Abstract：
:Exercise at different intensities is able to induce different physical and psychological statuses of the subjects. The β-endorphin (β-EP) in central nervous system is thought to play an important role in physical exercise. However, its expression patterns and physiological effects in the central nuclei under different exercise states are not well understood. Five-week old male Sprague-Dawley rats were randomly divided into two groups of 21 each: Control and Exercise. Control rats were sedentary while Exercise rats were arranged to run on a treadmill (5-week adapting or moderate exercise and 2-week high-intensity exercise). Seven rats were taken from each group at day33, day42 and day49 for examination of blood biochemical parameters (lactate, Lac; blood urea nitrogen, BUN; glucose) and for detection of nuclei β-EP level with immunohistochemistry. The results showed that Lac and BUN levels were significant increased after the high intensity exercise. The five-week exercise caused a significantly increased β-EP in caudate putamen (CPu), amygdala, paraventricular thalamic nucleus (PVT), ventromedial hypothalamus nucleus (VMH) and gigantocellular reticular nucleus (Gi). The high intensity exercise induced an elevated β-EP in CPu and nucleus of the solitary tract (Sol), but a decreased β-EP in globus pallidus (GP). Compared with Control, exercise rats showed an elevated β-EP in CPu, PVT, VMH, accumbens nucleus, Gi and Sol, and a decreased β-EP in GP at day49. The β-EP levels in acurate nucleus, periadueductal gray and parabrachial nucleus were not changed at day33, 42 and 49. In conclusion, β-EP levels in different nuclei changed under the moderate and high intensity exercises, which may contribute to modifying exercise-produced psychological and physiological effects.
journal_name
Neuropeptidesjournal_title
Neuropeptidesauthors
Xue L,Sun J,Zhu J,Ding Y,Chen S,Ding M,Pei Hdoi
10.1016/j.npep.2020.102048subject
Has Abstractpub_date
2020-08-01 00:00:00pages
102048eissn
0143-4179issn
1532-2785pii
S0143-4179(20)30059-7journal_volume
82pub_type
杂志文章相关文献
NEUROPEPTIDES文献大全abstract：:HPLC techniques were used to identify peptides that possess vasopressin-like immunoreactivity in the chicken neurohypophysis. The presence of arginine vasotocin (AVT) was confirmed together with arginine vasopressin (AVP). That the presence of AVP may be confined to the chicken, and not other avian species, was conclu...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(86)90045-4
更新日期：1986-08-01 00:00:00
abstract：:We examined whether the cholinergic mechanism is involved in the paradoxical GH responses to vasoactive intestinal peptide (VIP) and peptide histidine methionine (PHM) in acromegaly. 28 patients with active acromegaly underwent i.v. bolus injections of thyrotropin-releasing hormone (TRH, 500 micrograms), GH-releasing ...
journal_title：Neuropeptides
pub_type： 临床试验,杂志文章
doi：10.1016/0143-4179(94)90047-7
更新日期：1994-08-01 00:00:00
abstract：:Neuropeptide Y (NPY) has been implicated in anxiolytic- and antidepressant-like behaviour as well as seizure-suppressant effects in rodents. Although these effects appear to be predominantly mediated via other NPY receptors (Y1 and/or Y2), several studies have also indicated a role for Y5 receptors. Gene therapy using...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/j.npep.2012.01.002
更新日期：2012-04-01 00:00:00
abstract：:The hypocretins/orexins (hcrts) are two recently described neuropeptides derived from the same precursor and expressed in a few thousand neurons in the perifornical area of the lateral hypothalamus, which project throughout the brain. The hypocretins bind to two G-protein coupled receptors with different selective aff...
journal_title：Neuropeptides
pub_type： 杂志文章,评审
doi：10.1054/npep.2002.0892
更新日期：2002-04-01 00:00:00
abstract：:The neurokinin-1 (NK-1) receptor interacts with peptides that belong to the tachykinin family. NK-1 is inducible in bone marrow (BM) stroma. In neural cells, its expression is high to constitutive. Screening of three cDNA libraries indicated that this different in NK-1 expression in neural and BM cells could not be ex...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1054/npep.2002.0869
更新日期：2002-02-01 00:00:00
abstract：:Pituitary adenylate cyclase activating peptide and vasoactive intestinal peptide belong to the same neuropeptide family. Both peptides are present in nerve fibers in the gastric wall and are thought to be involved in the regulation of inflammatory processes. Experimental ulcers were induced in the rat gastric mucosa b...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/s0143-4179(98)90081-6
更新日期：1998-12-01 00:00:00
abstract：:In situ hybridisation histochemistry was used to study the effect of intra-peritoneal reserpine administration on messenger RNA (mRNA) levels in the locus coeruleus (LC) of the rat. 48h after injection, levels of mRNA encoding tyrosine hydroxylase (TH) and neuropeptide Y (NPY) in the LC increased to approximately 250%...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(91)90105-r
更新日期：1991-03-01 00:00:00
abstract：:We have recently documented the expression of preprothyrotropin-releasing hormone (TRH) gene in murine, human and rat testis. Moreover, we have localized TRH to rat Leydig cells immunohistochemically, and found that both prepro TRH mRNA and TRH levels are developmentally regulated in the rat testis. To investigate the...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(94)90070-1
更新日期：1994-09-01 00:00:00
abstract：:In this study guinea pig, rat and bovine striatal extracts have been shown to contain putative opioid peptide precursors in the molecular weight (Mr) range 2000-greater than 70000. The material eluting greater than 70 kDalton contained bioassayable opioid activity but not Met- or Leu-enkephalin-like immunoreactivities...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(85)90069-1
更新日期：1985-02-01 00:00:00
abstract：:We have used immunohistochemistry and in situ hybridization histochemistry to visualize CGRP and the mRNA encoding the CGRP precursor in the stomach. CGRP is present in nerve fibers in the mucosa. CGRP mRNA and CGRP itself are also found in non-neural cells in the lamina propria. These cells are likely to be macrophag...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(93)90030-e
更新日期：1993-02-01 00:00:00
abstract：:Pyroglutamyl diazomethyl ketone and N-benzyloxycarbonyl prolyl prolinal, specific inhibitors of pyroglutamyl peptidase I and prolyl endopeptidase respectively, were used to study the possible role of these enzymes in the regulation of thyrotropin releasing hormone turnover. In vitro thyrotropin releasing hormone relea...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(87)90010-2
更新日期：1987-05-01 00:00:00
abstract：:Dynorphin 1-8 (DYN 1-8) and Dynorphin B (DYN B) have been immunocytochemically localized to neuronal perikarya throughout the adult rat central nervous system (CNS). In order to determine if any DYN 1-8 and DYN B immunoreactive (DYN-I) cell bodies have long projections, indirect immunofluorescence was used in combinat...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(86)90043-0
更新日期：1986-08-01 00:00:00
abstract：:Oxytocin, either intraperitoneally injected (200 ng/rat) or intracerebroventricularly infused (1 ng/rat in 4 microliters saline) 60 and 15 min respectively before testing, significantly increased the lordosis response to the mounting male of ovariectomized, estrogen/progesterone treated rats. The intracerebroventricul...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(85)90095-2
更新日期：1985-06-01 00:00:00
abstract：:Morphine (M) produced a dose-related decrease in metabolic weight loss (MWL) over a three-hour period, despite the fact that it significantly enhanced locomotor activity in male mice. This conservation of energy was specific to opioid receptors because naltrexone HCl (N) blocked it. These receptors were localized main...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(85)90019-8
更新日期：1985-02-01 00:00:00
abstract：:Development of transgenic mice overexpressing GH and GHR-KO mice with GH resistance provided novel animal models for study of the somatotropic axis and for identifying GH actions that may be relevant to its current and contemplated use in medicine and agriculture. Studies of phenotypic characteristics of these animals...
journal_title：Neuropeptides
pub_type： 杂志文章,评审
doi：10.1054/npep.2002.0889
更新日期：2002-04-01 00:00:00
abstract：:Nerve growth factor (NGF) was reported to be increased in the serum and skin of atopic dermatitis (AD) patients, to the extent that serum nerve growth factor levels were proposed to serve as a marker of disease severity. We studied NGF levels in the serum and dermis using skin microdialysis and attempted to correlate ...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/j.npep.2011.07.008
更新日期：2011-12-01 00:00:00
abstract：:Procolipase is secreted as a protein consisting of 101 amino acids. In the intestinal lumen, procolipase is activated by trypsin and cleaves to form the active colipase and the pentapeptide from the amino terminus. This pentapeptide is called enterostatin. Pancreatic procolipase synthesis is stimulated by a high-fat d...
journal_title：Neuropeptides
pub_type： 杂志文章,评审
doi：10.1054/npep.1999.0052
更新日期：1999-10-01 00:00:00
abstract：:Nociceptin/Orphanin FQ (N/OFQ) is a 17-amino acid peptide that binds to the nociceptin receptor (NOP). N/OFQ and NOP receptors are expressed in numerous brain areas. The generation of specific agonists, antagonists and receptor-deficient mice or rats has enabled progress in elucidating the biological functions of N/OF...
journal_title：Neuropeptides
pub_type： 杂志文章,评审
doi：10.1016/j.npep.2015.03.005
更新日期：2015-04-01 00:00:00
abstract：:The discriminative stimulus properties of the selective CCKB-receptor antagonist, L-365,260 were evaluated in rats trained to discriminate diazepam (2 mg/kg) or morphine (5 mg/kg) from vehicle, using a two-lever food reinforced technique. In the diazepam drug discrimination, the benzodiazepine-receptor agonist FG8205 ...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(94)90119-8
更新日期：1994-05-01 00:00:00
abstract：:We examined gene expression of corticotropin-releasing hormone and neuropeptide Y level in the hypothalamic paraventricular nucleus of mouse bearing a human oral squamous cell carcinoma. A cell line derived from a human oral squamous cell carcinoma was inoculated into the lower dorsal area of nude mice. Body weight, t...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/j.npep.2004.07.004
更新日期：2004-12-01 00:00:00
abstract：:Superfusion of the dorsal surface of the septum with artificial cerebrospinal fluid containing 10(-10) M [Arg8]-vasopressin (VP) significantly increased the negative (N) wave in field potentials (FPs) elicited in the lateral septum (LS) of rats by stimulation of the fimbria-fornix. A similar increase in the FPs negati...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(86)90078-8
更新日期：1986-01-01 00:00:00
abstract：:Brain extracts from 3 to 4 day old final (eighth) instar larvae of Opisina arenosella (Lepidoptera) stimulate amylase release from midgut preparations maintained in vitro. This effect of the brain extract was both time and dose dependent. The brain factor stimulating enzyme release may be a peptide as it is heat stabl...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/s0143-4179(03)00025-8
更新日期：2003-06-01 00:00:00
abstract：:The effects of forskolin or phorbol-13-myristate (PMA) injected intrathecally (i.t.) or intracerebroventricularly (i.c.v.) on the inhibition of the tail-flick and hotplate responses induced by morphine or beta-endorphin administered i.c.v. were studied. Animals pretreated with forskolin (20 micrograms) i.t. for 10 min...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/s0143-4179(96)90085-2
更新日期：1996-04-01 00:00:00
abstract：:The level of opioid peptides in several brain areas and in the pituitary was estimated in WAG/Rij rats, which are considered to be a genetic animal model for human absence epilepsy. In comparison with three groups of non-epileptic controls, these epileptic rats had an elevated level of the proenkephalin-derived peptid...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(92)90037-w
更新日期：1992-03-01 00:00:00
abstract：:In the present study, electrophysiological recordings were made from hippocampal slices obtained from mice overexpressing galanin under the promoter for the platelet-derived growth factor-B (GalOE mice). In these mice, a particularly strong galanin expression is seen in the granule cell layer/mossy fibers. Paired-puls...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/j.npep.2005.02.005
更新日期：2005-06-01 00:00:00
abstract：:The distribution of beta-endorphin (1-27) immunoreactive cell bodies and fibres was studied in the diencephalon of the cat using an indirect immunoperoxidase technique. In the thalamus, almost all the immunoreactive fibres were found in the midline region and in nuclei located near the midline, whereas in the hypothal...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/s0143-4179(96)90072-4
更新日期：1996-06-01 00:00:00
abstract：:Intravenous injections of neurotensin (NT) (0.5, 1 and 2 nmoles kg-1) evoked dose-dependent increases in histaminemia and hematocrit, and marked hypotensive effect, in anesthetized rats. The increase of plasma histamine was rapid in onset (within sec), peak plasma histamine being reached in less than 2 min. The declin...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(82)90010-5
更新日期：1982-12-01 00:00:00
abstract：:3H-Bradykinin binding sites with the characteristics of receptors were identified in homogenates of bovine hippocampus and PC-12 cells. The characteristics of the binding were similar in both types of tissue and paralleled those of the B2 bradykinin receptor. Following exposure to nerve growth factor for 72 hours, the...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(88)90056-x
更新日期：1988-11-01 00:00:00
abstract：:Lysine-vasopressin (LVP) at different concentrations (2 ng, 200 pg) was injected into the lateral ventricle and cisterna magna. The effect on hypothalamic self-stimulation was studied in rats. LVP (2 ng) decreased the self-stimulation rate after intracerebroventricular and cisternal application. Injection of 200 pg LV...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/s0143-4179(87)90119-3
更新日期：1987-11-01 00:00:00
abstract：:The relative roles of hypothalamic corticotropin-releasing-hormone (CRH) and vasopressin (AVP) as mediators of the stimulant effect of vasoactive intestinal peptide (VIP) and peptide histidine isoleucine (PHI) on ACTH and corticosterone (CORT) secretion, were examined using receptor blockade of endogenous CRH and AVP....
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(95)90112-4
更新日期：1995-03-01 00:00:00
