Abstract:
:The intracerebrally administered dynorphin-B produced not only an antinociceptive response but a motor dysfunction such as "barrel-rolling", circling, jumping or ataxia in mice. These two effects were observed in a same dose range. Both responses were also produced by a nonopioid fragment, des-Tyr-dynorphin-B. Bestatin, an aminopeptidase inhibitor, markedly potentiated the antinociceptive response induced by dynorphin-B but not the motor dysfunction. Bestatin did not affect the responses produced by des-Tyr-dynorphin-B. In the presence of bestatin, low doses of dynorphin-B produced an antinociceptive response without the motor dysfunction. Naloxone antagonized the potentiated antinocicpetion but had no effect on the motor dysfunction. These results suggest that dynorphin-B produced an analgesia through opioid receptors and that this peptide also induced a motor dysfunction through a nonopioid receptor.
journal_name
Neuropeptidesjournal_title
Neuropeptidesauthors
Nakazawa T,Ikeda M,Kaneko T,Yamatsu K,Kitagawa K,Kiso Ydoi
10.1016/0143-4179(89)90082-6subject
Has Abstractpub_date
1989-05-01 00:00:00pages
277-83issue
4eissn
0143-4179issn
1532-2785pii
0143-4179(89)90082-6journal_volume
13pub_type
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