Abstract：
:The central control of feeding in animals depends upon the alternating actions of orexigenic and anorectic peptides. Studies at understanding the food intake mechanisms have emphasised the role of Neuropeptide Y as a potent orexigenic peptide in the brain. The aim of this study is to investigate the response of NPY system to positive and negative energy states and elucidate a holistic response of NPY expression throughout the brain of a tadpole model. The pre-metamorphic tadpoles of Euphlyctis cyanophlyctis were subjected to fasting, or intra-cranially injected with glucose or 2-deoxy-d-Glucose (2DG)-a metabolic antagonist of glucose and the response of the NPY system in the entire brain was studied using immunohistochemistry. Glucose injections reduced the basal expression of NPY- immunoreactive perikarya (upto 20%) in the olfactory bulb, nucleus pre-opticus, infundibulum, raphe nucleus and the distal lobe of pituitary. These regions responded to the intracranial injections of 2DG by increasing the expression of NPY up to 30%. Animals deprived of food also possessed the same response except that the increase was much intense in the 2DG injected tadpoles. Our observations lead us to the conclusion that NPY containing neurons in the discrete brain areas may be involved in the maintenance of glucose homeostasis in amphibians and, since these regions also contain the glucose sensing neurons, we further suggest that the release of NPY might be regulated by the glucose sensing neurons of the brain.
journal_name
Neuropeptidesjournal_title
Neuropeptidesauthors
Shewale S,Ali I,Hadawale K,Bhargava Sdoi
10.1016/j.npep.2018.06.001subject
Has Abstractpub_date
2018-10-01 00:00:00pages
1-10eissn
0143-4179issn
1532-2785pii
S0143-4179(18)30014-3journal_volume
71pub_type
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