Acute and persistent effects of beta-funaltrexamine on the binding and agonist potencies of opioids in the myenteric plexus of the guinea-pig ileum.

abstract：:Brain extracts from 3 to 4 day old final (eighth) instar larvae of Opisina arenosella (Lepidoptera) stimulate amylase release from midgut preparations maintained in vitro. This effect of the brain extract was both time and dose dependent. The brain factor stimulating enzyme release may be a peptide as it is heat stabl...

journal_title：Neuropeptides

authors： Harshini S,Reshmi V,Sreekumar S

更新日期：2003-06-01 00:00:00

abstract：:Acid extracts from mouse Neuroblastoma x rat Glioma hybrid cells have been purified by means of Sep-Pak C-18 and fractionated by high performance liquid chromatography. Each fraction has been submitted to a sensitive beta-endorphin radioimmunoassay and an immunoreactivity peak at camel beta-endorphin retention time wa...

journal_title：Neuropeptides

authors： Di Marzo V,Etienne A,Marino G,Morris HR,Palmisano A

更新日期：1985-03-01 00:00:00

abstract：OBJECTIVE:Neuropeptide Y, a widely circulating neurotransmitter, plays a pivotal role in energy balance, immunomodulation and asthma, and several NPY polymorphisms are promising genetic risk factors for asthma and obesity. We explored the associations of candidate NPY gene polymorphisms with prevalent asthma and its re...

journal_title：Neuropeptides

authors： Lu Y,Andiappan AK,Lee B,Ho R,Lim TK,Kuan WS,Goh DY,Mahadevan M,Sim TB,Wang Y,Van Bever HP,Rotzschke O,Larbi A,Ng TP

更新日期：2016-10-01 00:00:00

abstract：:The hypocretins/orexins (hcrts) are two recently described neuropeptides derived from the same precursor and expressed in a few thousand neurons in the perifornical area of the lateral hypothalamus, which project throughout the brain. The hypocretins bind to two G-protein coupled receptors with different selective aff...

journal_title：Neuropeptides

authors： de Lecea L,Sutcliffe JG,Fabre V

更新日期：2002-04-01 00:00:00

abstract：:Oxytocin (OXT), a nonapeptide hormone of posterior pituitary, reaches the central nervous system from systemic blood circulation with a difficulty because of the blood-brain barrier (BBB). The interest has been expressed in the use of the nasal route for delivery of OXT to the brain directly, exploiting the olfactory ...

journal_title：Neuropeptides

authors： Wang YL,Yuan Y,Yang J,Wang CH,Pan YJ,Lu L,Wu YQ,Wang DX,Lv LX,Li RR,Xue L,Wang XH,Bi JW,Liu XF,Qian YN,Deng ZK,Zhang ZJ,Zhai XH,Zhou XJ,Wang GL,Zhai JX,Liu WY

更新日期：2013-04-01 00:00:00

abstract：:Stretching-yawning syndrome (SYS) and penile erections (PE) are typical components of the behavioral picture induced by intracerebroventricular (i.c.v.) injection of ACTH 1-24. The present study shows that pretreatment with alpha-difluoromethylornithine (DFMO), and irreversible inhibitor of mammalian ornithine decarbo...

journal_title：Neuropeptides

authors： Genedani S,Bernardi M,Bertolini A

更新日期：1984-05-01 00:00:00

abstract：:Possible positive reinforcing and aversive effects of intraperitoneally (ip) administered substance P (SP) and its C-terminal heptapeptide analog [pGlu5, MePhe8, Sar9]-SP5-11 (DIME-C7) were investigated in rats. The 'conditioned corral preference and avoidance procedure' was used for assessing positive and negative re...

journal_title：Neuropeptides

authors： Hasenöhrl RU,Gerhardt P,Huston JP

更新日期：1990-12-01 00:00:00

abstract：:Rat/mouse hemokinin-1 (r/m HK-1) has been identified as a member of the tachykinin family and its effect in colonic contractile activity remains unknown. We investigated the effects and mechanisms of actions of r/m HK-1 on the mouse colonic contractile activity in vitro by comparing it with that of substance P (SP). R...

journal_title：Neuropeptides

authors： Kong ZQ,Han M,Yang WL,Zhao YL,Fu CY,Tao Y,Chen Q,Wang R

更新日期：2009-06-01 00:00:00

abstract：:A human brain aminopeptidase, which hydrolyses low molecular weight enkephalin-containing peptides (ECPs), was purified to apparent homogeneity from the homogenate of human brain. The enzyme purification involved DEAE-cellulose chromatography and preparative polyacrylamide gel electrophoresis. The purified aminopeptid...

journal_title：Neuropeptides

authors： Duarte GI,Souza FG,Bruno JA,Camargo AC,Carvalho KM

更新日期：1988-08-01 00:00:00

abstract：:Neuropeptide Y (NPY) -receptor subtypes were studied in the rat kidney in vivo by systemic administration of NPY, the two agonists [Leu(31), Pro(34)]NPY (Y1-receptor agonist) and NPY (13-36) (Y2-receptor agonist), or the Y1-receptor antagonist BIBP 3226. Effects on mean arterial blood pressure (MAP) and renal arterial...

journal_title：Neuropeptides

authors： Modin A,Malmström RE,Meister B

更新日期：1999-08-01 00:00:00

abstract：:The effects of forskolin or phorbol-13-myristate (PMA) injected intrathecally (i.t.) or intracerebroventricularly (i.c.v.) on the inhibition of the tail-flick and hotplate responses induced by morphine or beta-endorphin administered i.c.v. were studied. Animals pretreated with forskolin (20 micrograms) i.t. for 10 min...

journal_title：Neuropeptides

authors： Suh HW,Song DK,Sim YB,Chung KM,Kim YH

更新日期：1996-04-01 00:00:00

abstract：:The present study is designed to elucidate the involvement of neuronal mechanisms in corticotropin-releasing factor (CRF)-induced anti-oedema effects. Oedema was induced in the rat hind paw by subcutaneous injection of 3 nmol of serotonin (5-HT). A single dose of CRF (9.4, 37.5 or 75 pmol) was given either ipsilateral...

journal_title：Neuropeptides

authors： Veraksits A,Bileviciute-Ljungar I,Maaroos J,Vasar E,Lundeberg T

更新日期：2000-04-01 00:00:00

abstract：:The distributions of four prodynorphin-derived peptides, dynorphin A (1-17), dynorphin A (1-8), dynorphin B, and alpha-neo-endorphin were determined in 10 cortical regions and the striatum of the old world monkey (Macaca nemestrina). alpha-neo-endorphin was the most abundant peptide in both cortex and striatum. The co...

journal_title：Neuropeptides

authors： Healy DJ,Meador-Woodruff JH

更新日期：1994-11-01 00:00:00

abstract：:Ghrelin (gh) is a peptide hormone that may affect learning and memory. There is some evidence that ghrelin can have antiepileptic effects. So we decided to investigate the possible effects of ghrelin on spatial memory following PTZ-induced seizures in male rats. Ninety male rats were divided into 9 groups including co...

journal_title：Neuropeptides

authors： Babri S,Amani M,Mohaddes G,Mirzaei F,Mahmoudi F

更新日期：2013-10-01 00:00:00

abstract：:In previous studies, membranes from chicken gastrointestinal tissues failed to bind appreciable levels of 125I-APP labeled at the C-terminus. In order to address the suggestion that this was due to steric hindrance of the critical C-terminus, N-terminally labeled 125I-APP was utilized in in vitro membrane binding assa...

journal_title：Neuropeptides

authors： Adamo ML,Hazelwood RL

更新日期：1992-04-01 00:00:00

abstract：:Information on the physiological functions of neuropeptide FF; NPFF, a morphine modulating octapeptide in avians is lacking. Thus, we designed a study to investigate the effects of central NPFF with particular emphasis on appetite-related processes. Cobb-500 chicks were intracerebroventricularly (ICV) injected with 0,...

journal_title：Neuropeptides

authors： Cline MA,Nandar W,Rogers JO

更新日期：2007-12-01 00:00:00

abstract：:To study the effect of septicaemia, the temporal changes in tissue adrenomedullin (AM) and preproAM mRNA levels were studied in the heart and blood vessels after lipopolysaccharide (LPS) injection. Radioimmunoassay and solution hybridization-RNase protection assays were used to follow the changes in AM and its mRNA le...

journal_title：Neuropeptides

authors： Li YY,Cheung BM,Wong LY,Hwang IS,Kumana CR,Tang F

更新日期：2005-04-01 00:00:00

abstract：:Neuropeptide Y (NPY) is involved in multiple processes such as behavior, energy and bone metabolism. Previous studies have relied on global NPY depletion to examine its effects on bone. However, this approach is unable to distinguish the central or local source of NPY influencing bone. Our aim was to identify which ce...

journal_title：Neuropeptides

authors： Wee NKY,Sinder BP,Novak S,Wang X,Stoddard C,Matthews BG,Kalajzic I

更新日期：2019-02-01 00:00:00

abstract：:We have measured cerebrospinal fluid (CSF) neuropeptide Y-like immunoreactivity (NPY-LI) and somatostatin-like immunoreactivity (SLI) in control subjects and in patients with various neurologic disorders. We observed a significant reduction in CSF SLI in control subjects over 60 years of age, compared with the younger...

journal_title：Neuropeptides

authors： Maeda K,Yasuda M,Kaneda H,Maeda S,Yamadori A

更新日期：1994-12-01 00:00:00

abstract：:Since there are conflicting reports regarding the effects of somatostatin (SS) on cyclic AMP levels in astrocytes derived from rat cerebral cortex and, to date, the SS binding to mature astrocytes is unknown, the present study has determined SS binding and its effect on cyclic AMP accumulation in a fresh astrocyte-ric...

journal_title：Neuropeptides

authors： Colás B,Arilla E,Prieto JP

更新日期：1992-09-01 00:00:00

abstract：:Two tachykinin peptides, substance P (SP) and hemokinin-1 (HK-1), and three transient receptor potential (TRP) channels, TRPV1, TRPA1 and TRPM8, are similarly localized in the spinal dorsal horn and dorsal root ganglion, suggesting that TRP channels may be related or modulated by these tachykinin peptides. Thus, to cl...

journal_title：Neuropeptides

authors： Naono-Nakayama R,Sunakawa N,Ikeda T,Nishimori T

更新日期：2010-02-01 00:00:00

abstract：:Tachykinins are a family of pronociceptive neuropeptides with a specific role in pain and inflammation. Several mechanisms regulate endogenous tachykinins and Substance P (SP) levels, including the differential expression of protachykinin mRNA and the controlled secretion of tachykinins from neurons. Proteolysis is su...

journal_title：Neuropeptides

authors： Saidi M,Kamali S,Beaudry F

更新日期：2016-10-01 00:00:00

abstract：:Cholecystokinin-B (CCK-8) is an octapeptide that was initially described in the gastrointestinal tract. Recent studies have shown that this peptide also has an extensive distribution in the central nervous system, including the cerebellum of the opossum. In addition to the protein, binding sites for CCK-8 also have be...

journal_title：Neuropeptides

authors： Bishop GA

更新日期：1996-12-01 00:00:00

abstract：:The distribution and modification of the tachykinins Substance P (SP) and neurokinin A (NKA), their precursor beta-preprotachykinins (beta-PPT) and the receptors involved in their activity, NK-1 and NK-2, were studied in trinitrobenzensulphonic acid (TNB) colitis. Rats were intrarectally treated with a 120 mg/ml of TN...

journal_title：Neuropeptides

authors： Evangelista S,Tramontana M,Maggi CA

更新日期：2008-10-01 00:00:00

abstract：:Noradrenaline (NA) has been implicated in both increase and reduction of anxiety. Selective destruction of nerve endings of the locus coeruleus projections by DSP-4 has been shown to reduce active behaviour in novel situations by enhancing anxiety. In the present study, DSP-4 (50 mg/kg) treatment reduced locomotor act...

journal_title：Neuropeptides

authors： Kask A,Eller M,Oreland L,Harro J

更新日期：2000-02-01 00:00:00

abstract：:Striatal neuropeptide Y-like immunoreactivity (NPY-LI) levels were investigated in naive rats after acute, subchronic (14 days) or chronic (28 days) intraperitoneal (i.p.) treatment with chlorpromazine (2 or 10mg/kg), haloperidol (0.5 or 2 mg/kg), (+/-)sulpiride (50 or 100 mg/kg) or clozapine (10 or 25 mg/kg), and in ...

journal_title：Neuropeptides

authors： Obuchowicz E,Turchan J

更新日期：1998-10-01 00:00:00

abstract：:There is now considerable evidence that putative neuropeptides are involved in epileptogenic processes. Neurotensin (NT), which affects neuronal excitability in many parts of the CNS, is potentially relevant to the kindling phenomenon, but has not previously been studied in the kindling model of epilepsy. This study c...

journal_title：Neuropeptides

authors： Shulkes A,Harris QL,Lewis SJ,Vajda JE,Jarrott B

更新日期：1988-02-01 00:00:00

abstract：:In the present study, electrophysiological recordings were made from hippocampal slices obtained from mice overexpressing galanin under the promoter for the platelet-derived growth factor-B (GalOE mice). In these mice, a particularly strong galanin expression is seen in the granule cell layer/mossy fibers. Paired-puls...

journal_title：Neuropeptides

authors： Zheng K,Kuteeva E,Xia S,Bartfai T,Hökfelt T,Xu ZQ

更新日期：2005-06-01 00:00:00

abstract：:We have used immunohistochemistry and in situ hybridization histochemistry to visualize CGRP and the mRNA encoding the CGRP precursor in the stomach. CGRP is present in nerve fibers in the mucosa. CGRP mRNA and CGRP itself are also found in non-neural cells in the lamina propria. These cells are likely to be macrophag...

journal_title：Neuropeptides

authors： Jakab G,Webster HD,Salamon I,Mezey E

更新日期：1993-02-01 00:00:00

abstract：:Injection of endothelin-1 (9 pmol) into the lateral cerebral ventricle of rats produced barrel-rotations, convulsions, tonic hindlimb extensions, facial clonus, and kinetic ataxia for up to 45 min. Quantitative metabolic autoradiographs produced from the [14C]deoxyglucose method and analyzed over 60 individual brain s...

journal_title：Neuropeptides

authors： Gross PM,Wainman DS,Espinosa FJ,Nag S,Weaver DF

更新日期：1992-04-01 00:00:00