Abstract:
:Dermorphin (Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH2), a naturally occurring peptide isolated from arboreal frog skin, is endowed with outstanding structural and biological features. It has no structural community with the sequence of mammalian opioid peptides and is a unique example of a D-aminoacid containing peptide which is synthesized via ribosomal route. Dermorphin is the most potent of the opioid peptides or opiates in producing long lasting analgesia and catalepsy. Since most amphibians' secretory peptides have counterparts in the mammalian central nervous system and gastrointestinal tract, we have developed a sensitive enzyme immunoassay that can detect 1 pg dermorphin to verify the possibility of dermorphin or dermorphin-related peptides occurrence in mammalian tissues. Dermorphin-related peptides were purified by fast protein liquid chromatography followed by reverse phase high pressure liquid chromatography. Identification was achieved by chromatographic comparison with synthetic standards and immunological analysis. A peptide behaving like authentic dermorphin was detected (2 ng/g) in rat small intestine. Immunoreactive species of higher Mr were also detected in the brain, adrenal glands and gastrointestinal tract, they may represent extended forms of dermorphin or homologous peptides.
journal_name
Neuropeptidesjournal_title
Neuropeptidesauthors
Mor A,Delfour A,Amiche M,Sagan S,Nicolas P,Grassi J,Pradelles Pdoi
10.1016/0143-4179(89)90021-8subject
Has Abstractpub_date
1989-01-01 00:00:00pages
51-7issue
1eissn
0143-4179issn
1532-2785pii
0143-4179(89)90021-8journal_volume
13pub_type
杂志文章相关文献
NEUROPEPTIDES文献大全abstract::The level of opioid peptides in several brain areas and in the pituitary was estimated in WAG/Rij rats, which are considered to be a genetic animal model for human absence epilepsy. In comparison with three groups of non-epileptic controls, these epileptic rats had an elevated level of the proenkephalin-derived peptid...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(92)90037-w
更新日期:1992-03-01 00:00:00
abstract::Quantitative evaluation of octadecaneuropeptide-like immunoreactivity (ODN-Li) was carried out in hippocampus, cortex and cerebellum of group-reared or three month isolated male Wistar rats, whether muricidal or not. ODN-Li was lower in cortex and cerebellum of isolated animals, (mainly in muricidal) than of group-rea...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(91)90116-z
更新日期:1991-07-01 00:00:00
abstract::Plasma levels of ghrelin, an orexigenic peptide, are increased during conditions of chronic starvation, such as in patients with anorexia nervosa. However, it is not known whether such increase can be related to the number of preproghrelin mRNA-expressing cells in the stomach, and if chronic starvation may activate a ...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2015.04.003
更新日期:2015-06-01 00:00:00
abstract::D-Arg containing dipeptides, H-Tyr-D-Arg-OMe and H-Tyr (Et)-D-Arg-OMe, and D-Arg2 substituted N-terminal tetrapeptides of dermorphin, H-Tyr-D-Arg-Phe-Gly-OEt and H-Tyr (Et)-D-Arg-Phe-Gly-OEt administered intracerebroventricularly exhibited dose-dependent antinociceptive activities in mice as measured by the tail press...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(84)90001-5
更新日期:1984-06-01 00:00:00
abstract::[3H]-Dynorphin A (1-8) was degraded in brain homogenates at 25 degrees and even at 0 degree C. The peptidase inhibitors bestatin and captopril almost completely protected[3H]-dynorphin A (1-8) from degradation at 0 degree C but had only little effect on binding at this temperature. At 25 degrees C, the binding of [3H]...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(85)90072-1
更新日期:1985-02-01 00:00:00
abstract::Neuropeptide Y (NPY) causes anxiolytic- and antidepressant-like effects after central administration in rodents. These effects could theoretically be utilized in future gene therapy for anxiety and depression using viral vectors for induction of overexpression of NPY in specific brain regions. Using a recombinant aden...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2014.09.004
更新日期:2014-12-01 00:00:00
abstract::Accumulating evidence suggests that blood borne hormones modulate brain mechanisms regulating blood pressure. This appears to be mediated by the circumventricular organs which are located in the walls of the brain ventricular system and lack the blood-brain barrier. Recent evidence shows that neurons of the circumvent...
journal_title:Neuropeptides
pub_type: 杂志文章,评审
doi:10.1016/j.npep.2014.01.003
更新日期:2014-04-01 00:00:00
abstract::The effects of graded amounts of centrally injected [intracerebroventricular, i.c.v.] oxytocin [OXT] have been studied on the steady-state level and pargyline-induced accumulation of serotonin [5-HT] in the hypothalamus, mesencephalon and dorsal hippocampus of rats. OXT only weakly affected the steady-state level of 5...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(84)90125-2
更新日期:1984-03-01 00:00:00
abstract::The neurokinin-1 (NK-1) receptor interacts with peptides that belong to the tachykinin family. NK-1 is inducible in bone marrow (BM) stroma. In neural cells, its expression is high to constitutive. Screening of three cDNA libraries indicated that this different in NK-1 expression in neural and BM cells could not be ex...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1054/npep.2002.0869
更新日期:2002-02-01 00:00:00
abstract::The effects of the GABAergic drugs nipecotic acid, Gabrene, baclofen and metatolylcarbamide (MTC), when given alone or in combination at subthreshold doses with AT II also at a subthreshold dose effective on PTZ-kindling in mice were studied. PTZ-kindling was provoked by intraperitoneal (i.p.) injections of PTZ (40 mg...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(95)90071-3
更新日期:1995-01-01 00:00:00
abstract::We have previously shown that one of the major determinants directing the expression of the preprotachykinin-A (TAC1) gene, which encodes the neuropeptide substance P, is the transcription factor Neuronal Restrictive Silencer Factor (NSRF), which is also termed Repressor Element-1 Silencing Factor (REST). In rodent mo...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2009.05.004
更新日期:2009-08-01 00:00:00
abstract::Down syndrome is the most common genetic disorder associated with mental retardation. Subjects and mice models for Down syndrome (such as Ts65Dn) show defects in the formation of neuronal networks in both the hippocampus and the cerebral cortex. The principal neurons display alterations in the morphology, density and ...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2011.10.002
更新日期:2012-02-01 00:00:00
abstract::Social recognition is the sensitive domains of complex behavior critical for identification, interpretation and storage of socially meaningful information. Social recognition develops throughout childhood and adolescent, and is affected in a wide variety of psychiatric disorders. Recently, new data appeared on the mol...
journal_title:Neuropeptides
pub_type: 杂志文章,评审
doi:10.1016/j.npep.2018.09.003
更新日期:2018-12-01 00:00:00
abstract::The recent surge of scientific interest in 5-hydroxytryptamine3 (5-HT3) receptors can be attributed largely to the rapid increase in the number of potent and selective 5-HT3 receptor antagonists. The availability of a large variety of chemically diverse 5-HT3 compounds allows for a unique opportunity to apply computer...
journal_title:Neuropeptides
pub_type: 杂志文章,评审
doi:10.1016/0143-4179(91)90079-x
更新日期:1991-07-01 00:00:00
abstract::In binding assays with homogenates of the myenteric plexus-longitudinal muscle of the guinea-pig, beta-funaltrexamine is more potent at displacing mu-binding than kappa-binding. Incubation of homogenates with beta-funaltrexamine (100 or 1000 nM) for 30 min at 37 degrees C followed by repeated washing with drug-free Tr...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(84)90054-4
更新日期:1984-12-01 00:00:00
abstract::In previous studies, membranes from chicken gastrointestinal tissues failed to bind appreciable levels of 125I-APP labeled at the C-terminus. In order to address the suggestion that this was due to steric hindrance of the critical C-terminus, N-terminally labeled 125I-APP was utilized in in vitro membrane binding assa...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(92)90026-s
更新日期:1992-04-01 00:00:00
abstract::Cerebral amyloid-beta protein (Abeta) deposition and associated neuroinflammation and apoptosis are increasingly recognized as an important component leading to cognitive impairment in Alzheimer's disease (AD). Humanin (HN) and its derivative, S14G-HN (HNG), are best known for their ability to suppress neuronal death ...
journal_title:Neuropeptides
pub_type: 杂志文章,收录出版
doi:10.1016/j.npep.2008.08.004
更新日期:2008-10-01 00:00:00
abstract::The effects of several protein modifying reagents, including phenoxybenzamine, N-ethylmaleimide (NEM), 5,5'-dithiobis (2-nitro)--benzoic acid (DTNB), p-chloromercuryphenyl sulfonic acid (PCMP) and p-bromophenacylbromide (PBPB), on the binding of 125I-Bolton Hunter substance P (125I-BHSP), 125I-Bolton Hunter eledoisin ...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(87)90053-9
更新日期:1987-02-01 00:00:00
abstract::The neuropeptide galanin is widely expressed in both the central and peripheral nervous systems. However there is limited understanding of how individual galanin receptor (GalR1, 2, and 3) subtypes mediate the physiological activity of galanin in vivo. To address this issue we utilized NAX-5055, a systemically availab...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2015.01.001
更新日期:2015-04-01 00:00:00
abstract::Galanin, a 29 residue peptide found in the hypothalamus, causes orexigenic effects in a variety of species. In the present study, we investigated appetite-associated effects of galanin in chicks from lines which have been selected from a common founder population for either low or high body weight. The low line consis...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2012.11.003
更新日期:2013-08-01 00:00:00
abstract::Oxytocin, either intraperitoneally injected (200 ng/rat) or intracerebroventricularly infused (1 ng/rat in 4 microliters saline) 60 and 15 min respectively before testing, significantly increased the lordosis response to the mounting male of ovariectomized, estrogen/progesterone treated rats. The intracerebroventricul...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(85)90095-2
更新日期:1985-06-01 00:00:00
abstract::Development of transgenic mice overexpressing GH and GHR-KO mice with GH resistance provided novel animal models for study of the somatotropic axis and for identifying GH actions that may be relevant to its current and contemplated use in medicine and agriculture. Studies of phenotypic characteristics of these animals...
journal_title:Neuropeptides
pub_type: 杂志文章,评审
doi:10.1054/npep.2002.0889
更新日期:2002-04-01 00:00:00
abstract::Nerve growth factor (NGF) was reported to be increased in the serum and skin of atopic dermatitis (AD) patients, to the extent that serum nerve growth factor levels were proposed to serve as a marker of disease severity. We studied NGF levels in the serum and dermis using skin microdialysis and attempted to correlate ...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2011.07.008
更新日期:2011-12-01 00:00:00
abstract:OBJECTIVE:To explore the orexinergic pathway from the lateral hypothalamus (LHA) to the nucleus accumbens (NAc) and its regulation on the palatable food intake. METHODS:Fluorescent gold retrograde tracing combined with fluoro-immunohistochemical staining were used to observe the projection of orexinergic neurons from ...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2020.102028
更新日期:2020-04-01 00:00:00
abstract::The present study is designed to elucidate the involvement of neuronal mechanisms in corticotropin-releasing factor (CRF)-induced anti-oedema effects. Oedema was induced in the rat hind paw by subcutaneous injection of 3 nmol of serotonin (5-HT). A single dose of CRF (9.4, 37.5 or 75 pmol) was given either ipsilateral...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1054/npep.2000.0800
更新日期:2000-04-01 00:00:00
abstract::Various studies have shown a relationship between nerves and bones. Recent evidence suggests that both sensory and sympathetic nerves affect bone metabolism; however, little is known about how neuropeptides are involved in the differentiation of pluripotent stem cells into osteoblastic (OB) cells. To evaluate the puta...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2014.10.004
更新日期:2014-12-01 00:00:00
abstract::We have found that Neuropeptide Y is colocalized with enkephalin in bovine adrenal chromaffin cells. The two peptides can be found in the same granules in those cells where they coexist. These cells correspond to the adrenergic subpopulation of chromaffin cells since they contain the epinephrine synthetic enzyme, phen...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(86)90025-9
更新日期:1986-05-01 00:00:00
abstract::The aim of the present investigation was to determine if chronic activation of kappa-opioid receptor induces development of tolerance and dependence to kappa-opioid agonists on the isolated right atrium of the rat. Tolerance to the kappa-agonist was induced by chronic administration of U-50,488H, a selective kappa-ago...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/s0143-4179(97)90047-0
更新日期:1997-10-01 00:00:00
abstract::We have described the binding of [125I]endothelin-1 (ET-1) to cultured rat cerebellar granule cells. Binding of [125I]ET-1 was specific, saturable, and time-dependent. Scatchard analysis of saturation binding data indicated a single class of high affinity binding site with a KD of 95 pM, and a Bmax of 8110 receptors/c...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(91)90005-4
更新日期:1991-02-01 00:00:00
abstract::Neuropeptide Y (NPY) is involved in multiple processes such as behavior, energy and bone metabolism. Previous studies have relied on global NPY depletion to examine its effects on bone. However, this approach is unable to distinguish the central or local source of NPY influencing bone. Our aim was to identify which ce...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2018.11.009
更新日期:2019-02-01 00:00:00