Abstract:
:It has long been known from fluorescence recovery after photobleaching experiments that the mobility of most cell surface receptors is much smaller than expected for free diffusion of proteins in a fluid lipid bilayer. Single-particle tracking experiments are currently revealing the complexity of the constraints to free diffusion. Evidence has been obtained for several different processes: domain-limited diffusion, temporary confinement and anomalous diffusion. The type of motion exhibited by a given receptor will profoundly influence the rate of any functional process which requires movement in the plane of the membrane. In particular, anomalous diffusion greatly reduces the distance travelled by a receptor on a time scale of minutes.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Cherry RJ,Smith PR,Morrison IE,Fernandez Ndoi
10.1016/s0014-5793(98)00595-xsubject
Has Abstractpub_date
1998-06-23 00:00:00pages
88-91issue
1-2eissn
0014-5793issn
1873-3468pii
S0014-5793(98)00595-Xjournal_volume
430pub_type
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