Abstract:
:Familial dysautonomia (FD) patients have diminished sensory C-fibers. Calcitonin gene related peptide (CGRP) is a widely distributed neuropeptide and prominent neurotransmitter in C-fibers. We show that plasma CGRP levels measured by radioimmunoassay is significantly lower in 51 FD patients compared to controls (P<0.001). In 11/51 FD patients with FD crisis and in 19/51 FD patients with pneumonia, the mean CGRP levels rose significantly as compared to their baseline (P<0.003, P<0.001, respectively). The deficiency of CGRP in FD patients is consistent with their depletion of C-fibers, and may explain some of their symptoms, either directly or via modulation of sympathetic activity.
journal_name
Neuropeptidesjournal_title
Neuropeptidesauthors
Maayan C,Becker Y,Gesundheit B,Girgis SIdoi
10.1054/npep.2001.0863keywords:
subject
Has Abstractpub_date
2001-06-01 00:00:00pages
189-95issue
3-4eissn
0143-4179issn
1532-2785pii
S0143-4179(01)90863-7journal_volume
35pub_type
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