The effect of pituitary adenylate cyclase-activating polypeptide on elevated plus maze behavior and hypothermia induced by morphine withdrawal.

Abstract:

:The aim of the present investigation was to study the effects of pituitary adenylate cyclase-activating polypeptide (PACAP) on morphine withdrawal-induced behavioral changes and hypothermia in male CFLP mice. Elevated plus maze (EPM) and jump tests were used to assess naloxone-precipitated morphine withdrawal-induced behavior responses. Different doses of subcutaneous (s.c.) naloxone, (0.1 and 0.2 mg/kg, respectively) were used to precipitate the emotional and psychical aspects of withdrawal on EPM and 1 mg/kg (s.c.) was used to induce the somatic withdrawal signs such as jumping, and the changes in body temperature. In our EPM studies, naloxone proved to be anxiolytic in mice treated with morphine. Chronic intracerebroventricular (i.c.v.) administration of PACAP alone had no significant effect on withdrawal-induced anxiolysis and total activity at doses of 500 ng and 1 μg. At dose of 500 ng, however, PACAP significantly counteracted the reduced motor activity in the EPM test in mice treated with morphine and diminished the hypothermia and shortened jump latency induced by naloxone in mice treated with morphine. These findings indicate that anxiolytic-like behavior may be mediated via a PACAP-involved pathway and PACAP may play an important role in chronic morphine withdrawal-induced hypothermia as well.

journal_name

Neuropeptides

journal_title

Neuropeptides

authors

Lipták N,Dochnal R,Babits A,Csabafi K,Szakács J,Tóth G,Szabó G

doi

10.1016/j.npep.2011.12.001

subject

Has Abstract

pub_date

2012-02-01 00:00:00

pages

11-7

issue

1

eissn

0143-4179

issn

1532-2785

pii

S0143-4179(11)00104-1

journal_volume

46

pub_type

杂志文章
  • Neurokinin A and substance P vary independently in different regions of rat sensory neurons.

    abstract::Neurokinin A (NKA) and substance P (SP) are often co-localized in small sensory neurons and have been suggested to subserve similar roles. We have now compared tissue levels of NKA and SP in rat cervical dorsal root ganglia with those in the central and peripheral terminations of the same neurons. We found that NKA co...

    journal_title:Neuropeptides

    pub_type: 杂志文章

    doi:10.1016/0143-4179(95)90027-6

    authors: Bakhle YS,Bell C

    更新日期:1995-04-01 00:00:00

  • The analgesic effect of orexin-A in a murine model of chemotherapy-induced neuropathic pain.

    abstract::Orexins are neuropeptides that are localized to neurons in the lateral and dorsal hypothalamus but its receptors are distributed to many different regions of the central nervous system. Orexins are implicated in a variety of physiological functions including sleep regulation, energy homeostats, and stress reactions. F...

    journal_title:Neuropeptides

    pub_type: 杂志文章

    doi:10.1016/j.npep.2016.12.007

    authors: Toyama S,Shimoyama N,Shimoyama M

    更新日期:2017-02-01 00:00:00

  • Comparison of soluble and membrane-bound pyroglutamyl peptidase I activities in rat brain tissues in the presence of detergents.

    abstract::Pyroglutamyl peptidase I activity from soluble and membrane-bound fractions of rat brain homogenates is inhibited by the presence of sodium deoxycholate but not by triton X-100. Biobeads SM2, a polystyrene adsorbent reported to be useful in removing detergents from aqueous solutions, inhibits enzymatic activity in bot...

    journal_title:Neuropeptides

    pub_type: 杂志文章

    doi:10.1016/0143-4179(95)90092-6

    authors: Alba F,Arenas JC,Lopez MA

    更新日期:1995-08-01 00:00:00

  • Plasma chromogranin A after severe burn trauma.

    abstract:BACKGROUND:Chromogranin A (CgA) in plasma (P-CgA), a neuroendocrine marker of sympathetic stress, has been shown to predict mortality in medical intensive care. We hypothesized that the magnitude of CgA release would reflect stress load, and thereby injury severity in burn intensive care patients. METHODS:Fifty-one co...

    journal_title:Neuropeptides

    pub_type: 杂志文章

    doi:10.1016/j.npep.2012.10.004

    authors: Lindahl AE,Low A,Stridsberg M,Sjöberg F,Ekselius L,Gerdin B

    更新日期:2013-06-01 00:00:00

  • Neuropeptide Y immunoreactivity and corticotropin-releasing hormone mRNA level are increased in the hypothalamus of mouse bearing a human oral squamous cell carcinoma.

    abstract::We examined gene expression of corticotropin-releasing hormone and neuropeptide Y level in the hypothalamic paraventricular nucleus of mouse bearing a human oral squamous cell carcinoma. A cell line derived from a human oral squamous cell carcinoma was inoculated into the lower dorsal area of nude mice. Body weight, t...

    journal_title:Neuropeptides

    pub_type: 杂志文章

    doi:10.1016/j.npep.2004.07.004

    authors: Lee JH,Cha MJ,Choi SH,Hwang SJ,Kim DG,Jahng JW

    更新日期:2004-12-01 00:00:00

  • Blockage of spinal endothelin A receptors attenuates bone cancer pain via regulation of the Akt/ERK signaling pathway in mice.

    abstract::Bone cancer pain (BCP) is a common source of pain in patients with advanced stage and metastatic cancer; however, existing treatment for this kind of pain remains deficient. Being closely related to sensory change and inflammatory pain in both the central and peripheral nervous systems, endothelin A receptor (ETAR) pl...

    journal_title:Neuropeptides

    pub_type: 杂志文章

    doi:10.1016/j.npep.2018.01.003

    authors: Han MM,Yang CW,Cheung CW,Li J

    更新日期:2018-04-01 00:00:00

  • Anxiolytic-like effects after vector-mediated overexpression of neuropeptide Y in the amygdala and hippocampus of mice.

    abstract::Neuropeptide Y (NPY) causes anxiolytic- and antidepressant-like effects after central administration in rodents. These effects could theoretically be utilized in future gene therapy for anxiety and depression using viral vectors for induction of overexpression of NPY in specific brain regions. Using a recombinant aden...

    journal_title:Neuropeptides

    pub_type: 杂志文章

    doi:10.1016/j.npep.2014.09.004

    authors: Christiansen SH,Olesen MV,Gøtzsche CR,Woldbye DP

    更新日期:2014-12-01 00:00:00

  • The role of nociceptin and dynorphin in chronic pain: implications of neuro-glial interaction.

    abstract::Nociceptin-opioid peptide (NOP) receptor, also known as opioid receptor like-1 (ORL1), was identified following the cloning of the kappa-opioid peptide (KOP) receptor, and the characterization of these receptors revealed high homology. The endogenous ligand of NOP, nociceptin (NOC), which shares high homology to dynor...

    journal_title:Neuropeptides

    pub_type: 杂志文章,评审

    doi:10.1016/j.npep.2011.03.002

    authors: Mika J,Obara I,Przewlocka B

    更新日期:2011-08-01 00:00:00

  • Hormonal effects of high dose naloxone in humans.

    abstract::Utilizing a double-blind crossover design, the hormonal effects of high dose, 2 mg/kg, were compared to low dose, 0.4 mg (approx. 5 micrograms/kg), naloxone administration in physically healthy humans. A significant naloxone dose effect on plasma cortisol levels was found (p less than 0.001), but no significant effect...

    journal_title:Neuropeptides

    pub_type: 临床试验,杂志文章

    doi:10.1016/0143-4179(85)90010-1

    authors: Cohen MR,Cohen RM,Pickar D,Kreger D,McLellan C,Murphy DL

    更新日期:1985-07-01 00:00:00

  • The interaction of brain insulin receptors with wheat germ agglutinin.

    abstract::Brain insulin receptors adsorb to and are recoverable from wheat germ agglutinin-agarose (WGA) columns. Similar results are obtained using dissuccinimidyl suberate (DSS)-crosslinked receptors or photo-affinity labeled receptors. WGA can be used for partial purification of brain insulin receptors provided the appropria...

    journal_title:Neuropeptides

    pub_type: 杂志文章

    doi:10.1016/0143-4179(87)90025-4

    authors: Shemer J,LeRoith D

    更新日期:1987-01-01 00:00:00

  • Changes in substance P and somatostatin in the spinal cord after traumatic spinal injury in the rat.

    abstract::Immunoreactive substance P (SPI) and somatostatin (SOMI) are found in spinal cord but their physiological roles remain speculative. Several classes of neuropeptides, including endogenous opioids and thyrotropin-releasing hormone (TRH), have been implicated in the pathogenesis or recovery from spinal cord injury. In th...

    journal_title:Neuropeptides

    pub_type: 杂志文章

    doi:10.1016/0143-4179(85)90092-7

    authors: Faden AI,Jacobs TP,Helke CJ

    更新日期:1985-06-01 00:00:00

  • Cocaine- and amphetamine-regulated transcript protects synaptic structures in neurons after ischemic cerebral injury.

    abstract::Cocaine-regulated and amphetamine-regulated transcript (CART) is a neuropeptide with reported neuroprotective effects in ischemic cerebral injury. However, its mechanism has not yet been elucidated. Herein, we investigated the role and mechanism of CART in synaptic plasticity in neurons after ischemic cerebral stroke....

    journal_title:Neuropeptides

    pub_type: 杂志文章

    doi:10.1016/j.npep.2020.102023

    authors: Zhang Z,Cao X,Bao X,Zhang Y,Xu Y,Sha D

    更新日期:2020-06-01 00:00:00

  • Molecular characterization and peptide specificity of two vasoactive intestinal peptide (VIP) binding sites in the chicken pineal.

    abstract::Here we report that chicken pineal membranes express high affinity receptors for Vasoactive Intestinal Peptide (VIP), as revealed by competitive displacement analysis of [3-iodotyrosyl-125I]-VIP by native VIP. These binding sites were further characterized by covalent cross-linking of radioiodinated VIP to chicken pin...

    journal_title:Neuropeptides

    pub_type: 杂志文章

    doi:10.1016/0143-4179(91)90066-r

    authors: Meunier AC,Voisin P,Van Camp G,Cenatiempo Y,Muller JM

    更新日期:1991-05-01 00:00:00

  • The evidence of thyroliberin/triiodothyronine control of TSH secretory response from human peripheral blood monocytes cultured in vitro.

    abstract::Immune system function has been shown to be under the influence of various neuromodulators and endocrine system peptides. This in vitro study describes the stimulatory effect of thyrotropin releasing hormone (thyroliberin, TRH) on thyrotropin (TSH) release from cultured human peripheral blood monocytes. The stimulator...

    journal_title:Neuropeptides

    pub_type: 杂志文章

    doi:10.1016/0143-4179(93)90065-i

    authors: Komorowski J,Stepień H,Pawlikowski M

    更新日期:1993-07-01 00:00:00

  • BDNF expression with functional improvement in transected spinal cord treated with neural stem cells in adult rats.

    abstract::Neural stem cells (NSC) could promote the repair after spinal cord transection (SCT), the underlying mechanism, however, still keeps to be defined. This study reported that NSC grafts significantly improved sensory and locomotor functions in adult rats with SCT in acute stage after injury. NSC could survive; different...

    journal_title:Neuropeptides

    pub_type: 杂志文章

    doi:10.1016/j.npep.2012.06.001

    authors: He BL,Ba YC,Wang XY,Liu SJ,Liu GD,Ou S,Gu YL,Pan XH,Wang TH

    更新日期:2013-02-01 00:00:00

  • Behavioural characteristics of the Prader-Willi syndrome related biallelic Snord116 mouse model.

    abstract::Prader-Willi syndrome (PWS) is the predominant genetic cause of obesity in humans and is associated with several behavioural phenotypes such as altered motoric function, reduced activity, and learning disabilities. It can include mood instability and, in some cases, psychotic episodes. Recently, the Snord116 gene has ...

    journal_title:Neuropeptides

    pub_type: 杂志文章

    doi:10.1016/j.npep.2015.06.009

    authors: Zieba J,Low JK,Purtell L,Qi Y,Campbell L,Herzog H,Karl T

    更新日期:2015-10-01 00:00:00

  • Oxytocin selectively increases ERalpha mRNA in the neonatal hypothalamus and hippocampus of female prairie voles.

    abstract::During neonatal development exogenous oxytocin increases ERalpha immunoreactivity in the hypothalamus of female prairie voles. The purpose of this study was to determine if the increase in ERalpha is associated with an increase in ERalpha mRNA expression and to determine if the effect is specific to ER subtype or if o...

    journal_title:Neuropeptides

    pub_type: 杂志文章

    doi:10.1016/j.npep.2006.10.002

    authors: Pournajafi-Nazarloo H,Carr MS,Papademeteriou E,Schmidt JV,Cushing BS

    更新日期:2007-02-01 00:00:00

  • The cloned vasopressin V1a receptor stimulates phospholipase A2, phospholipase C, and phospholipase D through activation of receptor-operated calcium channels.

    abstract::Arginine vasopressin mediates its effects through vasopressin receptor activation and second messenger production. Recent cloning of the V1a receptor provided the opportunity to investigate the possible signal transduction pathways associated with this single vasopressin receptor subtype. When stably expressed in CHO ...

    journal_title:Neuropeptides

    pub_type: 杂志文章

    doi:10.1016/0143-4179(94)90017-5

    authors: Briley EM,Lolait SJ,Axelrod J,Felder CC

    更新日期:1994-07-01 00:00:00

  • Cellular localization of somatostatin mRNA in rat retina.

    abstract::In an attempt to determine the localization of the messenger RNA (mRNA) encoding somatostatin in the rat retina, we studied Sprague-Dawley rats by in situ hybridization histochemistry using radiolabelled oligodeoxyribonucleotides complementary for rat somatostatin mRNA. Among the layers of retina, we found specific la...

    journal_title:Neuropeptides

    pub_type: 杂志文章

    doi:10.1016/0143-4179(90)90135-l

    authors: Yamaguchi K,Gaur VP,Spira AW,Turner JE

    更新日期:1990-09-01 00:00:00

  • Humanin ameliorates diazepam-induced memory deficit in mice.

    abstract::Humanin (HN) is an endogenous 24-residue peptide. A highly potent HN derivative, S14G-HN, which has a substitution of serine 14 to glycine, reduced amyloid burden and suppressed cognitive impairment in a mouse model of Alzheimer's disease. S14G-HN also suppressed amnesia induced by a muscarinic receptor antagonist in ...

    journal_title:Neuropeptides

    pub_type: 杂志文章

    doi:10.1016/j.npep.2016.10.008

    authors: Murakami M,Nagahama M,Maruyama T,Niikura T

    更新日期:2017-04-01 00:00:00

  • Opposite effects of opiate agonists on metabolic weight loss in mice.

    abstract::Morphine (M) produced a dose-related decrease in metabolic weight loss (MWL) over a three-hour period, despite the fact that it significantly enhanced locomotor activity in male mice. This conservation of energy was specific to opioid receptors because naltrexone HCl (N) blocked it. These receptors were localized main...

    journal_title:Neuropeptides

    pub_type: 杂志文章

    doi:10.1016/0143-4179(85)90019-8

    authors: Henry LJ,Walker J,Margules DL

    更新日期:1985-02-01 00:00:00

  • Differential effects of forskolin and phorbol-13-myristate injected intrathecally or intracerebroventricularly on antinociception induced by morphine or beta-endorphin administered intracerebroventricularly in the mouse.

    abstract::The effects of forskolin or phorbol-13-myristate (PMA) injected intrathecally (i.t.) or intracerebroventricularly (i.c.v.) on the inhibition of the tail-flick and hotplate responses induced by morphine or beta-endorphin administered i.c.v. were studied. Animals pretreated with forskolin (20 micrograms) i.t. for 10 min...

    journal_title:Neuropeptides

    pub_type: 杂志文章

    doi:10.1016/s0143-4179(96)90085-2

    authors: Suh HW,Song DK,Sim YB,Chung KM,Kim YH

    更新日期:1996-04-01 00:00:00

  • Is oxytocin-induced grooming mediated by uterine-like receptors?

    abstract::In this study, we examined whether the mechanisms mediating the induction of grooming behavior by oxytocin (OT) is similar to mechanisms mediating the effects of OT on uterine contractility. Sprague-Dawley strain female rats were injected intracerebroventricularly (ICV) with OT or OT analogues and then were observed f...

    journal_title:Neuropeptides

    pub_type: 杂志文章

    doi:10.1016/0143-4179(86)90068-5

    authors: Caldwell JD,Hruby VJ,Hill P,Prange AJ Jr,Pedersen CA

    更新日期:1986-07-01 00:00:00

  • Expression of neuropeptide receptor mRNA during osteoblastic differentiation of mouse iPS cells.

    abstract::Various studies have shown a relationship between nerves and bones. Recent evidence suggests that both sensory and sympathetic nerves affect bone metabolism; however, little is known about how neuropeptides are involved in the differentiation of pluripotent stem cells into osteoblastic (OB) cells. To evaluate the puta...

    journal_title:Neuropeptides

    pub_type: 杂志文章

    doi:10.1016/j.npep.2014.10.004

    authors: Nagao S,Goto T,Kataoka S,Toyono T,Joujima T,Egusa H,Yatani H,Kobayashi S,Maki K

    更新日期:2014-12-01 00:00:00

  • Cocaine treatment alters oxytocin receptor binding but not mRNA production in postpartum rat dams.

    abstract::Gestational cocaine treatment in rat dams results in decreased oxytocin (OT) levels, up-regulated oxytocin receptor (OTR) binding density and decreased receptor affinity in the whole amygdala, all concomitant with a significant increase in maternal aggression on postpartum day six. Rat dams with no gestational drug tr...

    journal_title:Neuropeptides

    pub_type: 杂志文章

    doi:10.1016/j.npep.2006.03.002

    authors: Jarrett TM,McMurray MS,Walker CH,Johns JM

    更新日期:2006-06-01 00:00:00

  • Cardiac dynamics in corticotropin-releasing factor receptor subtype-2 deficient mice.

    abstract::The action of corticotropin-releasing factor (CRF) is mediated by two recently identified receptors, CRFR1 and CRFR2, that differ with respect to their anatomical distribution and pharmacologic ligand-binding properties. Here we show by an analysis of circadian heartbeat interval fluctuations that CRFR2-deficiency in ...

    journal_title:Neuropeptides

    pub_type: 杂志文章

    doi:10.1016/s0143-4179(02)00135-x

    authors: Stiedl O,Meyer M

    更新日期:2003-02-01 00:00:00

  • Distribution of neuromedin U binding sites in the rat CNS revealed by in vitro receptor autoradiography.

    abstract::Neuromedin U (NMU), a neuropeptide implicated in feeding, inflammation, pain control and anxiety-related behaviours, is widely distributed in peripheral organs and the CNS. These effects are thought to be mediated by its receptors NMU(1) and NMU(2). Since its precise sites of interaction in the CNS were to date unknow...

    journal_title:Neuropeptides

    pub_type: 杂志文章

    doi:10.1016/j.npep.2008.04.008

    authors: Mangold C,Ksiazek I,Yun SW,Berger E,Binkert C

    更新日期:2008-08-01 00:00:00

  • Actions of endothelin and corticotropin releasing factor in the guinea-pig ileum: no evidence for an interaction with capsaicin-sensitive neurons.

    abstract::Both endothelins and corticotropin releasing factor (CRF) appear in capsaicin-sensitive neurons. We have investigated the effects of human endothelin-1 (ET-1) and CRF in the guinea-pig ileum longitudinal and circular preparations and sought for ways of specific antagonism. With the aid of tachyphylaxis to capsaicin (i...

    journal_title:Neuropeptides

    pub_type: 杂志文章

    doi:10.1016/s0143-4179(03)00048-9

    authors: Lázár Z,Benkó R,Bölcskei K,Rumbus Z,Wolf M,Holzer P,Maggi CA,Barthó L

    更新日期:2003-08-01 00:00:00

  • Chronic pain in the rat: selective alterations in CNS and pituitary pools of dynorphin as compared to vasopressin.

    abstract::Inoculation of rats at the tail-base with Mycobacterium led to arthritic swelling and inflammation of all four limbs. Immunoreactive (ir)-dynorphin (DYN) increased in anterior but not neurointermediate pituitary. In the brain, only thalamus showed a rise and, in spinal cord, a large elevation was seen. Ir-vasopressin ...

    journal_title:Neuropeptides

    pub_type: 杂志文章

    doi:10.1016/0143-4179(85)90044-7

    authors: Millan MJ,Millan MH,Pilcher CW,Colpaert FC,Herz A

    更新日期:1985-02-01 00:00:00

  • The induction and potentiation of c-Jun and c-Fos expression in spinal neurons mediated by NK1 and NK2 receptors.

    abstract::Specific antagonists were used to determine NK1 and NK2 receptor mediation of the expression of c-Jun and c-Fos inducible transcription factors. (ITFs) in dorsal horn neurons. The induction of c-Jun by C-fiber stimulation was strongly reduced in the superficial laminae by NK1 and NK2 antagonists, but only weakly in th...

    journal_title:Neuropeptides

    pub_type: 杂志文章

    doi:10.1054/npep.1999.0005

    authors: Redburn JL,Leah JD

    更新日期:1999-04-01 00:00:00