解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Spermidine is a naturally occurring endogenous polyamine synthesized from diamine putrescine. It is a well-known autophagy inducer that maintains cellular and neuronal homeostasis. Healthy brain development and function are dependent on brain polyamine concentration. Polyamines interact with the opioid system, glutama...
journal_title:Neuropeptides
pub_type: 杂志文章,评审
doi:10.1016/j.npep.2020.102083
更新日期:2020-10-01 00:00:00
abstract::Exercise at different intensities is able to induce different physical and psychological statuses of the subjects. The β-endorphin (β-EP) in central nervous system is thought to play an important role in physical exercise. However, its expression patterns and physiological effects in the central nuclei under different...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2020.102048
更新日期:2020-08-01 00:00:00
abstract::Chronic stress induces the activation of hippocampal microglia, which produces many inflammatory mediators and mediates the occurrence of depression. Two phenotypes of microglia polarization, the classical M1 and alternative M2, play important regulatory roles in neuroinflammation and are involved in the occurrence an...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2020.102006
更新日期:2020-06-01 00:00:00
abstract::Abnormal aggregation of beta-amyloid (Aβ) peptide into amyloid plaques in the brain has been identified as one of the key factors in instigating AD pathogenesis. Inhibition of Aβ aggregation can be an important therapeutic strategy in disease management. In this work, we demonstrate the application of structure-based ...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2020.102030
更新日期:2020-06-01 00:00:00
abstract::Cocaine-regulated and amphetamine-regulated transcript (CART) is a neuropeptide with reported neuroprotective effects in ischemic cerebral injury. However, its mechanism has not yet been elucidated. Herein, we investigated the role and mechanism of CART in synaptic plasticity in neurons after ischemic cerebral stroke....
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2020.102023
更新日期:2020-06-01 00:00:00
abstract:OBJECTIVES:Postmenopausal osteoporosis (PMO) is a metabolic skeletal disorder with impaired bone density and bone quality in postmenopausal women. The aim of the present study was to investigate the correlation between neuropeptides, bone microstructure and pain threshold in ovariectomized (OVX) rats. METHODS:Female r...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2019.101995
更新日期:2020-06-01 00:00:00
abstract:OBJECTIVE:To explore the orexinergic pathway from the lateral hypothalamus (LHA) to the nucleus accumbens (NAc) and its regulation on the palatable food intake. METHODS:Fluorescent gold retrograde tracing combined with fluoro-immunohistochemical staining were used to observe the projection of orexinergic neurons from ...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2020.102028
更新日期:2020-04-01 00:00:00
abstract::The progesterone metabolite, allopregnanolone (AlloP), is a GABAA receptor modulating steroid and is known to have orexigenic and pro-obesity effects. The neurobiological mechanisms underpinning these effects are most likely due to enhanced GABAergic signaling in the lateral arcuate nucleus (ARC) and medial paraventri...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2019.101937
更新日期:2019-08-01 00:00:00
abstract::Recent studies have shown that oxytocin reduces food intake and body weight gain and promotes lipolysis in some species, including humans. Interestingly, these effects of oxytocin are more marked in obese individuals. Although the menopausal loss of ovarian function induces increased visceral adiposity and some metabo...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2019.03.002
更新日期:2019-06-01 00:00:00
abstract::Clinical and experimental evidence have demonstrated that, use of alcohol during pregnancy can interrupt brain development. Alcohol-induced neurocognitive deficits in offspring's are involved with activation of oxidative-inflammatory cascade joined with extensive apoptotic neurodegeneration in different brain regions ...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2019.01.001
更新日期:2019-04-01 00:00:00
abstract::Neuropeptide Y (NPY) is involved in multiple processes such as behavior, energy and bone metabolism. Previous studies have relied on global NPY depletion to examine its effects on bone. However, this approach is unable to distinguish the central or local source of NPY influencing bone. Our aim was to identify which ce...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2018.11.009
更新日期:2019-02-01 00:00:00
abstract::Lumbar disc herniation is a common cause of radicular pain, but the mechanism remains ambiguous and the treatment stays unsatisfied. Many studies revealed a traditional Chinese medicine puerarin may moderate chronic pain from diabetes and nerve injury. Thus far, the role and mechanism of puerarin in radicular pain is ...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2018.10.001
更新日期:2018-12-01 00:00:00
abstract::Social recognition is the sensitive domains of complex behavior critical for identification, interpretation and storage of socially meaningful information. Social recognition develops throughout childhood and adolescent, and is affected in a wide variety of psychiatric disorders. Recently, new data appeared on the mol...
journal_title:Neuropeptides
pub_type: 杂志文章,评审
doi:10.1016/j.npep.2018.09.003
更新日期:2018-12-01 00:00:00
abstract::The central control of feeding in animals depends upon the alternating actions of orexigenic and anorectic peptides. Studies at understanding the food intake mechanisms have emphasised the role of Neuropeptide Y as a potent orexigenic peptide in the brain. The aim of this study is to investigate the response of NPY sy...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2018.06.001
更新日期:2018-10-01 00:00:00
abstract::Obesity is a global public health problem. Orexin and endocannabinoid signaling in the hypothalamus have been shown to regulate feeding and are promising molecular targets for obesity treatment. In this study, we attempted to analyze effects of orexin-A and endocannabinoid signaling modulation in the arcuate nucleus (...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2018.04.001
更新日期:2018-06-01 00:00:00
abstract::Bone cancer pain (BCP) is a common source of pain in patients with advanced stage and metastatic cancer; however, existing treatment for this kind of pain remains deficient. Being closely related to sensory change and inflammatory pain in both the central and peripheral nervous systems, endothelin A receptor (ETAR) pl...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2018.01.003
更新日期:2018-04-01 00:00:00
abstract::Alzheimer's disease (AD) is a progressive neurodegenerative disease that deeply affects patients, their family and society. Although scientists have made intense efforts in seeking the cure for AD, no drug available today is able to stop AD progression. In this context, compounds isolated from animal venom are potenti...
journal_title:Neuropeptides
pub_type: 杂志文章,评审
doi:10.1016/j.npep.2017.11.010
更新日期:2018-02-01 00:00:00
abstract::Germline ablation of VGF, a secreted neuronal, neuroendocrine, and endocrine peptide precursor, results in lean, hypermetabolic, and infertile adult mice that are resistant to diet-, lesion-, and genetically-induced obesity and diabetes (Hahm et al., 1999, 2002). To assess whether this phenotype is predominantly drive...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2016.12.005
更新日期:2017-08-01 00:00:00
abstract::Endothelins (ET) are a family of highly active neuropeptides with manifold influences via ET receptors (ETR) in both the peripheral and central nervous systems. We have shown previously that satellite glial cells (SGCs) in mouse trigeminal ganglia (TG) are extremely sensitive to ET-1 in evoking [Ca2+]in increase, appa...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2017.03.002
更新日期:2017-06-01 00:00:00
abstract::The galanin family currently consists of four peptides, namely galanin, galanin-message associated peptide, galanin-like peptide and alarin. Unlike galanin that signals through three different G protein-coupled receptors; GAL1, GAL2, and GAL3, binding at its N-terminal end, the cognate receptors for other members of t...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2017.03.005
更新日期:2017-06-01 00:00:00
abstract::Several studies suggest that prenatal ethanol exposure (PEE) facilitates ethanol intake. Opioid peptides play a main role in ethanol reinforcement during infancy and adulthood. However, PEE effects upon motor responsiveness elicited by an ethanol challenge and the participation of opioids in these actions remain to be...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2016.11.006
更新日期:2017-04-01 00:00:00
abstract::Recently, we demonstrated that brain neuropeptide Y (NPY) mRNA expression was increased in heat exposed chicks. However, the functions of brain NPY during heat stress are unknown. This study was conducted to investigate whether centrally administered NPY affects food intake, rectal temperature, monoamines, stress horm...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2016.11.008
更新日期:2017-04-01 00:00:00
abstract::Humanin (HN) is an endogenous 24-residue peptide. A highly potent HN derivative, S14G-HN, which has a substitution of serine 14 to glycine, reduced amyloid burden and suppressed cognitive impairment in a mouse model of Alzheimer's disease. S14G-HN also suppressed amnesia induced by a muscarinic receptor antagonist in ...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2016.10.008
更新日期:2017-04-01 00:00:00
abstract::Orexins are neuropeptides that are localized to neurons in the lateral and dorsal hypothalamus but its receptors are distributed to many different regions of the central nervous system. Orexins are implicated in a variety of physiological functions including sleep regulation, energy homeostats, and stress reactions. F...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2016.12.007
更新日期:2017-02-01 00:00:00
abstract::Multiple sclerosis (MS) is an autoimmune disease of the central nervous system characterized by brain inflammation, demyelination and axonal loss. Neuropeptide Y (NPY) has a critical role in the maintenance of homeostasis in the immune system and coping of stress condition. In the current study we analyzed 188 patient...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2016.08.004
更新日期:2016-12-01 00:00:00
abstract::Cholecystokinin (CCK) is a widely expressed neuropeptide system originally discovered in the gut. Both cerebral and peripheral neurons as well as endocrine I-cells in the small intestine process proCCK to tyrosyl-O-sulfated and α-carboxyamidated peptides. Recently, we reported that gut endocrine I-cells also synthetiz...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2016.08.003
更新日期:2016-12-01 00:00:00
abstract::Fracture repair is a complex yet well orchestrated regenerative process involving numerous signaling and cell types including osteoblasts. Here we showed that NPY, a neurotransmitter with regulatory functions in bone homeostasis, may contribute to the post-fracture bone healing in patients with traumatic brain injury-...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2016.09.005
更新日期:2016-12-01 00:00:00
abstract::Tachykinins are a family of pronociceptive neuropeptides with a specific role in pain and inflammation. Several mechanisms regulate endogenous tachykinins and Substance P (SP) levels, including the differential expression of protachykinin mRNA and the controlled secretion of tachykinins from neurons. Proteolysis is su...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2016.06.002
更新日期:2016-10-01 00:00:00
abstract:OBJECTIVE:Neuropeptide Y, a widely circulating neurotransmitter, plays a pivotal role in energy balance, immunomodulation and asthma, and several NPY polymorphisms are promising genetic risk factors for asthma and obesity. We explored the associations of candidate NPY gene polymorphisms with prevalent asthma and its re...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2016.07.003
更新日期:2016-10-01 00:00:00
abstract::The orally active, α-hemoglobin derived hemopressin (PVNFKFLSH, Hp(1-9)) and its truncated (PVNFKFL, Hp(1-7) and PVNFKF, Hp(1-6)) and extended ((R)VDPVNFKFLSH, VD-Hp(1-9) and RVD-Hp(1-9)) derivatives have been postulated to be the endogenous peptide ligands of the cannabinoid receptor type 1 (CB1). In an attempt to cr...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2016.02.001
更新日期:2016-08-01 00:00:00
abstract::Amylin (AMY) is a member of calcitonin family of peptides. In this study, the effects of intrathecal (i.t) injection of AMY on the inflammatory pain and on the cAMP accumulation in the rat spinal cells were investigated. By using AMY receptor antagonists, we also studied the pharmacology of AMY receptors in the spinal...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2015.12.011
更新日期:2016-06-01 00:00:00
abstract::Dynorphins are important neuropeptides with a central role in nociception and pain alleviation. Many mechanisms regulate endogenous dynorphin concentrations, including proteolysis. Proprotein convertases (PCs) are widely expressed in the central nervous system and specifically cleave at C-terminal of either a pair of ...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2015.10.008
更新日期:2016-06-01 00:00:00
abstract::Nesfatin-1, a newly discovered satiety peptide, has recently been reported to be involved in the stress response. Stress-induced expression of nesfatin-1 has been reported and few studies focus on its expression in the hypothalamus, which is the center of the stress response. To test our hypothesis that peripheral and...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2015.08.003
更新日期:2015-12-01 00:00:00
abstract::Prader-Willi syndrome (PWS) is the predominant genetic cause of obesity in humans and is associated with several behavioural phenotypes such as altered motoric function, reduced activity, and learning disabilities. It can include mood instability and, in some cases, psychotic episodes. Recently, the Snord116 gene has ...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2015.06.009
更新日期:2015-10-01 00:00:00
abstract::Plasma levels of ghrelin, an orexigenic peptide, are increased during conditions of chronic starvation, such as in patients with anorexia nervosa. However, it is not known whether such increase can be related to the number of preproghrelin mRNA-expressing cells in the stomach, and if chronic starvation may activate a ...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2015.04.003
更新日期:2015-06-01 00:00:00
abstract::The neuropeptide galanin is widely expressed in both the central and peripheral nervous systems. However there is limited understanding of how individual galanin receptor (GalR1, 2, and 3) subtypes mediate the physiological activity of galanin in vivo. To address this issue we utilized NAX-5055, a systemically availab...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2015.01.001
更新日期:2015-04-01 00:00:00
abstract::Nociceptin/Orphanin FQ (N/OFQ) is a 17-amino acid peptide that binds to the nociceptin receptor (NOP). N/OFQ and NOP receptors are expressed in numerous brain areas. The generation of specific agonists, antagonists and receptor-deficient mice or rats has enabled progress in elucidating the biological functions of N/OF...
journal_title:Neuropeptides
pub_type: 杂志文章,评审
doi:10.1016/j.npep.2015.03.005
更新日期:2015-04-01 00:00:00
abstract::PTHrP and its receptor PTHR1 are found in the CNS and peripheral nervous system. The presence of PTHrP mRNA has been detected in the superior cervical ganglion (SCG), but there are no data on the cellular distribution of PTHrP and PTHR1 in the SCG. Although it is known that ovarian activity and reproductive status inf...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2014.09.005
更新日期:2014-12-01 00:00:00
abstract::In critical patients, sepsis-induced muscle wasting is considered to be an important contributor to complications and mortality. Previous work mainly focuses on the peripheral molecular mechanism of muscle degradation, however little evidence exists for the role of central nervous system in the process. In the present...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2014.10.002
更新日期:2014-12-01 00:00:00
abstract::Neuropeptide Y (NPY) causes anxiolytic- and antidepressant-like effects after central administration in rodents. These effects could theoretically be utilized in future gene therapy for anxiety and depression using viral vectors for induction of overexpression of NPY in specific brain regions. Using a recombinant aden...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2014.09.004
更新日期:2014-12-01 00:00:00