Abstract:
:Toll-like receptors (TLRs) play an important role in the innate recognition of pathogens by dendritic cells (DCs) and in the induction of immune responses. However, relatively little is known about their functions in innate/acquired responses to complex eukaryotic microorganisms, including helminth parasites. That Schistosoma mansoni eggs activate myeloid DCs through TLR2 and TLR3 has been shown by us and others, but the consequences of this combined activation are still unknown. We show that the engagement of both TLR2 and TLR3 by schistosome eggs is important for the production of inflammatory cytokines and interferon-stimulated genes, such as some chemokines, by DCs. Strikingly, DCs sensitized with ovalbumin in the presence of parasite eggs dramatically reduce the release of Th2-type cytokines by ovalbumin-specific T lymphocytes, an effect that fully depends on TLR3. Finally, although TLR2 and TLR3 have no role in host resistance and in egg-induced granuloma formation in S. mansoni-infected mice, they individually and additionally increase the Th1/Th2 balance of the immune response. Thus, TLR2 and TLR3 sensing is required to shape the immune response during murine schistosomiasis, but is dispensable to control infection and pathology.
journal_name
Microbes Infectjournal_title
Microbes and infectionauthors
Vanhoutte F,Breuilh L,Fontaine J,Zouain CS,Mallevaey T,Vasseur V,Capron M,Goriely S,Faveeuw C,Ryffel B,Trottein Fdoi
10.1016/j.micinf.2007.09.013subject
Has Abstractpub_date
2007-11-01 00:00:00pages
1606-13issue
14-15eissn
1286-4579issn
1769-714Xpii
S1286-4579(07)00304-8journal_volume
9pub_type
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