Abstract:
:Bombesin (BN) and its mammalian counterpart gastrin-releasing peptide act as neuroregulatory hormones and tissue-specific growth factors, and have been implicated as peripheral and central satiety-inducing agents. In the present study, the immunohistochemical expression of BN in submandibular, sublingual and parotid glands of rats was examined 10 days after 5 consecutive days with daily doses of 6-8 Gy irradiation. Radioimmunoassay (RIA) methods were also used. Immunoreactive granular structures were observed within duct cells of both controls and irradiated animals. In the parenchyma of irradiated animals, very few nerve fibres showing BN-like immunoreactivity were observed. The RIA analysis showed that the content of BN-like material significantly increased in submandibular and parotid glands in response to irradiation. The results suggest that mainly a non-neural form of BN is detected in the salivary glands in the immunohistochemical analysis. Thus, the immunohistochemical observations suggest that BN-like peptides may be present in the duct system, where they may be constituents of the saliva. The observations of an increase in BN content in response to irradiation are of interest as BN has mitogenic effects, may stimulate secretion and contributes to satiety.
journal_name
Neuropeptidesjournal_title
Neuropeptidesauthors
Aalto Y,Kjörell U,Henriksson R,Franzén L,Forsgren Sdoi
10.1016/s0143-4179(97)90086-xsubject
Has Abstractpub_date
1997-04-01 00:00:00pages
167-73issue
2eissn
0143-4179issn
1532-2785pii
S0143-4179(97)90086-Xjournal_volume
31pub_type
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