Abstract:
:Stromal cell-derived factor 1alpha (SDF-1alpha) is a chemokine that has been shown to prevent infection of T-tropic HIV strains and is a possible substrate of CD26/dipeptidyl peptidase IV (DPPIV). In this study, we show that SDF-1alpha was cleaved at the N-terminal region by CD26/DPPIV and as a result the inhibitory activity of SDF-1alpha against HIV infection disappeared. Moreover, the chemotactic activity of SDF-1alpha also disappeared specifically by DPPIV activity of recombinant soluble CD26. These results suggested that dissemination of T-tropic HIV strains in vivo may be facilitated by CD26/DPPIV via inactivation of functional SDF-1alpha.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Ohtsuki T,Hosono O,Kobayashi H,Munakata Y,Souta A,Shioda T,Morimoto Cdoi
10.1016/s0014-5793(98)00763-7subject
Has Abstractpub_date
1998-07-17 00:00:00pages
236-40issue
2eissn
0014-5793issn
1873-3468pii
S0014-5793(98)00763-7journal_volume
431pub_type
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