Abstract：
:Haemolytic uraemic syndrome (HUS), which is caused by Shiga toxin (Stx)-producing Escherichia coli, is the commonest cause of acute renal failure in childhood. It is widely believed that HUS develops following the release of Stx, an AB5 toxin that inhibits protein synthesis and has a direct toxic effect on the kidney endothelium. There remains, however, a mismatch between the current understanding of the pathogenesis of HUS and the evolution of the clinical signs of the disease. Our hypothesis is that Stx-mediated immune cell activation in the gut is the missing link in the pathogenesis of this condition, initiating the characteristic renal pathology of HUS either alone or in synergy with Stx. Validation of this hypothesis could lead to a targeted anti-inflammatory approach aimed at modulating immune cell function in HUS.
journal_name
Trends Microbioljournal_title
Trends in microbiologyauthors
Heyderman RS,Soriani M,Hirst TRdoi
10.1016/s0966-842x(01)02045-5subject
Has Abstractpub_date
2001-06-01 00:00:00pages
262-6issue
6eissn
0966-842Xissn
1878-4380pii
S0966-842X(01)02045-5journal_volume
9pub_type
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