Abstract：
:Comparative genomics and microarrays reveal that the genomes of different Salmonella enterica serovars are distinguished from each other by the presence or absence of hundreds of genes. The distribution of these variable genome regions is often not clonal. Therefore, lateral gene transfer (LGT) plays an important role in diversity among Salmonella. Overall, almost one quarter of the entire S. enterica sv Typhimurium genome may have been introduced by LGT.
journal_name
Microbes Infectjournal_title
Microbes and infectionauthors
Porwollik S,McClelland Mdoi
10.1016/s1286-4579(03)00186-2subject
Has Abstractpub_date
2003-09-01 00:00:00pages
977-89issue
11eissn
1286-4579issn
1769-714Xpii
S1286457903001862journal_volume
5pub_type
杂志文章,评审abstract：:A non-toxigenic tox gene-bearing (NTTB) Corynebacterium ulcerans was grown from the wound of a 61-year-old gardener and in a nasal specimen from the patient's asymptomatic dog. The two isolates were similar in terms of antibiogram, multilocus sequence typing (ST341), virulence genes, and only three SNPs were found to ...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2015.07.004
更新日期：2015-10-01 00:00:00
abstract：:This study analyzed macrophage inflammatory protein-2 (MIP-2) production and neutrophil recruitment in urinary tract in response to Pseudomonas aeruginosa in an ascending model of urinary tract infection (UTI) in mice. Both planktonic and biofilm cells of P. aeruginosa were used for inducing UTI in mice. MIP-2 levels ...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2004.08.008
更新日期：2004-11-01 00:00:00
abstract：:The objective of this study was to determine if inflammatory tolerance and enhancement of innate immune function could be induced by the Gram-positive cell wall component peptidoglycan (PGN). Male mice (C57BL6/J or C3H/HeJ, 8-12 weeks of age) were given intraperitoneal injections of 1mg PGN on 2 consecutive days. The ...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2008.07.021
更新日期：2008-10-01 00:00:00
abstract：:In this study, the effect of Yersinia derivatives on nitric oxide (NO), hydrogen peroxide (H2O2) and tumor necrosis factor-alpha (TNF-alpha) production by murine peritoneal macrophages was investigated. Addition of lipopolysaccharide (LPS) to the macrophage culture resulted in NO production that was dose dependent. On...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2003.10.012
更新日期：2004-02-01 00:00:00
abstract：:E protein is a membrane component of severe acute respiratory syndrome coronavirus (SARS-CoV). Disruption of E protein may reduce viral infectivity. Thus, the SARS-CoV E protein is considered a potential target for the development of antiviral drugs. However, the cellular immune responses to E protein remain unclear i...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2006.05.008
更新日期：2006-08-01 00:00:00
abstract：:Pathogenic Leptospira species are the causative agents of leptospirosis, a global zoonotic infectious disease. Toxin-antitoxin (TA) modules have been confirmed as stress-response elements that induce prokaryotic and eukaryotic cell-growth arrest or death, but their role in the virulence of Leptospira has not been repo...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2014.10.010
更新日期：2015-01-01 00:00:00
abstract：:Absent in melanoma 2 (AIM2) is a sensor of cytosolic dsDNA and is responsible for the activation of inflammatory and host immune responses to DNA viruses and intracellular bacteria. AIM2 is a member of the hematopoietic interferon-inducible nuclear proteins with a 200 amino-acid repeat (HIN200) family, containing a py...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2018.09.001
更新日期：2019-03-01 00:00:00
abstract：:Effective vaccines against infectious diseases and biological warfare agents remain an urgent public health priority. Studies have characterized the differentiation of effector and memory T cells and identified a subset of T cells capable of conferring enhanced protective immunity against pathogen challenge. We hypoth...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2007.07.009
更新日期：2007-10-01 00:00:00
abstract：:Amoebiasis is responsible for 50000-100000 deaths annually. Invasive amoebic disease begins with the attachment of Entamoeba histolytica trophozoites to colonic mucin, a process mediated by the amoebic Gal/GalNAc lectin. The non-pathogenic counterpart, E. dispar, is morphologically identical but genetically distinct. ...
journal_title：Microbes and infection
pub_type： 杂志文章,评审
doi：10.1016/s1286-4579(00)01330-7
更新日期：2000-11-01 00:00:00
abstract：:Very recently, a new avian flu outbreak in humans, which is caused by a novel H7N9 influenza A virus (AIV), was reported in China. As of April 13, 2013, 49 confirmed cases (mainly middle-aged to elderly males), including 11 deaths, were reported in China. Here we analyzed the genomic signatures and protein sequences o...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2013.04.004
更新日期：2013-06-01 00:00:00
abstract：:Enterotoxigenic Escherichia coli (ETEC) are a major cause of diarrheal illness in developing countries, and perennially the most common cause of traveller's diarrhea. ETEC constitute a diverse pathotype that elaborate heat-labile and/or heat-stable enterotoxins. Recent molecular pathogenesis studies reveal sophisticat...
journal_title：Microbes and infection
pub_type： 杂志文章,评审
doi：10.1016/j.micinf.2009.10.002
更新日期：2010-02-01 00:00:00
abstract：:Cell-mediated immunity, leading to Mycobacterium tuberculosis (Mtb)-constraining granuloma formation, is the major component of host defense against tuberculosis and is regulated by the balance of cytokines secreted mostly by mononuclear phagocytes and lymphocytes. To better understand the role of monocytes in the reg...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2003.10.007
更新日期：2004-01-01 00:00:00
abstract：:The PE and PPE family of proteins of Mycobacterium tuberculosis have been hypothesized to play important roles in the biology of the organism and some proteins have been shown to be involved in eliciting T-cell responses. Earlier, we had identified putative HLA class I binding epitopes of the PE and PPE proteins of My...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2008.04.017
更新日期：2008-07-01 00:00:00
abstract：:Staphylococcus aureus is a major cause of hospital-acquired infections. The ability to survive on abiotic surfaces is an important characteristic that facilitates transmission between human hosts. We found that S. aureus survivors of dry surface incubation are resistant to subsequent dry stress exposure. Survivors als...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2015.02.004
更新日期：2015-06-01 00:00:00
abstract：:Previously, we demonstrated that Valpha14+ NKT cells and IFN-gamma are important upstream components in neutrophil-mediated host defense against infection with Streptococcus pneumoniae. In the present study, we extended these findings by elucidating the role of IFN-gamma in this Valpha14+ NKT cell-promoted process. Ad...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2006.12.003
更新日期：2007-03-01 00:00:00
abstract：:Paracoccidioides brasiliensis is a dimorphic fungus known to produce invasive systemic disease in humans. The 43-kDa glycoprotein of P. brasiliensis is the major diagnostic antigen of paracoccidioidomycosis and may act as a virulence factor, since it is a receptor for laminin.Very little is known about early interacti...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/s1286-4579(00)00390-7
更新日期：2000-07-01 00:00:00
abstract：:To increase knowledge of the pathogenic potential of the Burkholderia cepacia complex (BCC), we investigated the effects of reference strains of the nine BCC species on human bronchial epithelial cells in vitro. B. multivorans exhibited the highest rates of adherence to and internalization by host cells. Two out of th...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2007.10.002
更新日期：2008-01-01 00:00:00
abstract：:Malaria is an infectious disease caused by parasites of the genus Plasmodium. This intraerythrocytic protozoan produces hemozoin (HZ), an insoluble crystalline metabolite resulting from the heme detoxification mechanism. This review will focus on HZ biosynthesis and synthetic preparation, but in particular on its effe...
journal_title：Microbes and infection
pub_type： 杂志文章,评审
doi：10.1016/j.micinf.2010.07.001
更新日期：2010-11-01 00:00:00
abstract：:This short review will highlight three areas of current research on the role of complement in bacterial infection. These are i) the use of mice with targeted disruption of complement genes to study infectious disease models; ii) studies on the interactions between bacterial virulence factors and complement regulatory ...
journal_title：Microbes and infection
pub_type： 杂志文章,评审
doi：10.1016/s1286-4579(99)80063-x
更新日期：1999-07-01 00:00:00
abstract：:Despite the development of new treatments, the mortality due to invasive pulmonary aspergillosis remains above 50%, reaching 95% in certain situations. The battle against Aspergillus fumigatus involves several components of the pulmonary innate immune system: cells, mediators, and natural antifungal molecules involved...
journal_title：Microbes and infection
pub_type： 杂志文章,评审
doi：10.1016/j.micinf.2009.07.002
更新日期：2009-10-01 00:00:00
abstract：:Paracoccidioidomycosis (PCM) is a systemic granulomatous disease caused by Paracoccidioides brasiliensis (Pb), a thermal dimorphic fungus. Its major antigen is a 43-kDa glycoprotein. Gp43 embodies different functions: it participates in evasion mechanisms during the installation of primary infection, stimulates granul...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2008.10.011
更新日期：2009-01-01 00:00:00
abstract：:We previously found that, in a mouse model of Chagas cardiomyopathy, 18% of the 9390 quantified unigenes were significantly regulated by Trypanosoma cruzi infection. However, treatment with bone marrow-derived mononuclear cells (MNCs) resulted in 84% transcriptomic recovery. We have applied new algorithms to reanalyze...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2017.11.003
更新日期：2018-03-01 00:00:00
abstract：:We investigated the epidemiology of antibiotic resistance and virulence properties among Pseudomonas aeruginosa clinical isolates collected in 1999 from patients hospitalized in the intensive care units of the centre hospitalier d'Orléans, in France. We compared the totality of the strains from mechanically ventilated...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/s1286-4579(02)01579-4
更新日期：2002-05-01 00:00:00
abstract：:Production of inflammatory cytokines and type I interferons by mammalian cells is mediated through virus-specific activation of Toll-like receptors (TLRs). Known roles for different TLRs and speculation as to their roles in viral pathogenesis and immunity are discussed in this review. ...
journal_title：Microbes and infection
pub_type： 杂志文章,评审
doi：10.1016/j.micinf.2004.08.013
更新日期：2004-12-01 00:00:00
abstract：:Lactobacilli are normal inhabitants of our microbiota and are known to protect against pathogens. Neisseria gonorrhoeae is a human specific pathogenic bacterium that colonises the urogenital tract where it causes gonorrhoea. In this study we analysed early interactions between lactobacilli and gonococci and investigat...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2008.07.032
更新日期：2008-10-01 00:00:00
abstract：:Anaerobic bacteria can cause a variety of endogenous infections in children. Because of their fastidious nature, they are difficult to isolate from infectious sites, and are often overlooked. Anaerobic infections can occur in all body sites, including the central nervous system, oral cavity, head and neck, chest, abdo...
journal_title：Microbes and infection
pub_type： 杂志文章,评审
doi：10.1016/s1286-4579(02)01656-8
更新日期：2002-10-01 00:00:00
abstract：:Genome sequences of 36 Rickettsia and Orientia were analyzed using Formal Order Analysis (FOA). This approach takes into account arrangement of nucleotides in each sequence. A numerical characteristic, the average distance (remoteness) - "g" was used to compare of genomes. Our results corroborated previous separation ...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2015.09.012
更新日期：2015-11-01 00:00:00
abstract：:Although the pathogenesis of periodontal disease (PD) is not well known, cytokines, chemotactic factors and inflammatory cells are certainly involved in the disease outcome. Here, we characterized the evolution of the PD induced by Actinobacillus actinomycetemcomitans in mice, showing that oral inoculation of these ba...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2005.01.012
更新日期：2005-04-01 00:00:00
abstract：:The bacteria-phagocyte interaction is of central importance in Salmonella pathogenesis. Immediately following phagocytosis, the NADPH phagocyte oxidase complex assembles in vesicles and produces highly toxic reactive oxygen species that play a major role in initial Salmonella killing by phagocytes. However, Salmonella...
journal_title：Microbes and infection
pub_type： 杂志文章,评审
doi：10.1016/s1286-4579(01)01492-7
更新日期：2001-11-01 00:00:00
abstract：:The strategies that allow Brucella abortus to persist for years inside macrophages subverting host immune responses are not completely understood. Immunity against this bacterium relies on the capacity of IFN-γ to activate macrophages, endowing them with the ability to destroy intracellular bacteria. We report here th...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2010.10.020
更新日期：2011-03-01 00:00:00
