Abstract:
:In situ hybridisation histochemistry was used to study the effect of intra-peritoneal reserpine administration on messenger RNA (mRNA) levels in the locus coeruleus (LC) of the rat. 48h after injection, levels of mRNA encoding tyrosine hydroxylase (TH) and neuropeptide Y (NPY) in the LC increased to approximately 250% of control values (p less than 0.05). The level of beta-tubulin mRNA was unaffected by reserpine administration. The similar and selective increase in TH and NPY mRNA in the LC following reserpine administration suggests that NPY may play a role in the neurotransmitter function of this catecholaminergic nucleus.
journal_name
Neuropeptidesjournal_title
Neuropeptidesauthors
Foster OJ,Biswas S,Lightman SLdoi
10.1016/0143-4179(91)90105-rsubject
Has Abstractpub_date
1991-03-01 00:00:00pages
137-41issue
3eissn
0143-4179issn
1532-2785pii
0143-4179(91)90105-Rjournal_volume
18pub_type
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