Identification of 3H-bradykinin binding sites in PC-12 cells and brain.

abstract：:Opiates have been shown to affect prolactin secretion directly at the pituitary level. However, opiate binding sites have not been characterized on anterior pituitary tissue. In the present work we show that a soluble factor present in anterior pituitary membrane preparation inhibit opiate binding on striatal membrane...

journal_title：Neuropeptides

authors： Rotten D,Leblanc P,Kordon C,Weiner RI,Enjalbert A

更新日期：1986-11-01 00:00:00

abstract：:Injection of endothelin-1 (9 pmol) into the lateral cerebral ventricle of rats produced barrel-rotations, convulsions, tonic hindlimb extensions, facial clonus, and kinetic ataxia for up to 45 min. Quantitative metabolic autoradiographs produced from the [14C]deoxyglucose method and analyzed over 60 individual brain s...

journal_title：Neuropeptides

authors： Gross PM,Wainman DS,Espinosa FJ,Nag S,Weaver DF

更新日期：1992-04-01 00:00:00

abstract：:Cerebral amyloid-beta protein (Abeta) deposition and associated neuroinflammation and apoptosis are increasingly recognized as an important component leading to cognitive impairment in Alzheimer's disease (AD). Humanin (HN) and its derivative, S14G-HN (HNG), are best known for their ability to suppress neuronal death ...

journal_title：Neuropeptides

authors： Miao J,Zhang W,Yin R,Liu R,Su C,Lei G,Li Z

更新日期：2008-10-01 00:00:00

abstract：:In equilibrium binding studies, using 3H-etorphine and 3H-diprenorphine, digitonin extracts of frog brain membranes are found to contain two classes of sites, one of which is seen only in the presence of Na+ ions. Centrifugation of the extracts in sucrose gradients separates two macromolecular components (10S and 12S)...

journal_title：Neuropeptides

authors： Puget A,Frances B,Jauzac P,Meunier JC

更新日期：1984-12-01 00:00:00

abstract：:We have used immunohistochemistry and in situ hybridization histochemistry to visualize CGRP and the mRNA encoding the CGRP precursor in the stomach. CGRP is present in nerve fibers in the mucosa. CGRP mRNA and CGRP itself are also found in non-neural cells in the lamina propria. These cells are likely to be macrophag...

journal_title：Neuropeptides

authors： Jakab G,Webster HD,Salamon I,Mezey E

更新日期：1993-02-01 00:00:00

abstract：:Cocaine- and amphetamine-regulated transcript (CART) peptides have a wide CNS distribution and appear to play an important role in a number of physiological processes including reward and reinforcement, feeding, locomotion, stress responses and perception of pain. We have further investigated the expression of CART pe...

journal_title：Neuropeptides

authors： Press DA,Wall MJ

更新日期：2008-02-01 00:00:00

abstract：:PTHrP and its receptor PTHR1 are found in the CNS and peripheral nervous system. The presence of PTHrP mRNA has been detected in the superior cervical ganglion (SCG), but there are no data on the cellular distribution of PTHrP and PTHR1 in the SCG. Although it is known that ovarian activity and reproductive status inf...

journal_title：Neuropeptides

authors： Filipović N,Vrdoljak M,Vuica A,Jerić M,Jeličić Kadić A,Utrobičić T,Mašek T,Grković I

更新日期：2014-12-01 00:00:00

abstract：:Spermidine is a naturally occurring endogenous polyamine synthesized from diamine putrescine. It is a well-known autophagy inducer that maintains cellular and neuronal homeostasis. Healthy brain development and function are dependent on brain polyamine concentration. Polyamines interact with the opioid system, glutama...

journal_title：Neuropeptides

authors： Ghosh I,Sankhe R,Mudgal J,Arora D,Nampoothiri M

更新日期：2020-10-01 00:00:00

abstract：:Specific antagonists were used to determine NK1 and NK2 receptor mediation of the expression of c-Jun and c-Fos inducible transcription factors. (ITFs) in dorsal horn neurons. The induction of c-Jun by C-fiber stimulation was strongly reduced in the superficial laminae by NK1 and NK2 antagonists, but only weakly in th...

journal_title：Neuropeptides

authors： Redburn JL,Leah JD

更新日期：1999-04-01 00:00:00

abstract：:In situ hybridisation histochemistry was used to study the effect of intra-peritoneal reserpine administration on messenger RNA (mRNA) levels in the locus coeruleus (LC) of the rat. 48h after injection, levels of mRNA encoding tyrosine hydroxylase (TH) and neuropeptide Y (NPY) in the LC increased to approximately 250%...

journal_title：Neuropeptides

authors： Foster OJ,Biswas S,Lightman SL

更新日期：1991-03-01 00:00:00

abstract：:The recent surge of scientific interest in 5-hydroxytryptamine3 (5-HT3) receptors can be attributed largely to the rapid increase in the number of potent and selective 5-HT3 receptor antagonists. The availability of a large variety of chemically diverse 5-HT3 compounds allows for a unique opportunity to apply computer...

journal_title：Neuropeptides

authors： Peroutka SJ

更新日期：1991-07-01 00:00:00

abstract：:Somatostatin, substance P, and vasoactive intestinal polypeptide were incubated in an adenylate cyclase assay with a particulate fraction of caudate-putamen tissue of the rat in order to examine the effect of the neuropeptides on G-protein coupled adenylate cyclase in vitro. Somatostatin induced an enhancement of cycl...

journal_title：Neuropeptides

authors： Moser A,Cramer H

更新日期：1992-07-01 00:00:00

abstract：:Superfusion of the dorsal surface of the septum with artificial cerebrospinal fluid containing 10(-10) M [Arg8]-vasopressin (VP) significantly increased the negative (N) wave in field potentials (FPs) elicited in the lateral septum (LS) of rats by stimulation of the fimbria-fornix. A similar increase in the FPs negati...

journal_title：Neuropeptides

authors： Urban IJ,De Wied D

更新日期：1986-01-01 00:00:00

abstract：:Information on the physiological functions of neuropeptide FF; NPFF, a morphine modulating octapeptide in avians is lacking. Thus, we designed a study to investigate the effects of central NPFF with particular emphasis on appetite-related processes. Cobb-500 chicks were intracerebroventricularly (ICV) injected with 0,...

journal_title：Neuropeptides

authors： Cline MA,Nandar W,Rogers JO

更新日期：2007-12-01 00:00:00

abstract：:Prader-Willi syndrome (PWS) is the predominant genetic cause of obesity in humans and is associated with several behavioural phenotypes such as altered motoric function, reduced activity, and learning disabilities. It can include mood instability and, in some cases, psychotic episodes. Recently, the Snord116 gene has ...

journal_title：Neuropeptides

authors： Zieba J,Low JK,Purtell L,Qi Y,Campbell L,Herzog H,Karl T

更新日期：2015-10-01 00:00:00

abstract：:The galanin family currently consists of four peptides, namely galanin, galanin-message associated peptide, galanin-like peptide and alarin. Unlike galanin that signals through three different G protein-coupled receptors; GAL1, GAL2, and GAL3, binding at its N-terminal end, the cognate receptors for other members of t...

journal_title：Neuropeptides

authors： Ihnatko R,Theodorsson E

更新日期：2017-06-01 00:00:00

abstract：:The level of opioid peptides in several brain areas and in the pituitary was estimated in WAG/Rij rats, which are considered to be a genetic animal model for human absence epilepsy. In comparison with three groups of non-epileptic controls, these epileptic rats had an elevated level of the proenkephalin-derived peptid...

journal_title：Neuropeptides

authors： Lasoń W,Przewłocka B,Van Luijtelaar EL,Coenen AM,Przewłocki R

更新日期：1992-03-01 00:00:00

abstract：:The effects of 6-hydroxydopamine (6-OHDA) injected into either the ventral tegmental area (VTA) or the nucleus accumbens on dopamine and its metabolite DOPAC and CCK-immunoreactivity in the nucleus accumbens were studied. Measurements were made 1, 3 and 6 weeks after the lesion in both the anterior and posterior part ...

journal_title：Neuropeptides

authors： Igarashi Y,Wiegant VM,Van Ree JM

更新日期：1989-08-01 00:00:00

abstract：:The aim of the present investigation was to study the effects of pituitary adenylate cyclase-activating polypeptide (PACAP) on morphine withdrawal-induced behavioral changes and hypothermia in male CFLP mice. Elevated plus maze (EPM) and jump tests were used to assess naloxone-precipitated morphine withdrawal-induced ...

journal_title：Neuropeptides

authors： Lipták N,Dochnal R,Babits A,Csabafi K,Szakács J,Tóth G,Szabó G

更新日期：2012-02-01 00:00:00

abstract：:Obesity is a global public health problem. Orexin and endocannabinoid signaling in the hypothalamus have been shown to regulate feeding and are promising molecular targets for obesity treatment. In this study, we attempted to analyze effects of orexin-A and endocannabinoid signaling modulation in the arcuate nucleus (...

journal_title：Neuropeptides

authors： Yang D,Xu L,Guo F,Sun X,Zhang D,Wang M

更新日期：2018-06-01 00:00:00

abstract：:The distributions of four prodynorphin-derived peptides, dynorphin A (1-17), dynorphin A (1-8), dynorphin B, and alpha-neo-endorphin were determined in 10 cortical regions and the striatum of the old world monkey (Macaca nemestrina). alpha-neo-endorphin was the most abundant peptide in both cortex and striatum. The co...

journal_title：Neuropeptides

authors： Healy DJ,Meador-Woodruff JH

更新日期：1994-11-01 00:00:00

abstract：:The biological and immunological properties of insulin-like material produced by brain cells from 12 day old mice, cultured in serum-free media were examined. Differences were seen in the rate of appearance, relative amounts and behaviour on HPLC between immunoreactive and biologically active insulin-like material. Ex...

journal_title：Neuropeptides

authors： Birch NP,Christie DL,Renwick AG

更新日期：1987-05-01 00:00:00

abstract：:Pyroglutamyl diazomethyl ketone and N-benzyloxycarbonyl prolyl prolinal, specific inhibitors of pyroglutamyl peptidase I and prolyl endopeptidase respectively, were used to study the possible role of these enzymes in the regulation of thyrotropin releasing hormone turnover. In vitro thyrotropin releasing hormone relea...

journal_title：Neuropeptides

authors： Charli JL,Mendez M,Joseph-Bravo P,Wilk S

更新日期：1987-05-01 00:00:00

abstract：:A human brain aminopeptidase, which hydrolyses low molecular weight enkephalin-containing peptides (ECPs), was purified to apparent homogeneity from the homogenate of human brain. The enzyme purification involved DEAE-cellulose chromatography and preparative polyacrylamide gel electrophoresis. The purified aminopeptid...

journal_title：Neuropeptides

authors： Duarte GI,Souza FG,Bruno JA,Camargo AC,Carvalho KM

更新日期：1988-08-01 00:00:00

abstract：:Neuropeptide Y (NPY) neurons abundantly innervate the hypothalamus, where NPY is involved in the regulation and integration of a broad range of homeostatic functions. In order to understand NPY-mediated behavioral, autonomic and neuroendocrine effects, it is important to characterize in detail the distribution of the ...

journal_title：Neuropeptides

authors： Fetissov SO,Kopp J,Hökfelt T

更新日期：2004-08-01 00:00:00

abstract：:Lumbar disc herniation is a common cause of radicular pain, but the mechanism remains ambiguous and the treatment stays unsatisfied. Many studies revealed a traditional Chinese medicine puerarin may moderate chronic pain from diabetes and nerve injury. Thus far, the role and mechanism of puerarin in radicular pain is ...

journal_title：Neuropeptides

authors： Zhong Y,Huang YL,Hu YM,Zhu LR,Zhao YS

更新日期：2018-12-01 00:00:00

abstract：:Stretching-yawning syndrome (SYS) and penile erections (PE) are typical components of the behavioral picture induced by intracerebroventricular (i.c.v.) injection of ACTH 1-24. The present study shows that pretreatment with alpha-difluoromethylornithine (DFMO), and irreversible inhibitor of mammalian ornithine decarbo...

journal_title：Neuropeptides

authors： Genedani S,Bernardi M,Bertolini A

更新日期：1984-05-01 00:00:00

abstract：:Plasma protein extravasation in the upper airways of anesthetized guinea pigs was measured with the FITC (Fluorescein isothiocyanate)-dextran technique. The effect of selective tachykinin (NK1 and NK2) receptor agonists and antagonists, capsaicin or antigen was studied. The tachykinin NK1 receptor agonist, [Sar9]subst...

journal_title：Neuropeptides

authors： Evangelista S,Paoli S,Giachetti A,Manzini S

更新日期：1997-02-01 00:00:00

abstract：:The effects of thyroliberin (TRH), a TRH-like tripeptide colon mitosis inhibitor (CMI), a somatostatin analog SMS 201-995 and metoclopramide (dopamine receptor antagonist enhancing prolactin secretion) on rat thymus cell proliferation were investigated. The incorporation of bromodeoxyuridine (BrDU) into thymic cell nu...

journal_title：Neuropeptides

authors： Pawlikowski M,Zerek-Mełeń G,Winczyk K

更新日期：1992-11-01 00:00:00

abstract：:The immune system defends the organism against invading pathogens. In recent decades it became evident that elimination of such pathogens, termination of inflammation, and restoration of host homeostasis all depend on bidirectional crosstalk between the immune system and the neuroendocrine system. This crosstalk is me...

journal_title：Neuropeptides

authors： Lang R,Kofler B

更新日期：2011-02-01 00:00:00