Abstract:
:Noradrenaline (NA) has been implicated in both increase and reduction of anxiety. Selective destruction of nerve endings of the locus coeruleus projections by DSP-4 has been shown to reduce active behaviour in novel situations by enhancing anxiety. In the present study, DSP-4 (50 mg/kg) treatment reduced locomotor activity and time spent in social interaction in rats placed into a novel environment together with an unfamiliar rat, indicating an anxiogenic-like effect. The effect of DSP-4 on time spent in social interaction was completely antagonized by intracerebroventricular administration of neuropeptide Y (NPY) (1 microg) which had no effect of its own on this measure. The present study thus supports the idea that DSP-4 pretreatment is anxiogenic in novel situations and suggests a functional relationship of NA- and NPY-using neural mechanisms in the regulation of social behaviour.
journal_name
Neuropeptidesjournal_title
Neuropeptidesauthors
Kask A,Eller M,Oreland L,Harro Jdoi
10.1054/npep.1999.0788keywords:
subject
Has Abstractpub_date
2000-02-01 00:00:00pages
58-61issue
1eissn
0143-4179issn
1532-2785pii
S0143-4179(99)90788-6journal_volume
34pub_type
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