Abstract:
:The relative roles of hypothalamic corticotropin-releasing-hormone (CRH) and vasopressin (AVP) as mediators of the stimulant effect of vasoactive intestinal peptide (VIP) and peptide histidine isoleucine (PHI) on ACTH and corticosterone (CORT) secretion, were examined using receptor blockade of endogenous CRH and AVP. ACTH and CORT secretion were stimulated 6- and 7-fold, respectively, by PVN infusion of VIP (3.0 nmol) and 6- and 9-fold, respectively, by PHI (3.0 nmol). ACTH and CORT stimulation by VIP were inhibited 78 and 72%, respectively, by pretreatment with the CRF antagonist, 59 and 57%, respectively, by pretreatment with the AVP antagonist and about 78% by combined pretreatment with the CRF and AVP antagonists. PHI-induced stimulation of ACTH and CORT was inhibited 89 and 81%, 73 and 59% and 93% by pretreatment with the CRF- or AVP-antagonist or combined administration, respectively. These results support the hypothesis that the activation of the hypothalamic-pituitary-adrenal (HPA) axis by VIP and PHI is mediated through the release of endogenous CRH. AVP also plays a role in this response, possibly by enhancing the activity of CRH in a synergistic manner.
journal_name
Neuropeptidesjournal_title
Neuropeptidesauthors
Alexander LD,Sander LDdoi
10.1016/0143-4179(95)90112-4subject
Has Abstractpub_date
1995-03-01 00:00:00pages
167-73issue
3eissn
0143-4179issn
1532-2785pii
0143-4179(95)90112-4journal_volume
28pub_type
杂志文章相关文献
NEUROPEPTIDES文献大全abstract::The effects of vasoactive intestinal peptide (VIP) on spatial cognitive deficits induced in the rat by injections of scopolamine were examined in a radial arm maze. A single intraperitoneal (i.p.), subcutaneous (s.c.) or intracerebroventricular (i.c.v.) injection of VIP inhibited the reduction in the number of initial...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(94)90124-4
更新日期:1994-03-01 00:00:00
abstract::Bombesin (BN) and its mammalian counterpart gastrin-releasing peptide act as neuroregulatory hormones and tissue-specific growth factors, and have been implicated as peripheral and central satiety-inducing agents. In the present study, the immunohistochemical expression of BN in submandibular, sublingual and parotid g...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/s0143-4179(97)90086-x
更新日期:1997-04-01 00:00:00
abstract::Highly purified porcine neurophysin-II, prepared from pig posterior pituitary lobe tissue was injected into fifteen rabbits in the preparation of anti-neurophysin sera. All antisera, when used in association with immunohistochemical procedures, gave an immunoreaction in structures of the rat hypothalamo-neurohypophysi...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(83)90038-0
更新日期:1983-10-01 00:00:00
abstract::Utilizing a double-blind crossover design, the hormonal effects of high dose, 2 mg/kg, were compared to low dose, 0.4 mg (approx. 5 micrograms/kg), naloxone administration in physically healthy humans. A significant naloxone dose effect on plasma cortisol levels was found (p less than 0.001), but no significant effect...
journal_title:Neuropeptides
pub_type: 临床试验,杂志文章
doi:10.1016/0143-4179(85)90010-1
更新日期:1985-07-01 00:00:00
abstract::Nerve growth factor (NGF) was reported to be increased in the serum and skin of atopic dermatitis (AD) patients, to the extent that serum nerve growth factor levels were proposed to serve as a marker of disease severity. We studied NGF levels in the serum and dermis using skin microdialysis and attempted to correlate ...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2011.07.008
更新日期:2011-12-01 00:00:00
abstract::Endomorphins are newly discovered mu-opioid receptor selective immunocompetent opioid peptides. Endomorphin 1 is predominantly distributed in brain, while endomorphin 2 is widely allocated in the spinal cord. Lately, endomorphins have been investigated as modulators of reactive oxygen and nitrogen species. Nitric oxid...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2009.11.004
更新日期:2010-02-01 00:00:00
abstract::Hippocampal neurogenesis is important for modulating the behavioural responses to stress and for certain forms of learning and memory. The mechanisms underlying the necessary coupling of neuronal activity to neural stem/progenitor cell (NSPC) function remain poorly understood. Within the dentate subgranular stem cell ...
journal_title:Neuropeptides
pub_type: 杂志文章,评审
doi:10.1016/j.npep.2013.10.002
更新日期:2013-12-01 00:00:00
abstract::A series of biologically active peptides and related compounds (opioid peptides, neurotensin, and bradykinin) were used as substrates or competitive inhibitors to study the structural requirements for peptide interaction with endopeptidase 22.19. The kinetics of hydrolysis of these peptides indicated that, in contrast...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(94)90083-3
更新日期:1994-04-01 00:00:00
abstract::In our previous study we have identified PACAP, VIP and their receptors in rat malignant peripheral nerve sheath tumor (MPNST) cells, thus showing anti-apoptotic roles. Recently it has been shown that the tumor suppressor neurofibromin, encoded by the Neurofibromatosis type I (NF1) gene, promotes MPNST cells sensitivi...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2009.10.003
更新日期:2010-02-01 00:00:00
abstract::Experiments were performed to determine whether the renal nerve mediates the renin release induced by intracerebroventricular administration of angiotensin II (ANG II), bradykinin (BK), leucine-enkephalin (Leu-ENK) and neurotensin (NT). In sham-operated rats, both ANG II and NT suppressed plasma renin activity (PRA), ...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(85)90142-8
更新日期:1985-09-01 00:00:00
abstract::Previous data from our labs and from others have demonstrated that intracerebroventricular (ICV) injection of alarin has orexigenic activity and significantly increases plasma luteinizing hormone (LH) secretion in a gonadotropin-releasing hormone (GnRH) dependent manner. The purpose of the current experiments was to d...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2012.08.007
更新日期:2013-02-01 00:00:00
abstract::Acid extracts of cat adrenal medullae were found to contain neurotensin-like (0.71 +/- 0.21nmol/gm), met-enkephalin-like (11.71 +/- 2.87nmol/gm), leu-enkephalin-like (1.95 +/- 0.11nmol/gm) and somatostatin-like (1.57 +/- 0.63pmol/gm) immunoreactivities. Using isolated retrogradely perfused cat adrenal glands the secre...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(82)90061-0
更新日期:1982-10-01 00:00:00
abstract::Neuropeptide Y (NPY) has been implicated in the modulation of important features of neuronal physiology, including calcium homeostasis, neurotransmitter release and excitability. Moreover, NPY has been involved as an important modulator of hippocampal and thalamic circuits, receiving particular attention as an endogen...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2012.09.001
更新日期:2012-12-01 00:00:00
abstract:OBJECTIVE:Potential physiological correlates of stress and the role of stress neuropeptides, other than those of the hypothalamic-pituitary-adrenal axis, in critical illness have not been addressed. We investigated: (a) serum levels of stress neuropeptides (ACTH, substance P (SP), neuropeptide Y (NPY), cortisol, prolac...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2012.07.007
更新日期:2013-02-01 00:00:00
abstract::Orexins are neuropeptides that are localized to neurons in the lateral and dorsal hypothalamus but its receptors are distributed to many different regions of the central nervous system. Orexins are implicated in a variety of physiological functions including sleep regulation, energy homeostats, and stress reactions. F...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2016.12.007
更新日期:2017-02-01 00:00:00
abstract::The aim of the present investigation was to determine if chronic activation of kappa-opioid receptor induces development of tolerance and dependence to kappa-opioid agonists on the isolated right atrium of the rat. Tolerance to the kappa-agonist was induced by chronic administration of U-50,488H, a selective kappa-ago...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/s0143-4179(97)90047-0
更新日期:1997-10-01 00:00:00
abstract::The effects of FMRFamide on passive avoidance behaviour and electroshock-induced amnesia following intracerebroventricular administration were studied in rats. FMRFamide given immediately after the learning trial, or 20 min before the retention trial, attenuated the avoidance response, thereby impairing the consolidat...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(87)90017-5
更新日期:1987-08-01 00:00:00
abstract::In this study, we examined whether the mechanisms mediating the induction of grooming behavior by oxytocin (OT) is similar to mechanisms mediating the effects of OT on uterine contractility. Sprague-Dawley strain female rats were injected intracerebroventricularly (ICV) with OT or OT analogues and then were observed f...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(86)90068-5
更新日期:1986-07-01 00:00:00
abstract::Pheochromocytoma (PC-12) cells exposed to nerve growth factor (NGF) acquire a sympathetic neuron-like phenotype. This NGF-response is blocked by methylation inhibitors and can be mimicked by the farnesylated methylated small GTP-binding protein p21ras. The implicated involvement of prenylation, methylation and a small...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(93)90036-a
更新日期:1993-01-01 00:00:00
abstract::Cholecystokinin-B (CCK-8) is an octapeptide that was initially described in the gastrointestinal tract. Recent studies have shown that this peptide also has an extensive distribution in the central nervous system, including the cerebellum of the opossum. In addition to the protein, binding sites for CCK-8 also have be...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/s0143-4179(96)90035-9
更新日期:1996-12-01 00:00:00
abstract::The regulation of neuropeptide gene expression and their receptors in a tissue specific and stimulus inducible manner will determine in part behaviour and physiology. This can be a dynamic process resulting from short term changes in response to the environment or long term modulation imposed by epigenetically determi...
journal_title:Neuropeptides
pub_type: 杂志文章,评审
doi:10.1016/j.npep.2013.10.003
更新日期:2013-12-01 00:00:00
abstract::The aim of the present work was to study the potential involvement of melanocortin system in the anorectic mechanism of fluoxetine, a selective serotonin reuptake inhibitors, in obese Zucker rats. Male obese Zucker (fa/fa) rats were administered fluoxetine (10 mg/kg; i.p.) daily for two weeks. The control group was gi...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2008.02.002
更新日期:2008-06-01 00:00:00
abstract::3H-Bradykinin binding sites with the characteristics of receptors were identified in homogenates of bovine hippocampus and PC-12 cells. The characteristics of the binding were similar in both types of tissue and paralleled those of the B2 bradykinin receptor. Following exposure to nerve growth factor for 72 hours, the...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(88)90056-x
更新日期:1988-11-01 00:00:00
abstract::The effects of central (clonazepam, an agonist, and FG 7142, an inverse agonist), mixed (diazepam) or peripheral type (Ro 5-4864) benzodiazepine receptor ligands on the action of TRH on the transmurally stimulated rat duodenum and binding of [3H][3-Me-His2] TRH in the rat anterior pituitary, hypothalamus, cortex and b...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(91)90112-v
更新日期:1991-07-01 00:00:00
abstract::The neuropharmacological actions of the agonist analog D-Trp-6-LH-RH were investigated in several tests after subcutaneous administrations to male mice. The doses applied were in the range 1-1000 micrograms/kg. D-Trp-6-LH-RH doses of 10 micrograms/kg and higher induced significant analgesic effects in the hot-plate an...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(90)90053-2
更新日期:1990-10-01 00:00:00
abstract::Neuropeptide Y (NPY) is known to bind to at least two types of receptors (Y1 & Y2). One type (Y2) is able to bind and undergo activation by both NPY and its C-terminal fragments with good potency while the other (Y1) requires the full length of NPY for good potency. For most NPY analogs that have been examined, potenc...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(90)90073-8
更新日期:1990-11-01 00:00:00
abstract::Release of [3H]-acetylcholine (3H-ACh) and muscle contractions in response to cholecystokinin (CCK) were measured and recorded simultaneously from isolated guinea-pig gallbladder. Cholecystokinin octapeptide (CCK8) (10(-10)-10(-7) M) enhanced the release of [3H]ACh and the contractions of the muscle. TTX (10(-6) M) in...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(93)90043-a
更新日期:1993-11-01 00:00:00
abstract::Social conflict and defeat in mice leads to an activation of endogenous opiate systems. The effects of intracerebroventricular administration of the peptide FMRFamide (Phe-Met-Arg-Phe-NH2) and the opiate antagonist naloxone, on aggressive encounters, defeat-induced analgesia and defeat-induced feeding were examined in...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(85)90110-6
更新日期:1985-12-01 00:00:00
abstract::Tachykinins are a family of pronociceptive neuropeptides with a specific role in pain and inflammation. Several mechanisms regulate endogenous tachykinins and Substance P (SP) levels, including the differential expression of protachykinin mRNA and the controlled secretion of tachykinins from neurons. Proteolysis is su...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2016.06.002
更新日期:2016-10-01 00:00:00
abstract:BACKGROUND:Chromogranin A (CgA) in plasma (P-CgA), a neuroendocrine marker of sympathetic stress, has been shown to predict mortality in medical intensive care. We hypothesized that the magnitude of CgA release would reflect stress load, and thereby injury severity in burn intensive care patients. METHODS:Fifty-one co...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2012.10.004
更新日期:2013-06-01 00:00:00