Abstract:
:Ovulation is a complex process initiated by the surge of the pituitary luteinizing hormone (LH) that provokes the expression of specific genes. We report herein the isolation and characterization of an ovulation-associated, ovary-specific novel isoform of epoxide hydrolase 2 (Ephx2), Ephx2C. This variant is exclusively expressed in the granulosa cells of preovulatory mouse ovarian follicles. The LH-induced expression of Ephx2C is mediated by the protein kinase A and partially by the protein kinase C signaling pathways. The involvement of p38 kinase has also been demonstrated.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Shkolnik K,Ben-Dor S,Galiani D,Hourvitz A,Dekel Ndoi
10.1016/j.febslet.2007.09.016subject
Has Abstractpub_date
2007-10-16 00:00:00pages
4891-8issue
25eissn
0014-5793issn
1873-3468pii
S0014-5793(07)00992-1journal_volume
581pub_type
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