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Neuronal mechanisms contribute to corticotropin-releasing factor-induced anti-oedema effect in the rat hind paw.

Abstract：

:The present study is designed to elucidate the involvement of neuronal mechanisms in corticotropin-releasing factor (CRF)-induced anti-oedema effects. Oedema was induced in the rat hind paw by subcutaneous injection of 3 nmol of serotonin (5-HT). A single dose of CRF (9.4, 37.5 or 75 pmol) was given either ipsilaterally or contralaterally 30 min before 5-HT injection and oedema formation was subsequently measured every 30 min for 5.5 h. Compared to saline pre-treatment CRF (37.5 pmol) reduced oedema formation for 3.5 h when given ipsilaterally, and at 1.5 h (9.33, 37.5 and 75 pmol) when injected contralaterally. Administration of CRF along with CRF receptor antagonist, alpha-helical CRF, abolished the anti-oedema effects of CRF. Sciatic nerve ligation on the injected side attenuated the ipsilateral CRF-induced anti-oedema effect when compared with saline pre-treatment and sham-operated rats. Ipsilateral pre-treatment with 37.5 pmol of CRF caused a reduction in hind paw temperature compared to treatment with saline. Results of the present study indicate that the nervous system contributes to CRF effects in 5-HT-induced oedema formation.

journal_name

Neuropeptides

journal_title

Neuropeptides

authors

Veraksits A,Bileviciute-Ljungar I,Maaroos J,Vasar E,Lundeberg T

doi

10.1054/npep.2000.0800

keywords:

subject

Has Abstract

pub_date

2000-04-01 00:00:00

pages

129-34

issue

2

eissn

0143-4179

issn

1532-2785

pii

S0143-4179(00)90800-X

journal_volume

34

pub_type

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