Abstract:
:The neuropharmacological actions of the agonist analog D-Trp-6-LH-RH were investigated in several tests after subcutaneous administrations to male mice. The doses applied were in the range 1-1000 micrograms/kg. D-Trp-6-LH-RH doses of 10 micrograms/kg and higher induced significant analgesic effects in the hot-plate and tail-flick tests, and decreased the open-field parameters (ambulation, rearing, grooming). The 100 and 1000 micrograms/kg doses increased the latencies of picrotoxin-induced seizures, significantly inhibited apomorphine-induced cage climbing and also exerted a cataleptogenic effect. The results indicate that this agonist analog of LH-RH has an inhibitory effect on the central nervous system, and the mechanism of its action may involve dopaminergic transmission and/or endogenous opiates.
journal_name
Neuropeptidesjournal_title
Neuropeptidesauthors
Kádár T,Telegdy G,Schally AVdoi
10.1016/0143-4179(90)90053-2subject
Has Abstractpub_date
1990-10-01 00:00:00pages
81-6issue
2eissn
0143-4179issn
1532-2785pii
0143-4179(90)90053-2journal_volume
17pub_type
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