Abstract:
:The effects of graded amounts of centrally injected [intracerebroventricular, i.c.v.] oxytocin [OXT] have been studied on the steady-state level and pargyline-induced accumulation of serotonin [5-HT] in the hypothalamus, mesencephalon and dorsal hippocampus of rats. OXT only weakly affected the steady-state level of 5-HT. The pargyline-induced accumulation, on the other hand, was inhibited by central OXT treatment. Whereas OXT inhibited 5-HT accumulation in a dose-dependent manner in the hypothalamus, only the lowest amount of OXT was effective in the mesencephalon and the dorsal hippocampus. The data raise the possibility that an altered 5-HT metabolism is likely to have functional significance in the endocrine and behavioral effects of OXT.
journal_name
Neuropeptidesjournal_title
Neuropeptidesauthors
Schwarzberg H,Kovács GL,Telegdy Gdoi
10.1016/0143-4179(84)90125-2subject
Has Abstractpub_date
1984-03-01 00:00:00pages
145-56issue
2eissn
0143-4179issn
1532-2785pii
0143-4179(84)90125-2journal_volume
4pub_type
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