Abstract：
:Procolipase is secreted as a protein consisting of 101 amino acids. In the intestinal lumen, procolipase is activated by trypsin and cleaves to form the active colipase and the pentapeptide from the amino terminus. This pentapeptide is called enterostatin. Pancreatic procolipase synthesis is stimulated by a high-fat diet. A large body of evidence has been gathered in the past decade demonstrating the role of enterostatin in the inhibition of food intake; in particular, fat intake. This aspect of enterostatin will be discussed in this review. Other functions of enterostatin such as the inhibition of insulin secretion, will not. Apolipoprotein AIV is a protein synthesized by the human intestine. Similar to procolipase, the synthesis and secretion of apo AIV are also stimulated by fat absorption. In 1992, Fujimoto et al. first demonstrated that apo AIV is a satiety signal secreted by the small intestine following the ingestion of a lipid meal. Subsequently, this initial observation was followed by a number of studies supporting apo AIV's role in the inhibition of food intake. This review will discuss the role of apo AIV in inhibiting food intake.
journal_name
Neuropeptidesjournal_title
Neuropeptidesauthors
Liu M,Shen L,Tso Pdoi
10.1054/npep.1999.0052keywords:
subject
Has Abstractpub_date
1999-10-01 00:00:00pages
425-33issue
5eissn
0143-4179issn
1532-2785pii
S0143-4179(99)90052-5journal_volume
33pub_type
杂志文章,评审相关文献
NEUROPEPTIDES文献大全abstract：:A series of analogues of substance P, where the Met11 residue was replaced by Glu(OCH2CH3), Glu(OBzl) and Hse(CH3), were synthesized in order to investigate the effect on agonist activity of modifications at the C-terminal residue. The biological activities in the guinea-pig ileum assay (NK1 receptor) and rat [text sa...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(94)90013-2
更新日期：1994-07-01 00:00:00
abstract：:Immunoreactive substance P (SPI) and somatostatin (SOMI) are found in spinal cord but their physiological roles remain speculative. Several classes of neuropeptides, including endogenous opioids and thyrotropin-releasing hormone (TRH), have been implicated in the pathogenesis or recovery from spinal cord injury. In th...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(85)90092-7
更新日期：1985-06-01 00:00:00
abstract：:Information on the physiological functions of neuropeptide FF; NPFF, a morphine modulating octapeptide in avians is lacking. Thus, we designed a study to investigate the effects of central NPFF with particular emphasis on appetite-related processes. Cobb-500 chicks were intracerebroventricularly (ICV) injected with 0,...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/j.npep.2007.08.003
更新日期：2007-12-01 00:00:00
abstract：:Spermidine is a naturally occurring endogenous polyamine synthesized from diamine putrescine. It is a well-known autophagy inducer that maintains cellular and neuronal homeostasis. Healthy brain development and function are dependent on brain polyamine concentration. Polyamines interact with the opioid system, glutama...
journal_title：Neuropeptides
pub_type： 杂志文章,评审
doi：10.1016/j.npep.2020.102083
更新日期：2020-10-01 00:00:00
abstract：:Rat/mouse hemokinin-1 (r/m HK-1) has been identified as a member of the tachykinin family and its effect in colonic contractile activity remains unknown. We investigated the effects and mechanisms of actions of r/m HK-1 on the mouse colonic contractile activity in vitro by comparing it with that of substance P (SP). R...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/j.npep.2009.03.004
更新日期：2009-06-01 00:00:00
abstract：:The orally active, α-hemoglobin derived hemopressin (PVNFKFLSH, Hp(1-9)) and its truncated (PVNFKFL, Hp(1-7) and PVNFKF, Hp(1-6)) and extended ((R)VDPVNFKFLSH, VD-Hp(1-9) and RVD-Hp(1-9)) derivatives have been postulated to be the endogenous peptide ligands of the cannabinoid receptor type 1 (CB1). In an attempt to cr...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/j.npep.2016.02.001
更新日期：2016-08-01 00:00:00
abstract：:Levels of beta-endorphin immunoreactive material (IRM) in cerebrospinal fluid (CSF) have been reported to correlate inversely with postoperative morphine requirement. Considering proopiomelanocortin (POMC) derivatives as predictors for sensitivity to postoperative pain, we determined authentic beta-endorphin (beta-end...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/j.npep.2005.10.001
更新日期：2006-02-01 00:00:00
abstract：:In rat preprogalanin, galanin is C-terminally flanked by a 60 amino acid long peptide: galanin message-associated peptide (GMAP). GMAP sequences in different species show high degree of homology, suggesting a biological role. However, the study of the physiological and pharmacological actions of this peptide have been...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/s0143-4179(98)90037-3
更新日期：1998-04-01 00:00:00
abstract：:We have evaluated the peripheral blood natural killer (NK) cell activity and the in vitro effect of recombinant gamma-interferon (r gamma-IFN) on NK cell activity in 23 patients with a neuroendocrine tumour of the pancreas, small intestine or liver, and 23 healthy controls. Patients with a gastrinoma showed a NK cell ...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(91)90033-f
更新日期：1991-09-01 00:00:00
abstract：:The tetra-peptide FMRF-NH(2) is a cardioexcitatory peptide in the clam. Using the antibody against this peptide, FMRF-NH(2)-like immunoreactive material was detected in mammalian CNS. Subsequently, mammalian FMRF-NH(2) immunoreactive peptides were isolated from bovine brain and characterized to be FLFQPQRF-NH(2) (NPFF...
journal_title：Neuropeptides
pub_type： 杂志文章,评审
doi：10.1016/j.npep.2007.06.004
更新日期：2008-02-01 00:00:00
abstract：:Neuropeptide Y (NPY) is involved in multiple processes such as behavior, energy and bone metabolism. Previous studies have relied on global NPY depletion to examine its effects on bone. However, this approach is unable to distinguish the central or local source of NPY influencing bone. Our aim was to identify which ce...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/j.npep.2018.11.009
更新日期：2019-02-01 00:00:00
abstract：:Obesity is a global public health problem. Orexin and endocannabinoid signaling in the hypothalamus have been shown to regulate feeding and are promising molecular targets for obesity treatment. In this study, we attempted to analyze effects of orexin-A and endocannabinoid signaling modulation in the arcuate nucleus (...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/j.npep.2018.04.001
更新日期：2018-06-01 00:00:00
abstract：:The role of somatostatin on inhibition of both normal and tumor cell cycle, secretion of endocrine and exocrine cells, as well as induction apoptosis is well documented. However, its effect on T cell development and thymic structure is not fully clarified. In order to investigate the influence of somatostatin in vivo ...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/j.npep.2007.06.003
更新日期：2007-12-01 00:00:00
abstract：:We have described the binding of [125I]endothelin-1 (ET-1) to cultured rat cerebellar granule cells. Binding of [125I]ET-1 was specific, saturable, and time-dependent. Scatchard analysis of saturation binding data indicated a single class of high affinity binding site with a KD of 95 pM, and a Bmax of 8110 receptors/c...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(91)90005-4
更新日期：1991-02-01 00:00:00
abstract：:Neuropeptide Y (NPY) is known to bind to at least two types of receptors (Y1 & Y2). One type (Y2) is able to bind and undergo activation by both NPY and its C-terminal fragments with good potency while the other (Y1) requires the full length of NPY for good potency. For most NPY analogs that have been examined, potenc...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(90)90073-8
更新日期：1990-11-01 00:00:00
abstract：:Superfusion of the dorsal surface of the septum with artificial cerebrospinal fluid containing 10(-10) M [Arg8]-vasopressin (VP) significantly increased the negative (N) wave in field potentials (FPs) elicited in the lateral septum (LS) of rats by stimulation of the fimbria-fornix. A similar increase in the FPs negati...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(86)90078-8
更新日期：1986-01-01 00:00:00
abstract：:Plasma levels of ghrelin, an orexigenic peptide, are increased during conditions of chronic starvation, such as in patients with anorexia nervosa. However, it is not known whether such increase can be related to the number of preproghrelin mRNA-expressing cells in the stomach, and if chronic starvation may activate a ...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/j.npep.2015.04.003
更新日期：2015-06-01 00:00:00
abstract：:We have previously shown that the kappa-opioid agonist, asimadoline, produces time-dependent changes in neuropeptide concentrations in the joints of rats with chronic arthritis. We hypothesized that asimadoline acts on peripheral terminals to modulate substance P (SP) release. To address this hypothesis, here we have ...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1054/npep.2000.0813
更新日期：2000-06-01 00:00:00
abstract：:DPDPE ([D-Pen2, D-Pen5]-Enkephalin) and DPLPE ([D-Pen2, L-Pen5]-Enkephalin) are conformationally-constrained cyclic analogs of enkephalin with high selectivity for delta opioid receptors. Intracerebroventricular (i.c.v.) administration of each analog acutely produces a complex EEG response in rats characterized by a d...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(84)90065-9
更新日期：1984-12-01 00:00:00
abstract：:The distribution and modification of the tachykinins Substance P (SP) and neurokinin A (NKA), their precursor beta-preprotachykinins (beta-PPT) and the receptors involved in their activity, NK-1 and NK-2, were studied in trinitrobenzensulphonic acid (TNB) colitis. Rats were intrarectally treated with a 120 mg/ml of TN...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/j.npep.2008.07.001
更新日期：2008-10-01 00:00:00
abstract：:The present study is designed to elucidate the involvement of neuronal mechanisms in corticotropin-releasing factor (CRF)-induced anti-oedema effects. Oedema was induced in the rat hind paw by subcutaneous injection of 3 nmol of serotonin (5-HT). A single dose of CRF (9.4, 37.5 or 75 pmol) was given either ipsilateral...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1054/npep.2000.0800
更新日期：2000-04-01 00:00:00
abstract：:There is now unequivocal evidence that the angiotensin-converting enzyme 2(ACE2)-Ang-(1-7)-Mas axis is a key component of the renin-angiotensin system (RAS) cascade, which is closely correlated with ischemic insult occurrence. Our previous studies demonstrated that the Ang-(1-7), was an active member of the brain RAS....
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/j.npep.2013.09.002
更新日期：2013-10-01 00:00:00
abstract：:AtT-20 cells are known to synthesize two molecular weight forms of the prohormone converting enzyme PC1 with molecular masses of 87 and 66 kDa. In this study we have analyzed basal and stimulated secretion of these proteins. Western blot results show that basal secretion medium of cultured AtT-20 cells contained low c...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(93)90096-s
更新日期：1993-08-01 00:00:00
abstract：:Glucagon-like peptide-1 (7-36)-amide (GLP-1) is a gut peptide, which exerts significant effects on glucose homeostasis. GLP-1 and GLP-1 receptors are also widely distributed in the central nervous system. In the present study, we aimed to investigate the effects of intracerebroventricularly (i.c.v.)-injected GLP-1 on ...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/j.npep.2010.02.002
更新日期：2010-08-01 00:00:00
abstract：:The Third Galanin Symposium presented many different and exciting results on galanin research reflecting a major progress since the previous symposium in 1998. A major impression was the many possible relationships of galaninergic mechanisms to important brain functions such as development, cognition and ageing as wel...
journal_title：Neuropeptides
pub_type：
doi：10.1016/j.npep.2005.03.002
更新日期：2005-06-01 00:00:00
abstract：:Fracture repair is a complex yet well orchestrated regenerative process involving numerous signaling and cell types including osteoblasts. Here we showed that NPY, a neurotransmitter with regulatory functions in bone homeostasis, may contribute to the post-fracture bone healing in patients with traumatic brain injury-...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/j.npep.2016.09.005
更新日期：2016-12-01 00:00:00
abstract：:The effects of a potent serine protease inhibitor, Boc-D-Phe-Pro-Arg-H, on the secretion and content of ACTH and beta-endorphin-like immunoreactivities of cultured rat anterior pituitary cells were studied. Basal release of the hormones was not affected by the drug but secretion in response to stalk-median eminence ex...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(82)90066-x
更新日期：1982-10-01 00:00:00
abstract：:We have assessed the influence of acute bilateral nephrectomy, of captopril and saralasin, on the hypotensive activity of neurotensin (NT) and of various hypotensive drugs in pentobarbital-anesthetized rats. The results show that the hypotensive activity of NT and of compound 48/80 (C48/80), in contrast to that of his...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(83)90047-1
更新日期：1983-04-01 00:00:00
abstract：:PTHrP and its receptor PTHR1 are found in the CNS and peripheral nervous system. The presence of PTHrP mRNA has been detected in the superior cervical ganglion (SCG), but there are no data on the cellular distribution of PTHrP and PTHR1 in the SCG. Although it is known that ovarian activity and reproductive status inf...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/j.npep.2014.09.005
更新日期：2014-12-01 00:00:00
abstract：:Neurokinin A (NKA) and substance P (SP) are often co-localized in small sensory neurons and have been suggested to subserve similar roles. We have now compared tissue levels of NKA and SP in rat cervical dorsal root ganglia with those in the central and peripheral terminations of the same neurons. We found that NKA co...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(95)90027-6
更新日期：1995-04-01 00:00:00
