beta-Endorphin in neuroblastoma x glioma hybrid cells.

abstract：:Morphine (M) produced a dose-related decrease in metabolic weight loss (MWL) over a three-hour period, despite the fact that it significantly enhanced locomotor activity in male mice. This conservation of energy was specific to opioid receptors because naltrexone HCl (N) blocked it. These receptors were localized main...

journal_title：Neuropeptides

authors： Henry LJ,Walker J,Margules DL

更新日期：1985-02-01 00:00:00

abstract：:Down syndrome is the most common genetic disorder associated with mental retardation. Subjects and mice models for Down syndrome (such as Ts65Dn) show defects in the formation of neuronal networks in both the hippocampus and the cerebral cortex. The principal neurons display alterations in the morphology, density and ...

journal_title：Neuropeptides

authors： Hernández S,Gilabert-Juan J,Blasco-Ibáñez JM,Crespo C,Nácher J,Varea E

更新日期：2012-02-01 00:00:00

abstract：:The anatomical distribution of Substance P (SP) has been investigated since the development of antibodies against it in the 1970s. Although initial studies were performed with antibodies that also recognised the other endogenous neurokinins, most of the initial descriptions are surprisingly still valid today. In this ...

journal_title：Neuropeptides

authors： Ribeiro-da-Silva A,Hökfelt T

更新日期：2000-10-01 00:00:00

abstract：:Enkephalin-immunoreactive neurons have been identified in the central nervous system of the fruit fly Drosophila melanogaster by immunocytochemical techniques. Analyses of fly extracts by high performance liquid chromatography and radioimmunoassay show a relatively complex pattern of immunoreactive compounds. The most...

journal_title：Neuropeptides

authors： Pagés M,Jiménez F,Ferrús A,Peralta E,Ramírez G,Gelpí E

更新日期：1983-12-01 00:00:00

abstract：:The effects of vasoactive intestinal peptide (VIP) on spatial cognitive deficits induced in the rat by injections of scopolamine were examined in a radial arm maze. A single intraperitoneal (i.p.), subcutaneous (s.c.) or intracerebroventricular (i.c.v.) injection of VIP inhibited the reduction in the number of initial...

journal_title：Neuropeptides

authors： Yamaguchi Y,Kobayashi H

更新日期：1994-03-01 00:00:00

abstract：:Our previous studies showed the modulation of cocaine and amphetamine regulated transcript (CART) positive neurons and CART mRNA by adrenalectomy and corticosterone replacement in hypothalamic nuclei of male rat brain. More recently, we have shown by CART immunohistochemistry that restraint and forced swim (FS) stress...

journal_title：Neuropeptides

authors： Balkan B,Gozen O,Yararbas G,Koylu EO,Akinturk S,Kuhar MJ,Pogun S

更新日期：2006-06-01 00:00:00

abstract：:Orexins/hypocretins are neuropeptides that have various physiological effects, including the regulation of feeding behavior, neuroendocrine functions and sleep-wake cycles. Recent studies have suggested that the orexin system may also be involved in brain ischemic reactions. It is also known that changes in sleep patt...

journal_title：Neuropeptides

authors： Dohi K,Nishino S,Nakamachi T,Ohtaki H,Morikawa K,Takeda T,Shioda S,Aruga T

更新日期：2006-08-01 00:00:00

abstract：:The present study was undertaken in order to establish the possible involvement of melatonin in the mechanisms underlying the arginine-vasopressin (AVP) responses to physical exercise and angiotensin II (ANG II). On two mornings at least 1 week apart, normal male subjects were tested with exercise on a bicycle ergomet...

journal_title：Neuropeptides

authors： Chiodera P,Volpi R,Capretti L,Giuliani N,Maffei ML,Coiro V

更新日期：1998-04-01 00:00:00

abstract：:The orexins (hypocretins) are lateral hypothalamic (LH) neuropeptides that have been implicated in a variety of behaviors ranging from feeding to sleep and arousal. Evidence from animal models suggests a role for orexins in reward processing and drug addiction. In the present study, we investigated the direct effect o...

journal_title：Neuropeptides

authors： Zarepour L,Fatahi Z,Sarihi A,Haghparast A

更新日期：2014-06-01 00:00:00

abstract：:Cocaine-regulated and amphetamine-regulated transcript (CART) is a neuropeptide with reported neuroprotective effects in ischemic cerebral injury. However, its mechanism has not yet been elucidated. Herein, we investigated the role and mechanism of CART in synaptic plasticity in neurons after ischemic cerebral stroke....

journal_title：Neuropeptides

authors： Zhang Z,Cao X,Bao X,Zhang Y,Xu Y,Sha D

更新日期：2020-06-01 00:00:00

abstract：:Various studies have shown a relationship between nerves and bones. Recent evidence suggests that both sensory and sympathetic nerves affect bone metabolism; however, little is known about how neuropeptides are involved in the differentiation of pluripotent stem cells into osteoblastic (OB) cells. To evaluate the puta...

journal_title：Neuropeptides

authors： Nagao S,Goto T,Kataoka S,Toyono T,Joujima T,Egusa H,Yatani H,Kobayashi S,Maki K

更新日期：2014-12-01 00:00:00

abstract：:We examined the effects of gestational cocaine treatment on oxytocin levels in the whole hippocampus (HIP), ventral tegmental area (VTA), medial preoptic area (MPOA) and amygdala (AMY) in rat dams on postpartum days (PPDs) 1 and 2. Cocaine treatment significantly reduced oxytocin levels in the MPOA within 12-16 h of d...

journal_title：Neuropeptides

authors： Johns JM,Lubin DA,Walker CH,Meter KE,Mason GA

更新日期：1997-10-01 00:00:00

abstract：:Glucocorticoid deficiency is associated with a decrease of food intake. Orexigenic peptides, neuropeptide Y (NPY) and agouti related protein (AgRP), and the anorexigenic peptide proopiomelanocortin (POMC), expressed in the arcuate nucleus of the hypothalamus (ARC), are regulated by meal-induced signals. Orexigenic neu...

journal_title：Neuropeptides

authors： Uchoa ET,Silva LE,de Castro M,Antunes-Rodrigues J,Elias LL

更新日期：2012-06-01 00:00:00

abstract：:D-Arg containing dipeptides, H-Tyr-D-Arg-OMe and H-Tyr (Et)-D-Arg-OMe, and D-Arg2 substituted N-terminal tetrapeptides of dermorphin, H-Tyr-D-Arg-Phe-Gly-OEt and H-Tyr (Et)-D-Arg-Phe-Gly-OEt administered intracerebroventricularly exhibited dose-dependent antinociceptive activities in mice as measured by the tail press...

journal_title：Neuropeptides

authors： Sato T,Sakurada S,Sakurada T,Furuta S,Nakata N,Kisara K,Sasaki Y,Suzuki K

更新日期：1984-06-01 00:00:00

abstract：:The role of somatostatin and a stable analogue, sandostatin (Octreotide), on the responses of spinal cord neurones in vivo was investigated in the rat. Electrical C-fibre stimulation was used as a model of acute nociception and the response to subcutaneous formalin was used as a model of longer term events. Intratheca...

journal_title：Neuropeptides

authors： Chapman V,Dickenson AH

更新日期：1992-11-01 00:00:00

abstract：:Recent studies have shown that oxytocin reduces food intake and body weight gain and promotes lipolysis in some species, including humans. Interestingly, these effects of oxytocin are more marked in obese individuals. Although the menopausal loss of ovarian function induces increased visceral adiposity and some metabo...

journal_title：Neuropeptides

authors： Iwasa T,Matsuzaki T,Mayila Y,Yanagihara R,Yamamoto Y,Kawakita T,Kuwahara A,Irahara M

更新日期：2019-06-01 00:00:00

abstract：:Recently, we demonstrated that brain neuropeptide Y (NPY) mRNA expression was increased in heat exposed chicks. However, the functions of brain NPY during heat stress are unknown. This study was conducted to investigate whether centrally administered NPY affects food intake, rectal temperature, monoamines, stress horm...

journal_title：Neuropeptides

authors： Bahry MA,Chowdhury VS,Yang H,Tran PV,Do PH,Han G,Ikeda H,Cockrem JF,Furuse M

更新日期：2017-04-01 00:00:00

abstract：:The progesterone metabolite, allopregnanolone (AlloP), is a GABAA receptor modulating steroid and is known to have orexigenic and pro-obesity effects. The neurobiological mechanisms underpinning these effects are most likely due to enhanced GABAergic signaling in the lateral arcuate nucleus (ARC) and medial paraventri...

journal_title：Neuropeptides

authors： Löfgren M,Holmberg E,Bäckström T,Egecioglu E,Dickson SL

更新日期：2019-08-01 00:00:00

abstract：:Acid extracts of cat adrenal medullae were found to contain neurotensin-like (0.71 +/- 0.21nmol/gm), met-enkephalin-like (11.71 +/- 2.87nmol/gm), leu-enkephalin-like (1.95 +/- 0.11nmol/gm) and somatostatin-like (1.57 +/- 0.63pmol/gm) immunoreactivities. Using isolated retrogradely perfused cat adrenal glands the secre...

journal_title：Neuropeptides

authors： Corder R,Mason DF,Perrett D,Lowry PJ,Clement-Jones V,Linton EA,Besser GM,Rees LH

更新日期：1982-10-01 00:00:00

abstract：:We have developed an extraction method and radioimmunoassay for the measurement of interleukin-1 beta (IL-1 beta) in rat tissues, using an antibody specific for IL-1 beta, IL-1 beta was detected in the spleen and thymus of control rats. Adrenalectomy (ADX) had no effect upon control levels of IL-1 beta. In animals wit...

journal_title：Neuropeptides

authors： Jessop DS,Chowdrey HS,Lightman SL

更新日期：1993-06-01 00:00:00

abstract：:The effects of stimulation and blockade of neurotensin receptors on striatal acetylcholine release were examined in anaesthetized rats using microdialysis. Local perfusion with neurotensin (100 nM) did not influence the release of acetylcholine. Application of neurotensin (100 nM) 30 min after haloperidol (125 microgr...

journal_title：Neuropeptides

authors： Steinberg R,Rodier D,Mons G,Gully D,Le Fur G,Soubrié P

更新日期：1995-07-01 00:00:00

abstract：:The action of corticotropin-releasing factor (CRF) is mediated by two recently identified receptors, CRFR1 and CRFR2, that differ with respect to their anatomical distribution and pharmacologic ligand-binding properties. Here we show by an analysis of circadian heartbeat interval fluctuations that CRFR2-deficiency in ...

journal_title：Neuropeptides

authors： Stiedl O,Meyer M

更新日期：2003-02-01 00:00:00

abstract：:Melanin-concentrating hormone (MCH) and dynorphin genes are expressed in two discrete neuron populations of the rat lateral hypothalamus. Their roles remain hypothetical in mammals. In order to analyse changes in MCH and dynorphin gene expression, a multiplex competitive semi-quantitative reverse transcription-polymer...

journal_title：Neuropeptides

authors： Hervé C,Fellmann D

更新日期：1997-06-01 00:00:00

abstract：:Using the latency for tail-flick after thermal stimulation we have assessed the effects of alpha-, gamma(1)- and gamma(2)-MSH on nociceptive threshold in the mice. Intracisternal injections of gamma(2)-MSH induced a distinct analgesia, while gamma(1)-MSH in the same doses gave only a minor analgesia. Intracisternal al...

journal_title：Neuropeptides

authors： Klusa V,Germane S,Svirskis S,Opmane B,Wikberg JE

更新日期：2001-02-01 00:00:00

abstract：:Dynorphin 1-8 (DYN 1-8) and Dynorphin B (DYN B) have been immunocytochemically localized to neuronal perikarya throughout the adult rat central nervous system (CNS). In order to determine if any DYN 1-8 and DYN B immunoreactive (DYN-I) cell bodies have long projections, indirect immunofluorescence was used in combinat...

journal_title：Neuropeptides

authors： Code RA,Fallon JH

更新日期：1986-08-01 00:00:00

abstract：:In vitro structure-activity studies with cholecystokinin (CCK)/gastrin-related peptides, including C- and N-terminal fragments of CCK 26-33, were undertaken in guinea pig gallbladder and ileum. The general order of potency in both smooth muscle preparations is CCK 26-33 greater than CCK 1-33 greater than 27-33 much mu...

journal_title：Neuropeptides

authors： Gaudreau P,St-Pierre S,Pert CB,Quirion R

更新日期：1987-07-01 00:00:00

abstract：:This study found that dynorphin had a biphasic concentration response relationship on N-methyl-D-aspartate (NMDA) receptor-mediated currents in the CA3 region of the guinea pig hippocampal slice. A previous study demonstrated that the inhibitory effect was mediated by a kappa 2 opioid receptor. In the present study, t...

journal_title：Neuropeptides

authors： Caudle RM,Dubner R

更新日期：1998-02-01 00:00:00

abstract：:The effects of several mu and kappa opioid receptor agonists on urinary excretion were examined in the water-loaded rat. Mu agonists induced anti-diuresis whereas kappa agonists caused diuresis. Furthermore, high efficacy kappa agonists eg. U50, 488H and tifluadom, produced marked diuretic effects, whereas kappa parti...

journal_title：Neuropeptides

authors： Skingle M,Hayes AG,Tyers MB

更新日期：1985-02-01 00:00:00

abstract：:Pyroglutamyl peptidase I activity from soluble and membrane-bound fractions of rat brain homogenates is inhibited by the presence of sodium deoxycholate but not by triton X-100. Biobeads SM2, a polystyrene adsorbent reported to be useful in removing detergents from aqueous solutions, inhibits enzymatic activity in bot...

journal_title：Neuropeptides

authors： Alba F,Arenas JC,Lopez MA

更新日期：1995-08-01 00:00:00

abstract：OBJECTIVES:Postmenopausal osteoporosis (PMO) is a metabolic skeletal disorder with impaired bone density and bone quality in postmenopausal women. The aim of the present study was to investigate the correlation between neuropeptides, bone microstructure and pain threshold in ovariectomized (OVX) rats. METHODS:Female r...

journal_title：Neuropeptides

authors： Xie W,Li F,Han Y,Li Z,Xiao J

更新日期：2020-06-01 00:00:00