Abstract:
:This study analyzed macrophage inflammatory protein-2 (MIP-2) production and neutrophil recruitment in urinary tract in response to Pseudomonas aeruginosa in an ascending model of urinary tract infection (UTI) in mice. Both planktonic and biofilm cells of P. aeruginosa were used for inducing UTI in mice. MIP-2 levels determined in urine, bladder and kidney showed maximum MIP-2 production 6 h postinfection, which correlated with neutrophil recruitment. Biofilm cells showed significantly more MIP-2 production and neutrophil recruitment. However, no correlation between bacterial numbers and neutrophil recruitment was observed in urine and kidney tissue. The role of MIP-2 and neutrophils in relation to the persistence of P. aeruginosa in the urinary tract of mice is discussed.
journal_name
Microbes Infectjournal_title
Microbes and infectionauthors
Mittal R,Chhibber S,Sharma S,Harjai Kdoi
10.1016/j.micinf.2004.08.008subject
Has Abstractpub_date
2004-11-01 00:00:00pages
1326-32issue
14eissn
1286-4579issn
1769-714Xpii
S1286-4579(04)00280-1journal_volume
6pub_type
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journal_title:Microbes and infection
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doi:10.1016/j.micinf.2006.08.013
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