Abstract：
:Zika virus (ZIKV) greatly impacted the international scientific and public health communities in the last two years due to its association with microcephaly and other neonatal alterations. This review will discuss lessons learned from viral pathogenesis, epidemiology and clinical findings observed during the ZIKV outbreak occurred between 2014 and 2016 in Brazil.
journal_name
Microbes Infectjournal_title
Microbes and infectionauthors
Proenca-Modena JL,Milanez GP,Costa ML,Judice CC,Maranhão Costa FTdoi
10.1016/j.micinf.2018.02.008subject
Has Abstractpub_date
2018-12-01 00:00:00pages
661-669issue
11-12eissn
1286-4579issn
1769-714Xpii
S1286-4579(18)30052-2journal_volume
20pub_type
杂志文章,评审abstract：:This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. ...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2008.04.003
更新日期：2008-04-16 00:00:00
abstract：:The establishment of infection by Brucella ovis and Brucella canis in J774.A1 macrophages was found to be dependent upon cholesterol and ganglioside GM(1), two components of lipid rafts. This process also required a class A scavenger receptor of macrophages, and was not inhibited by smooth and rough lipopolysaccharide...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2009.12.008
更新日期：2010-03-01 00:00:00
abstract：:Pneumococcal serine-rich repeat protein (PsrP) is a glycoprotein that mediates Streptococcus pneumoniae attachment to lung cells and promotes biofilm formation. Herein, we investigated the transcriptional organization of psrP-secY2A2, the 37-kbp pathogenicity island encoding PsrP and its accessory genes. PCR amplifica...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2017.04.001
更新日期：2017-06-01 00:00:00
abstract：:Sheep develop clinical diseases after 3-5 years after infection with Mycobacterium avium subsp. paratuberculosis (MAP). Clinical symptoms of paratuberculosis include persistent diarrhea and weight loss due to a chronic inflammation of the small intestine. Tissue alterations in the areas of the ileo-cecal junction are ...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2009.04.006
更新日期：2009-05-01 00:00:00
abstract：:In schistosomiasis, the current control strategy does not prevent reinfection, therefore, vaccine strategies are essential to combat the Schistosoma mansoni. The efficacy vaccine depends on parasite stage and effective adjuvant. We have recently demonstrated that S. mansoni schistosomula tegument (Smteg) is able to ac...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2012.10.007
更新日期：2013-01-01 00:00:00
abstract：:We previously found that, in a mouse model of Chagas cardiomyopathy, 18% of the 9390 quantified unigenes were significantly regulated by Trypanosoma cruzi infection. However, treatment with bone marrow-derived mononuclear cells (MNCs) resulted in 84% transcriptomic recovery. We have applied new algorithms to reanalyze...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2017.11.003
更新日期：2018-03-01 00:00:00
abstract：:Novel coronavirus disease 2019 (COVID-19) pandemic is the most recent health care crisis without specific prophylactic or therapeutic drugs. Antimalarial drug chloroquine (CHL) and its safer derivative hydroxychloroquine (HCHL) have been proposed to be repurposed to treat SARS coronavirus-2 (SARS-CoV-2), the causative...
journal_title：Microbes and infection
pub_type： 信件
doi：10.1016/j.micinf.2020.04.004
更新日期：2020-01-01 00:00:00
abstract：:Motility is essential for Helicobacter pylori colonization. This review discusses the biochemistry, genetics and genomics of the H. pylori flagellum, and compares these features with well-characterized bacteria. ...
journal_title：Microbes and infection
pub_type： 杂志文章,评审
doi：10.1016/s1286-4579(00)01274-0
更新日期：2000-08-01 00:00:00
abstract：:Anti-retroviral therapy is useful to treat human immunodeficiency virus type 1 (HIV-1)-infected individuals, but has some major problems, such as the generation of multidrug-resistant viruses. To develop a novel supplemental or alternative therapeutic for CCR5-tropic (R5) HIV-1 infection, we generated a recombinant ve...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2016.12.004
更新日期：2017-01-01 00:00:00
abstract：:Isolates of Toxoplasma gondii, which is responsible for a wide range of clinical manifestations are grouped into three clonal lineages of different virulence in mice. However, it is not clear whether this genotypic pattern is associated with the clinical profile of the disease in humans nor is the geographical distrib...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2006.03.023
更新日期：2006-08-01 00:00:00
abstract：:Mathematical models of the dynamics of HIV and hepatitis C virus infection have proven to be of great utility in understanding pathogenesis and designing better treatments. Here, we review the state of the art in modeling and interpreting data obtained from hepatitis B virus infected patients treated with antiviral ag...
journal_title：Microbes and infection
pub_type： 杂志文章,评审
doi：10.1016/s1286-4579(02)01603-9
更新日期：2002-07-01 00:00:00
abstract：:Salmonella, a Gram-negative facultative intracellular pathogen is capable of infecting vast array of hosts. The striking ability of Salmonella to overcome every hurdle encountered in the host proves that they are true survivors. In the host, Salmonella infects various cell types and needs to survive and replicate by c...
journal_title：Microbes and infection
pub_type： 杂志文章,评审
doi：10.1016/j.micinf.2010.05.010
更新日期：2010-10-01 00:00:00
abstract：:Erysipelothrix rhusiopathiae is the causative agent of erysipelas in animals and erysipeloid in humans. In the absence of specific antibodies, the organism evades phagocytosis by phagocytic cells, but even if phagocytized, it is able to replicate intracellulary in these cells. In this review, recent advances in our un...
journal_title：Microbes and infection
pub_type： 杂志文章,评审
doi：10.1016/s1286-4579(00)00397-x
更新日期：2000-07-01 00:00:00
abstract：:This short review will highlight three areas of current research on the role of complement in bacterial infection. These are i) the use of mice with targeted disruption of complement genes to study infectious disease models; ii) studies on the interactions between bacterial virulence factors and complement regulatory ...
journal_title：Microbes and infection
pub_type： 杂志文章,评审
doi：10.1016/s1286-4579(99)80063-x
更新日期：1999-07-01 00:00:00
abstract：:This review elaborates on recent insights gained on the dynamic aspects of interactions between pathogen and the host intracellular machinery in tuberculosis infection. In addition we will also discuss the utility of adopting a systems biology approach, both for a better understanding of TB biology, and for the develo...
journal_title：Microbes and infection
pub_type： 杂志文章,评审
doi：10.1016/j.micinf.2010.10.009
更新日期：2011-02-01 00:00:00
abstract：:The intestine is inhabited by a diverse range of microorganisms, which requires the host to employ numerous barrier measures to prevent bacterial invasion. However, the intestinal microbiota additionally acts symbiotically with host cells to maintain epithelial barrier function, and perturbation to this interaction pl...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2020.10.009
更新日期：2020-11-12 00:00:00
abstract：:The Mycobacterium abscessus complex can cause fatal pulmonary disease, especially in cystic fibrosis patients. Diagnosing M. abscessus complex pulmonary disease is challenging. Immunologic assays specific for M. abscessus are not available. In this study seven clinical M. abscessus complex strains and the M. abscessus...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2018.10.006
更新日期：2019-01-01 00:00:00
abstract：:Leprosy is a chronic infection of the skin and nerves caused by Mycobacterium leprae. Erythema nodosum leprosum (ENL) is a reactive state in lepromatous leprosy. Thalidomide has been used to treat ENL since the 1960s. One of its mechanisms of action is anti-inflammatory through selective inhibition of the pro-inflamma...
journal_title：Microbes and infection
pub_type： 杂志文章,评审
doi：10.1016/s1286-4579(02)01645-3
更新日期：2002-09-01 00:00:00
abstract：:Most pandemic influenza virus strains undergo adaptation or reassortment before they acquire the ability to cause fatal infections in a new host species. The pathologic changes and tissue tropism during virus adaptation are not fully understood. Here we investigated pathologic changes and tissue tropism by serial lung...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2008.09.013
更新日期：2009-01-01 00:00:00
abstract：:The identification of Brachyspira hyodysenteriae outer membrane proteins (OMPs) that may stimulate immunity to swine dysentery is important for vaccine development. We report here the analysis of a novel locus, blpGFEA, encoding four tandem paralogous proteins of approximately 30 kDa from B. hyodysenteriae. The four p...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/s1286-4579(03)00027-3
更新日期：2003-04-01 00:00:00
abstract：:Interleukin (IL)-15 is a recently described cytokine that resembles IL-2 in its biological activities, stimulating natural killer cells, T cells and B cells to proliferate, secrete cytokines, and exhibit increased cytotoxicities or produce antibody. IL-15 also exerts unique functions such as stimulation of phagocytes,...
journal_title：Microbes and infection
pub_type： 杂志文章,评审
doi：10.1016/s1286-4579(00)00329-4
更新日期：2000-04-01 00:00:00
abstract：:Protective immunity against cutaneous leishmaniasis is dependent on the induction of Th1/Tc1 immune responses resulting in efficient parasite elimination. In this review, the mechanisms leading to protection are discussed with special focus on the role of Leishmania major-infected dendritic cells (DC) in induction of ...
journal_title：Microbes and infection
pub_type： 杂志文章,评审
doi：10.1016/j.micinf.2004.05.024
更新日期：2004-10-01 00:00:00
abstract：:Lactobacilli are normal inhabitants of our microbiota and are known to protect against pathogens. Neisseria gonorrhoeae is a human specific pathogenic bacterium that colonises the urogenital tract where it causes gonorrhoea. In this study we analysed early interactions between lactobacilli and gonococci and investigat...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2008.07.032
更新日期：2008-10-01 00:00:00
abstract：:The PE and PPE family of proteins of Mycobacterium tuberculosis have been hypothesized to play important roles in the biology of the organism and some proteins have been shown to be involved in eliciting T-cell responses. Earlier, we had identified putative HLA class I binding epitopes of the PE and PPE proteins of My...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2008.04.017
更新日期：2008-07-01 00:00:00
abstract：:A robust and reliable cell culture system for serum-derived HCV (HCVser) has not been established yet because of the presence of neutralizing antibody and tropism for infection. To overcome this obstacle, we employed a lipid-mediated protein intracellular delivery reagent (PIDR) that permits internalization of protein...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2011.01.005
更新日期：2011-04-01 00:00:00
abstract：:Mucosal epithelial cells express an autonomous innate immune response that controls the overgrowth of invaded bacteria, mitigates the harmful effects of the bacteria carried within, and does not rely on other external arms of the immune response. Epithelial cell autonomous innate immunity "respects" the social biology...
journal_title：Microbes and infection
pub_type： 杂志文章,评审
doi：10.1016/j.micinf.2016.03.008
更新日期：2016-06-01 00:00:00
abstract：:Paracoccidioides brasiliensis is a dimorphic fungus known to produce invasive systemic disease in humans. The 43-kDa glycoprotein of P. brasiliensis is the major diagnostic antigen of paracoccidioidomycosis and may act as a virulence factor, since it is a receptor for laminin.Very little is known about early interacti...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/s1286-4579(00)00390-7
更新日期：2000-07-01 00:00:00
abstract：:Absent in melanoma 2 (AIM2) is a sensor of cytosolic dsDNA and is responsible for the activation of inflammatory and host immune responses to DNA viruses and intracellular bacteria. AIM2 is a member of the hematopoietic interferon-inducible nuclear proteins with a 200 amino-acid repeat (HIN200) family, containing a py...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2018.09.001
更新日期：2019-03-01 00:00:00
abstract：:The occurrence of Bacillus thuringiensis bacteremia in a neutropenic patient suffering from severe pulmonary disease addressed the question of whether the aggressive behavior of B. thuringiensis depended on the host status and/or on the membrane-damaging toxins the isolate produced. After intratracheal injection, BALB...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2007.02.001
更新日期：2007-04-01 00:00:00
abstract：:Clostridium difficile is now established as a major nosocomial pathogen. C. difficile infection is seen almost exclusively as a complication of antibiotic therapy, and is particularly associated with clindamycin and third-generation cephalosporins. Depletion of the indigenous gut microflora by antibiotic therapy has l...
journal_title：Microbes and infection
pub_type： 杂志文章,评审
doi：10.1016/s1286-4579(99)80054-9
更新日期：1999-04-01 00:00:00
