Abstract:
:A series of biologically active peptides and related compounds (opioid peptides, neurotensin, and bradykinin) were used as substrates or competitive inhibitors to study the structural requirements for peptide interaction with endopeptidase 22.19. The kinetics of hydrolysis of these peptides indicated that, in contrast to other proteases, the substrate specificity of endopeptidase 22.19 is not determined by the amino acids flanking the sensitive bonds of the substrates. The competition between bioactive peptide analogues and the quenched fluorescence substrate of endopeptidase 22.19 indicated that their length and their flexibility may be the dominant factors to explain their binding specificities. These peculiar features of endopeptidase 22.19 may be of importance to understand the physiological processes of conversion and inactivation of biologically active peptides.
journal_name
Neuropeptidesjournal_title
Neuropeptidesauthors
Camargo AC,Gomes MD,Toffoletto O,Ribeiro MJ,Ferro ES,Fernandes BL,Suzuki K,Sasaki Y,Juliano Ldoi
10.1016/0143-4179(94)90083-3subject
Has Abstractpub_date
1994-04-01 00:00:00pages
281-7issue
4eissn
0143-4179issn
1532-2785pii
0143-4179(94)90083-3journal_volume
26pub_type
杂志文章相关文献
NEUROPEPTIDES文献大全abstract::Chronic stress induces the activation of hippocampal microglia, which produces many inflammatory mediators and mediates the occurrence of depression. Two phenotypes of microglia polarization, the classical M1 and alternative M2, play important regulatory roles in neuroinflammation and are involved in the occurrence an...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2020.102006
更新日期:2020-06-01 00:00:00
abstract::The Third Galanin Symposium presented many different and exciting results on galanin research reflecting a major progress since the previous symposium in 1998. A major impression was the many possible relationships of galaninergic mechanisms to important brain functions such as development, cognition and ageing as wel...
journal_title:Neuropeptides
pub_type:
doi:10.1016/j.npep.2005.03.002
更新日期:2005-06-01 00:00:00
abstract::Kyotorphin (KTP), first isolated in the bovine brain and now having been identified in a variety of species, is known most extensively for its analgesic-like properties. KTP indirectly stimulates opioid receptors by releasing methionine enkephalin (met-enkephalin). Stimulation of opioid receptors is linked to hunger p...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2012.10.007
更新日期:2013-06-01 00:00:00
abstract::Enkephalin-immunoreactive neurons have been identified in the central nervous system of the fruit fly Drosophila melanogaster by immunocytochemical techniques. Analyses of fly extracts by high performance liquid chromatography and radioimmunoassay show a relatively complex pattern of immunoreactive compounds. The most...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(83)90012-4
更新日期:1983-12-01 00:00:00
abstract::In this study the influence of acute exposure of gastric mucosa to the sensory neurotoxin capsaicin on basal gastric acid secretion and on secretion induced by 2-deoxy-D-glucose or histamine in conscious dogs with gastric fistulae has been investigated. Under basal conditions intragastric capsaicin (160 microM, 50 ml ...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(92)90128-j
更新日期:1992-12-01 00:00:00
abstract::A series of analogues of substance P, where the Met11 residue was replaced by Glu(OCH2CH3), Glu(OBzl) and Hse(CH3), were synthesized in order to investigate the effect on agonist activity of modifications at the C-terminal residue. The biological activities in the guinea-pig ileum assay (NK1 receptor) and rat [text sa...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(94)90013-2
更新日期:1994-07-01 00:00:00
abstract::Using canine spleen and lung membranes as model systems, we have shown the presence of subtypes of ETB receptors. This classification was done based on the binding profiles of various analogs of ET-1 that have been identified as ETB-selective. Saturation binding experiments performed with [125I] ET-3 and [125I] IRL-12...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(95)90004-7
更新日期:1995-12-01 00:00:00
abstract::3H-Bradykinin binding sites with the characteristics of receptors were identified in homogenates of bovine hippocampus and PC-12 cells. The characteristics of the binding were similar in both types of tissue and paralleled those of the B2 bradykinin receptor. Following exposure to nerve growth factor for 72 hours, the...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(88)90056-x
更新日期:1988-11-01 00:00:00
abstract::A human brain aminopeptidase, which hydrolyses low molecular weight enkephalin-containing peptides (ECPs), was purified to apparent homogeneity from the homogenate of human brain. The enzyme purification involved DEAE-cellulose chromatography and preparative polyacrylamide gel electrophoresis. The purified aminopeptid...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(88)90033-9
更新日期:1988-08-01 00:00:00
abstract::The selectivity of a series of opioid peptides towards the mu-, delta- and kappa-opioid receptors mediating differential inhibition of electrically-induced neurotransmitter release from rat brain slices was studied, viz. cortical [3H]noradrenaline release (inhibited via mu-receptors), striatal [3H]dopamine release (in...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(89)90065-6
更新日期:1989-08-01 00:00:00
abstract::Our previous study showed that intracerebroventricular (ICV) administration of corticotropin-releasing hormone (CRH) produced a significant increase in locomotor activity at a dose of 1 microgram and slow stereotypy with prominent grooming at a dose of 10 micrograms. In addition, the ICV administration of CRH caused a...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(91)90016-c
更新日期:1991-12-01 00:00:00
abstract::The present study was undertaken in order to establish the possible involvement of melatonin in the mechanisms underlying the arginine-vasopressin (AVP) responses to physical exercise and angiotensin II (ANG II). On two mornings at least 1 week apart, normal male subjects were tested with exercise on a bicycle ergomet...
journal_title:Neuropeptides
pub_type: 临床试验,杂志文章
doi:10.1016/s0143-4179(98)90027-0
更新日期:1998-04-01 00:00:00
abstract::6-Beta-fluoro-6-desoxy-oxymorphone (FOXY) is a fluorinated derivative of oxymorphone originally developed as a potential PET scanning ligand. Preliminary work (Rothman et al., Neuropeptides 4: 311-317, 1984) demonstrated that [3H]FOXY selectively labeled mu opioid binding sites with low levels of nonspecific binding. ...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(88)90020-0
更新日期:1988-01-01 00:00:00
abstract::Endomorphins are newly discovered mu-opioid receptor selective immunocompetent opioid peptides. Endomorphin 1 is predominantly distributed in brain, while endomorphin 2 is widely allocated in the spinal cord. Lately, endomorphins have been investigated as modulators of reactive oxygen and nitrogen species. Nitric oxid...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2009.11.004
更新日期:2010-02-01 00:00:00
abstract::The level of opioid peptides in several brain areas and in the pituitary was estimated in WAG/Rij rats, which are considered to be a genetic animal model for human absence epilepsy. In comparison with three groups of non-epileptic controls, these epileptic rats had an elevated level of the proenkephalin-derived peptid...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(92)90037-w
更新日期:1992-03-01 00:00:00
abstract::The orally active, α-hemoglobin derived hemopressin (PVNFKFLSH, Hp(1-9)) and its truncated (PVNFKFL, Hp(1-7) and PVNFKF, Hp(1-6)) and extended ((R)VDPVNFKFLSH, VD-Hp(1-9) and RVD-Hp(1-9)) derivatives have been postulated to be the endogenous peptide ligands of the cannabinoid receptor type 1 (CB1). In an attempt to cr...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2016.02.001
更新日期:2016-08-01 00:00:00
abstract::Arginine vasopressin mediates its effects through vasopressin receptor activation and second messenger production. Recent cloning of the V1a receptor provided the opportunity to investigate the possible signal transduction pathways associated with this single vasopressin receptor subtype. When stably expressed in CHO ...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(94)90017-5
更新日期:1994-07-01 00:00:00
abstract::The neuropharmacological actions of the agonist analog D-Trp-6-LH-RH were investigated in several tests after subcutaneous administrations to male mice. The doses applied were in the range 1-1000 micrograms/kg. D-Trp-6-LH-RH doses of 10 micrograms/kg and higher induced significant analgesic effects in the hot-plate an...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(90)90053-2
更新日期:1990-10-01 00:00:00
abstract::Both endothelins and corticotropin releasing factor (CRF) appear in capsaicin-sensitive neurons. We have investigated the effects of human endothelin-1 (ET-1) and CRF in the guinea-pig ileum longitudinal and circular preparations and sought for ways of specific antagonism. With the aid of tachyphylaxis to capsaicin (i...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/s0143-4179(03)00048-9
更新日期:2003-08-01 00:00:00
abstract::Neuropeptide Y (NPY) causes anxiolytic- and antidepressant-like effects after central administration in rodents. These effects could theoretically be utilized in future gene therapy for anxiety and depression using viral vectors for induction of overexpression of NPY in specific brain regions. Using a recombinant aden...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2014.09.004
更新日期:2014-12-01 00:00:00
abstract::D-Arg containing dipeptides, H-Tyr-D-Arg-OMe and H-Tyr (Et)-D-Arg-OMe, and D-Arg2 substituted N-terminal tetrapeptides of dermorphin, H-Tyr-D-Arg-Phe-Gly-OEt and H-Tyr (Et)-D-Arg-Phe-Gly-OEt administered intracerebroventricularly exhibited dose-dependent antinociceptive activities in mice as measured by the tail press...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(84)90001-5
更新日期:1984-06-01 00:00:00
abstract::Cocaine- and amphetamine-regulated transcript (CART) peptides have a wide CNS distribution and appear to play an important role in a number of physiological processes including reward and reinforcement, feeding, locomotion, stress responses and perception of pain. We have further investigated the expression of CART pe...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2007.11.001
更新日期:2008-02-01 00:00:00
abstract::Neuropeptide Y (NPY) potentiates noradrenaline (NA)-evoked constriction of circular segments of the rabbit femoral artery. The potentiation occurs exclusively in the lower concentration-range of the agonist NA (10(-8)-3 x 10(-7) M) without any change in maximum contractile effect. NPY per se is without contractile eff...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(91)90068-t
更新日期:1991-05-01 00:00:00
abstract::Alzheimer's disease (AD) is a progressive neurodegenerative disease that deeply affects patients, their family and society. Although scientists have made intense efforts in seeking the cure for AD, no drug available today is able to stop AD progression. In this context, compounds isolated from animal venom are potenti...
journal_title:Neuropeptides
pub_type: 杂志文章,评审
doi:10.1016/j.npep.2017.11.010
更新日期:2018-02-01 00:00:00
abstract::We have found that Neuropeptide Y is colocalized with enkephalin in bovine adrenal chromaffin cells. The two peptides can be found in the same granules in those cells where they coexist. These cells correspond to the adrenergic subpopulation of chromaffin cells since they contain the epinephrine synthetic enzyme, phen...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(86)90025-9
更新日期:1986-05-01 00:00:00
abstract::The effects of the GABAergic drugs nipecotic acid, Gabrene, baclofen and metatolylcarbamide (MTC), when given alone or in combination at subthreshold doses with AT II also at a subthreshold dose effective on PTZ-kindling in mice were studied. PTZ-kindling was provoked by intraperitoneal (i.p.) injections of PTZ (40 mg...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(95)90071-3
更新日期:1995-01-01 00:00:00
abstract::In this study, we examined whether the mechanisms mediating the induction of grooming behavior by oxytocin (OT) is similar to mechanisms mediating the effects of OT on uterine contractility. Sprague-Dawley strain female rats were injected intracerebroventricularly (ICV) with OT or OT analogues and then were observed f...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(86)90068-5
更新日期:1986-07-01 00:00:00
abstract::Striatal neuropeptide Y-like immunoreactivity (NPY-LI) levels were investigated in naive rats after acute, subchronic (14 days) or chronic (28 days) intraperitoneal (i.p.) treatment with chlorpromazine (2 or 10mg/kg), haloperidol (0.5 or 2 mg/kg), (+/-)sulpiride (50 or 100 mg/kg) or clozapine (10 or 25 mg/kg), and in ...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/s0143-4179(98)90074-9
更新日期:1998-10-01 00:00:00
abstract::A role for beta-endorphin (beta-END) in the pathophysiology of major depressive disorder (MDD) is suggested by both animal research and studies examining clinical populations. The major etiological theories of depression include brain regions and neural systems that interact with opioid systems and beta-END. Recent pr...
journal_title:Neuropeptides
pub_type: 杂志文章,评审
doi:10.1016/j.npep.2009.06.004
更新日期:2009-10-01 00:00:00
abstract::The immune system defends the organism against invading pathogens. In recent decades it became evident that elimination of such pathogens, termination of inflammation, and restoration of host homeostasis all depend on bidirectional crosstalk between the immune system and the neuroendocrine system. This crosstalk is me...
journal_title:Neuropeptides
pub_type: 杂志文章,评审
doi:10.1016/j.npep.2010.10.005
更新日期:2011-02-01 00:00:00