of infection in humans, whereas CXCR4-tropic (X4) strains are less transmissible. This study aimed to explore the basis for early phase R5 and X4 HIV-1 infection in vivo by using humanized mice dually challen...

journal_title：Microbes and infection

authors： Terahara K,Ishige M,Ikeno S,Okada S,Kobayashi-Ishihara M,Ato M,Tsunetsugu-Yokota Y

更新日期：2015-05-01 00:00:00

abstract：:Previously, we demonstrated that Valpha14+ NKT cells and IFN-gamma are important upstream components in neutrophil-mediated host defense against infection with Streptococcus pneumoniae. In the present study, we extended these findings by elucidating the role of IFN-gamma in this Valpha14+ NKT cell-promoted process. Ad...

journal_title：Microbes and infection

authors： Nakamatsu M,Yamamoto N,Hatta M,Nakasone C,Kinjo T,Miyagi K,Uezu K,Nakamura K,Nakayama T,Taniguchi M,Iwakura Y,Kaku M,Fujita J,Kawakami K

更新日期：2007-03-01 00:00:00

abstract：:Denaturing high-performance liquid chromatography (DHPLC) is a relatively new technique, which utilizes heteroduplex formation between wild-type and mutated DNA strands to identify point mutations. Heteroduplex molecules are separated from homoduplex molecules by ion-pair, reverse-phase liquid chromatography on a spec...

journal_title：Microbes and infection

authors： Shi R,Otomo K,Yamada H,Tatsumi T,Sugawara I

更新日期：2006-01-01 00:00:00

abstract：:In experimental Trypanosoma cruzi infections, severe thymic atrophy leads to release of activated CD4(+)CD8(+) double-positive (DP) T cells to the periphery. In humans, activated DP T cells are found in the blood in association with severe cardiac forms of human chronic Chagas disease. The mechanisms underlying the pr...

journal_title：Microbes and infection

authors： Nardy AF,Luiz da Silva Filho J,Pérez AR,de Meis J,Farias-de-Oliveira DA,Penha L,de Araújo Oliveira I,Dias WB,Todeschini AR,Freire-de-Lima CG,Bellio M,Caruso-Neves C,Pinheiro AA,Takiya CM,Bottasso O,Savino W,Morrot A

更新日期：2013-05-01 00:00:00

abstract：:Kinins, the vasoactive peptides proteolytically liberated from kininogens, were recently recognized as signals alerting the innate immune system. Here we demonstrate that Leishmania donovani and Leishmania chagasi, two etiological agents of visceral leishmaniasis (VL), activate the kinin system. Intravital microscopy ...

journal_title：Microbes and infection

authors： Svensjö E,Batista PR,Brodskyn CI,Silva R,Lima AP,Schmitz V,Saraiva E,Pesquero JB,Mori MA,Müller-Esterl W,Scharfstein J

更新日期：2006-01-01 00:00:00