Abstract:
:We have found that Neuropeptide Y is colocalized with enkephalin in bovine adrenal chromaffin cells. The two peptides can be found in the same granules in those cells where they coexist. These cells correspond to the adrenergic subpopulation of chromaffin cells since they contain the epinephrine synthetic enzyme, phenylethanolamine N-methyltransferase. Despite their coexistence, production of the two peptides is independently regulated. Enkephalin levels are doubled after nicotinic depolarization (which increases enkephalin synthesis) or after treatment with reserpine (which increases enkephalin precursor processing). Neither of these treatments, acting by different mechanisms, has any effect on the levels of Neuropeptide Y.
journal_name
Neuropeptidesjournal_title
Neuropeptidesauthors
Pruss RM,Mezey E,Forman DS,Eiden LE,Hotchkiss AJ,DiMaggio DA,O'Donohue TLdoi
10.1016/0143-4179(86)90025-9subject
Has Abstractpub_date
1986-05-01 00:00:00pages
315-27issue
4eissn
0143-4179issn
1532-2785pii
0143-4179(86)90025-9journal_volume
7pub_type
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