Abstract：
:In contrast to most gammaherpesviruses, Bovine herpesvirus 4 (BoHV-4) has a broad range of host species both in vitro and in vivo. Several in vitro studies demonstrated that some human cell lines are sensitive or even permissive to BoHV-4. These observations led to the hypothesis that cross-species transmission of BoHV-4 could lead to human infections. In the present study, we investigate the sensitivity of BoHV-4 to neutralization by naïve human sera in order to determine if humans exhibit innate anti-viral activities against this virus. Our results demonstrate that human sera from naïve individuals, in contrast to the sera of naïve subjects from various animal species, neutralize BoHV-4 efficiently. A series of complementary experiments were performed to unravel the mechanism(s) of this neutralization. The data obtained in this study demonstrates that human serum neutralizes BoHV-4 in a complement dependent manner activated by natural antibodies raised against the Galalpha1-3Galbeta1-4GlcNAc-R epitope expressed by bovine cells.
journal_name
Microbes Infectjournal_title
Microbes and infectionauthors
Machiels B,Gillet L,Nascimento Brito SD,Drion P,Delforge C,Nizet Y,Gianello P,Bona C,Costes B,Markine-Goriaynoff N,Vanderplasschen Adoi
10.1016/j.micinf.2007.08.007subject
Has Abstractpub_date
2007-11-01 00:00:00pages
1530-7issue
14-15eissn
1286-4579issn
1769-714Xpii
S1286-4579(07)00276-6journal_volume
9pub_type
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