Abstract：
:Control of human African trypanosomiasis (HAT) is highly dependent on the ability to detect and treat infected individuals. However, a number of individuals exposed to Trypanosoma brucei gambiense are able to control infection to undetectable levels in blood. They are long-term potential reservoirs and thus a threat for control strategies. Cytokine responses in whole blood stimulation assays were quantified in individuals with contrasting HAT status. Trypanosome-induced IFN-γ production was only observed in "trypanotolerant" subjects suspected of harboring latent infections. This result contributes new insights into the immune responses associated with infection control and opens novel diagnosis perspectives regarding HAT elimination.
journal_name
Microbes Infectjournal_title
Microbes and infectionauthors
Ilboudo H,Jamonneau V,Koffi M,Kaboré J,Amoussa R,Holzmuller P,Garcia A,Bucheton B,Courtin Ddoi
10.1016/j.micinf.2016.03.002subject
Has Abstractpub_date
2016-06-01 00:00:00pages
436-440issue
6eissn
1286-4579issn
1769-714Xpii
S1286-4579(16)00048-4journal_volume
18pub_type
杂志文章abstract：:Trypanosoma cruzi the cause of Chagas disease persists in tissues of infected experimental animals and humans. Here we demonstrate the persistence of the parasite in adipose tissue from of three of 10 elderly seropositive patients with chronic chagasic heart disease. Nine control patients had no parasites in the fat. ...
journal_title：Microbes and infection
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journal_title：Microbes and infection
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journal_title：Microbes and infection
pub_type： 杂志文章,评审
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journal_title：Microbes and infection
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journal_title：Microbes and infection
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journal_title：Microbes and infection
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journal_title：Microbes and infection
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pub_type： 杂志文章,评审
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journal_title：Microbes and infection
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更新日期：2019-01-01 00:00:00
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journal_title：Microbes and infection
pub_type： 杂志文章
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更新日期：2006-08-01 00:00:00
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journal_title：Microbes and infection
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journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2004.11.007
更新日期：2005-03-01 00:00:00
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journal_title：Microbes and infection
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journal_title：Microbes and infection
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journal_title：Microbes and infection
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journal_title：Microbes and infection
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journal_title：Microbes and infection
pub_type： 杂志文章,评审
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更新日期：2002-12-01 00:00:00
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journal_title：Microbes and infection
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journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2006.04.004
更新日期：2006-07-01 00:00:00
abstract：:The internalization of Aspergillus fumigatus into lung epithelial cells is critical for the infection process in the host. Gliotoxin is the most potent toxin produced by A. fumigatus. However, its role in A. fumigatus internalization into the lung epithelial cells is still largely unknown. In the present study, the de...
journal_title：Microbes and infection
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更新日期：2014-06-01 00:00:00
