Abstract：
OBJECTIVE:Neuropeptide Y, a widely circulating neurotransmitter, plays a pivotal role in energy balance, immunomodulation and asthma, and several NPY polymorphisms are promising genetic risk factors for asthma and obesity. We explored the associations of candidate NPY gene polymorphisms with prevalent asthma and its relationship with obesity in young adult asthma patients free of other chronic medical morbidity. METHODS:Five common gene variants of NPY (rs16147 (-399T/C), rs17149106 (-602G/T), rs16140 (+1000C/G), rs5573 (+1201A/G), rs5574 (+5327C/T)) previously validated to account for most of the NPY expression in vitro and in vivo were investigated in 126 physician-diagnosed asthma patients without other chronic medical morbidity and 182 healthy controls (21-35years). Plasma levels of NPY, adiponectin, and CRP were determined using ELISA, and IL-6 was measured by Luminex in a subgroup of 70 patients and 69 age- and sex-matched healthy controls. RESULTS:In logistic regression models controlling for gender and obesity, the CT genotype of rs5574 (OR=0.54, 95%CI: 0.30-0.89) and the GT genotype of rs17149106 (OR=5.58, 95%CI: 1.09-28.54) were significantly associated with asthma. No significant interaction between NPY SNP polymorphisms and obesity were detected. Plasma NPY level was correlated with adiponectin levels (p<0.05). Compared with the healthy controls, patients with asthma had higher BMI (p<0.001), adiponectin (p<0.05), IL-6 (p=0.001) and CRP (p<0.001), and lower NPY levels (p<0.01). CONCLUSIONS:The CT genotype of rs5574 and the GT genotype of rs17149106 are significantly associated with prevalent asthma.
journal_name
Neuropeptidesjournal_title
Neuropeptidesauthors
Lu Y,Andiappan AK,Lee B,Ho R,Lim TK,Kuan WS,Goh DY,Mahadevan M,Sim TB,Wang Y,Van Bever HP,Rotzschke O,Larbi A,Ng TPdoi
10.1016/j.npep.2016.07.003subject
Has Abstractpub_date
2016-10-01 00:00:00pages
117-121eissn
0143-4179issn
1532-2785pii
S0143-4179(16)30017-8journal_volume
59pub_type
杂志文章相关文献
NEUROPEPTIDES文献大全abstract：:Neuropeptide Y (NPY) potentiates noradrenaline (NA)-evoked constriction of circular segments of the rabbit femoral artery. The potentiation occurs exclusively in the lower concentration-range of the agonist NA (10(-8)-3 x 10(-7) M) without any change in maximum contractile effect. NPY per se is without contractile eff...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(91)90068-t
更新日期：1991-05-01 00:00:00
abstract：:Cocaine- and amphetamine-regulated transcript (CART) peptides have a wide CNS distribution and appear to play an important role in a number of physiological processes including reward and reinforcement, feeding, locomotion, stress responses and perception of pain. We have further investigated the expression of CART pe...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/j.npep.2007.11.001
更新日期：2008-02-01 00:00:00
abstract：:Plasma levels of ghrelin, an orexigenic peptide, are increased during conditions of chronic starvation, such as in patients with anorexia nervosa. However, it is not known whether such increase can be related to the number of preproghrelin mRNA-expressing cells in the stomach, and if chronic starvation may activate a ...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/j.npep.2015.04.003
更新日期：2015-06-01 00:00:00
abstract：:The effect of opioid peptide, D-alanine2-leucine-enkephalin and opioid homolog peptide, des-tyrosine-methionine-enkephalin in concentrations of 1 x 10(-6) and 1 x 10(-5) M was investigated on the action potential parameters of frog sciatic nerve. Des-tyrosine-methionine-enkephalin was used as the control to prove the ...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/j.npep.2004.03.003
更新日期：2004-04-01 00:00:00
abstract：:The antinociceptive effect of intrathecally (i.t.) administered protease inhibitors was tested against capsaicin (800 ng) injected into the dorsal surface of a hindpaw. Both p-hydroxymercuribenzoate (2-8 nmol), a cysteine protease inhibitor, and phosphoramidon (1-4 nmol), an endopeptidase 24.11 inhibitor in the presen...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/s0143-4179(98)90064-6
更新日期：1998-10-01 00:00:00
abstract：:[3H]-Dynorphin A (1-8) was degraded in brain homogenates at 25 degrees and even at 0 degree C. The peptidase inhibitors bestatin and captopril almost completely protected[3H]-dynorphin A (1-8) from degradation at 0 degree C but had only little effect on binding at this temperature. At 25 degrees C, the binding of [3H]...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(85)90072-1
更新日期：1985-02-01 00:00:00
abstract：:In our previous study we have identified PACAP, VIP and their receptors in rat malignant peripheral nerve sheath tumor (MPNST) cells, thus showing anti-apoptotic roles. Recently it has been shown that the tumor suppressor neurofibromin, encoded by the Neurofibromatosis type I (NF1) gene, promotes MPNST cells sensitivi...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/j.npep.2009.10.003
更新日期：2010-02-01 00:00:00
abstract：:Pheochromocytoma (PC-12) cells exposed to nerve growth factor (NGF) acquire a sympathetic neuron-like phenotype. This NGF-response is blocked by methylation inhibitors and can be mimicked by the farnesylated methylated small GTP-binding protein p21ras. The implicated involvement of prenylation, methylation and a small...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(93)90036-a
更新日期：1993-01-01 00:00:00
abstract：:Neuropeptide Y (NPY) is known to bind to at least two types of receptors (Y1 & Y2). One type (Y2) is able to bind and undergo activation by both NPY and its C-terminal fragments with good potency while the other (Y1) requires the full length of NPY for good potency. For most NPY analogs that have been examined, potenc...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(90)90073-8
更新日期：1990-11-01 00:00:00
abstract：:Several studies suggest that prenatal ethanol exposure (PEE) facilitates ethanol intake. Opioid peptides play a main role in ethanol reinforcement during infancy and adulthood. However, PEE effects upon motor responsiveness elicited by an ethanol challenge and the participation of opioids in these actions remain to be...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/j.npep.2016.11.006
更新日期：2017-04-01 00:00:00
abstract：:In vivo microdialysis was employed to explore the effects of different selective non-peptides NK(1),NK(2) and NK(3) receptor antagonists on the corticotropin releasing factor (CRF)-induced release of acetylcholine (ACh) in the hippocampus of rats and guinea-pigs. In both species, the intracerebroventricular (i.c.v.) a...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/s0143-4179(03)00019-2
更新日期：2003-04-01 00:00:00
abstract：:Hippocampal neurogenesis is important for modulating the behavioural responses to stress and for certain forms of learning and memory. The mechanisms underlying the necessary coupling of neuronal activity to neural stem/progenitor cell (NSPC) function remain poorly understood. Within the dentate subgranular stem cell ...
journal_title：Neuropeptides
pub_type： 杂志文章,评审
doi：10.1016/j.npep.2013.10.002
更新日期：2013-12-01 00:00:00
abstract：:The intracerebrally administered dynorphin-B produced not only an antinociceptive response but a motor dysfunction such as "barrel-rolling", circling, jumping or ataxia in mice. These two effects were observed in a same dose range. Both responses were also produced by a nonopioid fragment, des-Tyr-dynorphin-B. Bestati...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(89)90082-6
更新日期：1989-05-01 00:00:00
abstract：:The biological and immunological properties of insulin-like material produced by brain cells from 12 day old mice, cultured in serum-free media were examined. Differences were seen in the rate of appearance, relative amounts and behaviour on HPLC between immunoreactive and biologically active insulin-like material. Ex...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(87)90006-0
更新日期：1987-05-01 00:00:00
abstract：:Using field potential recording in the CA1 region of hippocampal slices from rats injected with cysteamine (200 mg/kg, s.c.), changes in activity and plasticity of Schaffer collateral-CA1 pyramidal cell synapses were examined. Extracellular field potential recording prior to and following either theta-pattern primed b...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/s0143-4179(02)00029-x
更新日期：2002-08-01 00:00:00
abstract：:Tachykinins are a family of pronociceptive neuropeptides with a specific role in pain and inflammation. Several mechanisms regulate endogenous tachykinins and Substance P (SP) levels, including the differential expression of protachykinin mRNA and the controlled secretion of tachykinins from neurons. Proteolysis is su...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/j.npep.2016.06.002
更新日期：2016-10-01 00:00:00
abstract：:Abnormal aggregation of beta-amyloid (Aβ) peptide into amyloid plaques in the brain has been identified as one of the key factors in instigating AD pathogenesis. Inhibition of Aβ aggregation can be an important therapeutic strategy in disease management. In this work, we demonstrate the application of structure-based ...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/j.npep.2020.102030
更新日期：2020-06-01 00:00:00
abstract：:In order to study the morphological localization of the endogenous benzodiazepine ligand octadecaneuropeptide (ODN) in rat brain, we have developed antibodies against this peptide. Using a radioimmunoassay for ODN, we have observed that synthetic ODN and serial dilutions of several brain areas gave parallel displaceme...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(90)90155-r
更新日期：1990-01-01 00:00:00
abstract：:6-Beta-fluoro-6-desoxy-oxymorphone (FOXY) is a fluorinated derivative of oxymorphone originally developed as a potential PET scanning ligand. Preliminary work (Rothman et al., Neuropeptides 4: 311-317, 1984) demonstrated that [3H]FOXY selectively labeled mu opioid binding sites with low levels of nonspecific binding. ...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(88)90020-0
更新日期：1988-01-01 00:00:00
abstract：:Pituitary adenylate cyclase activating peptide and vasoactive intestinal peptide belong to the same neuropeptide family. Both peptides are present in nerve fibers in the gastric wall and are thought to be involved in the regulation of inflammatory processes. Experimental ulcers were induced in the rat gastric mucosa b...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/s0143-4179(98)90081-6
更新日期：1998-12-01 00:00:00
abstract：:In critical patients, sepsis-induced muscle wasting is considered to be an important contributor to complications and mortality. Previous work mainly focuses on the peripheral molecular mechanism of muscle degradation, however little evidence exists for the role of central nervous system in the process. In the present...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/j.npep.2014.10.002
更新日期：2014-12-01 00:00:00
abstract：:Oxytocic peptides extracted from the brain and plasma of the brushtail possum, Trichosurus vulpecula, were separated by reverse-phase high pressure lipid chromatography (HPLC) and quantified by specific radioimmunoassays for oxytocin (OT) and mesotocin (MT). The pituitary, hypothalamus and cerebral cortex were found t...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(90)90123-g
更新日期：1990-07-01 00:00:00
abstract：:Oxytocin, intraperitoneally injected to 26-month-old male rats 60 min before testing, significantly improved social memory (at doses of 3 and 6 ng/kg) and reduced the duration of immobility in the behavioral despair test (at doses of 50 and 500 micrograms/kg). These results are in agreement with previous data obtained...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(95)90021-7
更新日期：1995-09-01 00:00:00
abstract：:3H-Bradykinin binding sites with the characteristics of receptors were identified in homogenates of bovine hippocampus and PC-12 cells. The characteristics of the binding were similar in both types of tissue and paralleled those of the B2 bradykinin receptor. Following exposure to nerve growth factor for 72 hours, the...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(88)90056-x
更新日期：1988-11-01 00:00:00
abstract：:Neural stem cells (NSC) could promote the repair after spinal cord transection (SCT), the underlying mechanism, however, still keeps to be defined. This study reported that NSC grafts significantly improved sensory and locomotor functions in adult rats with SCT in acute stage after injury. NSC could survive; different...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/j.npep.2012.06.001
更新日期：2013-02-01 00:00:00
abstract：:The progesterone metabolite, allopregnanolone (AlloP), is a GABAA receptor modulating steroid and is known to have orexigenic and pro-obesity effects. The neurobiological mechanisms underpinning these effects are most likely due to enhanced GABAergic signaling in the lateral arcuate nucleus (ARC) and medial paraventri...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/j.npep.2019.101937
更新日期：2019-08-01 00:00:00
abstract：:Galanin and the N-terminal fragment Galanin(1-15) are involved in central cardiovascular regulation. The present paper reviews the recent cardiovascular results obtained by intracisternal injections of Galanin and Galanin(1-15) showing that: (A) the Galanin antagonist M40 blocks the central cardiovascular responses in...
journal_title：Neuropeptides
pub_type： 杂志文章,评审
doi：10.1016/j.npep.2004.12.009
更新日期：2005-06-01 00:00:00
abstract：:The anatomical distribution of Substance P (SP) has been investigated since the development of antibodies against it in the 1970s. Although initial studies were performed with antibodies that also recognised the other endogenous neurokinins, most of the initial descriptions are surprisingly still valid today. In this ...
journal_title：Neuropeptides
pub_type： 杂志文章,评审
doi：10.1054/npep.2000.0834
更新日期：2000-10-01 00:00:00
abstract：:Orexins are neuropeptides that are localized to neurons in the lateral and dorsal hypothalamus but its receptors are distributed to many different regions of the central nervous system. Orexins are implicated in a variety of physiological functions including sleep regulation, energy homeostats, and stress reactions. F...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/j.npep.2016.12.007
更新日期：2017-02-01 00:00:00
abstract：:Endomorphins are newly discovered mu-opioid receptor selective immunocompetent opioid peptides. Endomorphin 1 is predominantly distributed in brain, while endomorphin 2 is widely allocated in the spinal cord. Lately, endomorphins have been investigated as modulators of reactive oxygen and nitrogen species. Nitric oxid...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/j.npep.2009.11.004
更新日期：2010-02-01 00:00:00
