Abstract:
:To clarify the function of osteopontin in osteoblast differentiation, we have examined the signal transduction pathway in an osteoblastic cell line (UMR106-6) bound to osteopontin, fibronectin, vitronectin and collagen type I surfaces. This was done by investigating the production and autophosphorylation of focal adhesion kinase (FAK) and the expression of alkaline phosphatase (ALP) at the transcription level. Results suggest that osteopontin was not only responsible for the autophosphorylation of FAK but regulated the expression of ALP, which was strongly correlated with FAK activity. These results suggest that osteopontin might act as a trigger in the early differentiation of osteoblasts.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Liu YK,Uemura T,Nemoto A,Yabe T,Fujii N,Ushida T,Tateishi Tdoi
10.1016/s0014-5793(97)01498-1subject
Has Abstractpub_date
1997-12-22 00:00:00pages
112-6issue
1eissn
0014-5793issn
1873-3468pii
S0014-5793(97)01498-1journal_volume
420pub_type
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