Galanin and its receptors: introduction to the Third International Symposium, San Diego, California, USA, 21-22 October 2004.

Abstract:

:The Third Galanin Symposium presented many different and exciting results on galanin research reflecting a major progress since the previous symposium in 1998. A major impression was the many possible relationships of galaninergic mechanisms to important brain functions such as development, cognition and ageing as well as many aspects related to a wide spectrum of diseases, including Alzheimer's disease, anxiety/depression, addiction, obesity, pain and tumour growth. These studies were based on an extensive armament of methodologies including various strains of transgenic mice. Unfortunately, the pharmaceutical industry had only a minor participation. Nevertheless, exciting developments in the generation of agonists and antagonists are emerging, providing hope that we at the next symposium will be able to validitate many of the challenging hypotheses concerning galanin and disease with the help of pharmacological tools.

journal_name

Neuropeptides

journal_title

Neuropeptides

authors

Hökfelt T

doi

10.1016/j.npep.2005.03.002

keywords:

subject

Has Abstract

pub_date

2005-06-01 00:00:00

pages

125-42

issue

3

eissn

0143-4179

issn

1532-2785

pii

S0143-4179(05)00033-8

journal_volume

39

pub_type

  • Involvement of tachykinin NK1 receptors in plasma protein extravasation induced by tachykinins in the guinea pig upper airways.

    abstract::Plasma protein extravasation in the upper airways of anesthetized guinea pigs was measured with the FITC (Fluorescein isothiocyanate)-dextran technique. The effect of selective tachykinin (NK1 and NK2) receptor agonists and antagonists, capsaicin or antigen was studied. The tachykinin NK1 receptor agonist, [Sar9]subst...

    journal_title:Neuropeptides

    pub_type: 杂志文章

    doi:10.1016/s0143-4179(97)90022-6

    authors: Evangelista S,Paoli S,Giachetti A,Manzini S

    更新日期:1997-02-01 00:00:00

  • Cerebrospinal fluid (CSF) neuropeptide Y- and somatostatin-like immunoreactivities in man.

    abstract::We have measured cerebrospinal fluid (CSF) neuropeptide Y-like immunoreactivity (NPY-LI) and somatostatin-like immunoreactivity (SLI) in control subjects and in patients with various neurologic disorders. We observed a significant reduction in CSF SLI in control subjects over 60 years of age, compared with the younger...

    journal_title:Neuropeptides

    pub_type: 杂志文章

    doi:10.1016/0143-4179(94)90058-2

    authors: Maeda K,Yasuda M,Kaneda H,Maeda S,Yamadori A

    更新日期:1994-12-01 00:00:00

  • Distribution of NPY receptors in the hypothalamus.

    abstract::Neuropeptide Y (NPY) neurons abundantly innervate the hypothalamus, where NPY is involved in the regulation and integration of a broad range of homeostatic functions. In order to understand NPY-mediated behavioral, autonomic and neuroendocrine effects, it is important to characterize in detail the distribution of the ...

    journal_title:Neuropeptides

    pub_type: 杂志文章,评审

    doi:10.1016/j.npep.2004.05.009

    authors: Fetissov SO,Kopp J,Hökfelt T

    更新日期:2004-08-01 00:00:00

  • Characterization of human placental opioid receptors by 3H-ethylketocyclazocine and 3H-naloxone binding.

    abstract::The human placenta contains membrane bound opioid receptors. The binding of the antagonist naloxone and the fairly kappa-selective agonist EKC were studied in the microvillous membrane fraction. In both cases high affinity binding sites were detected with Kd values in the nanomolar range. A series of kappa-selective l...

    journal_title:Neuropeptides

    pub_type: 杂志文章

    doi:10.1016/0143-4179(88)90050-9

    authors: Agbas A,Simon J,Avni Oktem H,Varga E,Borsodi A

    更新日期:1988-10-01 00:00:00

  • Plasma Kallikrein and Angiotensin I-converting enzyme N- and C-terminal domain activities are modulated by the insertion/deletion polymorphism.

    abstract::Angiotensin I-converting enzyme (ACE) is recognized as one of the main effector molecules involved in blood pressure regulation. In the last few years some polymorphisms of ACE such as the insertion/deletion (I/D) polymorphism have been described, but their physiologic relevance is poorly understood. In addition, few ...

    journal_title:Neuropeptides

    pub_type: 杂志文章

    doi:10.1016/j.npep.2009.12.003

    authors: Almeida SS,Barros CC,Moraes MR,Russo FJ,Haro AS,Rosa TS,Alves MF,Pesquero JB,Carmona AK,Bacurau RF,Araújo RC

    更新日期:2010-04-01 00:00:00

  • Y5 neuropeptide Y receptor overexpression in mice neither affects anxiety- and depression-like behaviours nor seizures but confers moderate hyperactivity.

    abstract::Neuropeptide Y (NPY) has been implicated in anxiolytic- and antidepressant-like behaviour as well as seizure-suppressant effects in rodents. Although these effects appear to be predominantly mediated via other NPY receptors (Y1 and/or Y2), several studies have also indicated a role for Y5 receptors. Gene therapy using...

    journal_title:Neuropeptides

    pub_type: 杂志文章

    doi:10.1016/j.npep.2012.01.002

    authors: Olesen MV,Christiansen SH,Gøtzsche CR,Holst B,Kokaia M,Woldbye DP

    更新日期:2012-04-01 00:00:00

  • Evidence for the involvement of an opioid system in sciatic nerve of Rana ridibunda.

    abstract::The effect of opioid peptide, D-alanine2-leucine-enkephalin and opioid homolog peptide, des-tyrosine-methionine-enkephalin in concentrations of 1 x 10(-6) and 1 x 10(-5) M was investigated on the action potential parameters of frog sciatic nerve. Des-tyrosine-methionine-enkephalin was used as the control to prove the ...

    journal_title:Neuropeptides

    pub_type: 杂志文章

    doi:10.1016/j.npep.2004.03.003

    authors: Camlica Y,Aşkin A,Cömelekoğlu U

    更新日期:2004-04-01 00:00:00

  • The evidence of thyroliberin/triiodothyronine control of TSH secretory response from human peripheral blood monocytes cultured in vitro.

    abstract::Immune system function has been shown to be under the influence of various neuromodulators and endocrine system peptides. This in vitro study describes the stimulatory effect of thyrotropin releasing hormone (thyroliberin, TRH) on thyrotropin (TSH) release from cultured human peripheral blood monocytes. The stimulator...

    journal_title:Neuropeptides

    pub_type: 杂志文章

    doi:10.1016/0143-4179(93)90065-i

    authors: Komorowski J,Stepień H,Pawlikowski M

    更新日期:1993-07-01 00:00:00

  • The interaction of brain insulin receptors with wheat germ agglutinin.

    abstract::Brain insulin receptors adsorb to and are recoverable from wheat germ agglutinin-agarose (WGA) columns. Similar results are obtained using dissuccinimidyl suberate (DSS)-crosslinked receptors or photo-affinity labeled receptors. WGA can be used for partial purification of brain insulin receptors provided the appropria...

    journal_title:Neuropeptides

    pub_type: 杂志文章

    doi:10.1016/0143-4179(87)90025-4

    authors: Shemer J,LeRoith D

    更新日期:1987-01-01 00:00:00

  • Regional brain concentrations of neurotensin following amygdaloid kindled and cortical suprathreshold stimulation-induced seizures in the rat.

    abstract::There is now considerable evidence that putative neuropeptides are involved in epileptogenic processes. Neurotensin (NT), which affects neuronal excitability in many parts of the CNS, is potentially relevant to the kindling phenomenon, but has not previously been studied in the kindling model of epilepsy. This study c...

    journal_title:Neuropeptides

    pub_type: 杂志文章

    doi:10.1016/0143-4179(88)90014-5

    authors: Shulkes A,Harris QL,Lewis SJ,Vajda JE,Jarrott B

    更新日期:1988-02-01 00:00:00

  • Skeletal phenotype of the neuropeptide Y knockout mouse.

    abstract::Neuropeptide Y (NPY) is involved in multiple processes such as behavior, energy and bone metabolism. Previous studies have relied on global NPY depletion to examine its effects on bone. However, this approach is unable to distinguish the central or local source of NPY influencing bone. Our aim was to identify which ce...

    journal_title:Neuropeptides

    pub_type: 杂志文章

    doi:10.1016/j.npep.2018.11.009

    authors: Wee NKY,Sinder BP,Novak S,Wang X,Stoddard C,Matthews BG,Kalajzic I

    更新日期:2019-02-01 00:00:00

  • Neuropeptide Y-like immunoreactivity in lumbar cerebrospinal fluid of patients after severe head trauma.

    abstract::We studied head-injured patients assessed after admission to the hospital according to the Glasgow coma scale (3-8 points). All of them underwent surgical procedure after neuroradiological examination. Due to therapeutic problems, some of these patients had lumbar puncture on the fourth day following surgery. The cont...

    journal_title:Neuropeptides

    pub_type: 杂志文章

    doi:10.1016/s0143-4179(97)90012-3

    authors: Stachura Z,Obuchowicz E,Herman ZS

    更新日期:1997-02-01 00:00:00

  • Galanin induced in sympathetic neurons after axotomy is anterogradely transported toward regenerating nerve endings.

    abstract::Peripheral neurons begin to express galanin after axotomy. When neurons in the superior cervical ganglion were axotomized near (about 2 mm) from the ganglion, galanin-like immunoreactivity (IR) was maximal within 72 h. Axotomy of neurons in the middle and inferior cervical ganglion complex (MICG), which could be perfo...

    journal_title:Neuropeptides

    pub_type: 杂志文章

    doi:10.1016/s0143-4179(98)90045-2

    authors: Shadiack AM,Zigmond RE

    更新日期:1998-06-01 00:00:00

  • Orphan neuropeptides. Novel neuropeptides modulating sleep or feeding.

    abstract::Neuropeptides form the largest family of modulators of synaptic transmission. Until 1995 some 60 different neuropeptides had been found. With the recognition that all neuropeptides act by binding to G protein coupled receptors (GPCRs), a new approach relying on the use of orphan GPCRs as targets was designed to identi...

    journal_title:Neuropeptides

    pub_type: 杂志文章,评审

    doi:10.1016/j.npep.2006.04.002

    authors: Chung S,Civelli O

    更新日期:2006-08-01 00:00:00

  • Enkephalin and neuropeptide Y: two colocalized neuropeptides are independently regulated in primary cultures of bovine chromaffin cells.

    abstract::We have found that Neuropeptide Y is colocalized with enkephalin in bovine adrenal chromaffin cells. The two peptides can be found in the same granules in those cells where they coexist. These cells correspond to the adrenergic subpopulation of chromaffin cells since they contain the epinephrine synthetic enzyme, phen...

    journal_title:Neuropeptides

    pub_type: 杂志文章

    doi:10.1016/0143-4179(86)90025-9

    authors: Pruss RM,Mezey E,Forman DS,Eiden LE,Hotchkiss AJ,DiMaggio DA,O'Donohue TL

    更新日期:1986-05-01 00:00:00

  • Orexin-A and endocannabinoid signaling regulate glucose-responsive arcuate nucleus neurons and feeding behavior in obese rats.

    abstract::Obesity is a global public health problem. Orexin and endocannabinoid signaling in the hypothalamus have been shown to regulate feeding and are promising molecular targets for obesity treatment. In this study, we attempted to analyze effects of orexin-A and endocannabinoid signaling modulation in the arcuate nucleus (...

    journal_title:Neuropeptides

    pub_type: 杂志文章

    doi:10.1016/j.npep.2018.04.001

    authors: Yang D,Xu L,Guo F,Sun X,Zhang D,Wang M

    更新日期:2018-06-01 00:00:00

  • Chronic pain in the rat: selective alterations in CNS and pituitary pools of dynorphin as compared to vasopressin.

    abstract::Inoculation of rats at the tail-base with Mycobacterium led to arthritic swelling and inflammation of all four limbs. Immunoreactive (ir)-dynorphin (DYN) increased in anterior but not neurointermediate pituitary. In the brain, only thalamus showed a rise and, in spinal cord, a large elevation was seen. Ir-vasopressin ...

    journal_title:Neuropeptides

    pub_type: 杂志文章

    doi:10.1016/0143-4179(85)90044-7

    authors: Millan MJ,Millan MH,Pilcher CW,Colpaert FC,Herz A

    更新日期:1985-02-01 00:00:00

  • Alarin 6-25Cys antagonizes alarin-specific effects on food intake and luteinizing hormone secretion.

    abstract::Previous data from our labs and from others have demonstrated that intracerebroventricular (ICV) injection of alarin has orexigenic activity and significantly increases plasma luteinizing hormone (LH) secretion in a gonadotropin-releasing hormone (GnRH) dependent manner. The purpose of the current experiments was to d...

    journal_title:Neuropeptides

    pub_type: 杂志文章

    doi:10.1016/j.npep.2012.08.007

    authors: Fraley GS,Leathley E,Nickols A,Gerometta E,Coombs E,Colton S,Gallemore S,Lindberg A,Kofler B

    更新日期:2013-02-01 00:00:00

  • Expression of cocaine- and amphetamine-regulated transcript (CART) peptides at climbing fibre-Purkinje cell synapses in the rat vestibular cerebellum.

    abstract::Cocaine- and amphetamine-regulated transcript (CART) peptides have a wide CNS distribution and appear to play an important role in a number of physiological processes including reward and reinforcement, feeding, locomotion, stress responses and perception of pain. We have further investigated the expression of CART pe...

    journal_title:Neuropeptides

    pub_type: 杂志文章

    doi:10.1016/j.npep.2007.11.001

    authors: Press DA,Wall MJ

    更新日期:2008-02-01 00:00:00

  • The analgesic effect of orexin-A in a murine model of chemotherapy-induced neuropathic pain.

    abstract::Orexins are neuropeptides that are localized to neurons in the lateral and dorsal hypothalamus but its receptors are distributed to many different regions of the central nervous system. Orexins are implicated in a variety of physiological functions including sleep regulation, energy homeostats, and stress reactions. F...

    journal_title:Neuropeptides

    pub_type: 杂志文章

    doi:10.1016/j.npep.2016.12.007

    authors: Toyama S,Shimoyama N,Shimoyama M

    更新日期:2017-02-01 00:00:00

  • The orexinergic neural pathway from the lateral hypothalamus to the nucleus accumbens and its regulation of palatable food intake.

    abstract:OBJECTIVE:To explore the orexinergic pathway from the lateral hypothalamus (LHA) to the nucleus accumbens (NAc) and its regulation on the palatable food intake. METHODS:Fluorescent gold retrograde tracing combined with fluoro-immunohistochemical staining were used to observe the projection of orexinergic neurons from ...

    journal_title:Neuropeptides

    pub_type: 杂志文章

    doi:10.1016/j.npep.2020.102028

    authors: Liu X,Gao S,Zhang N,Jin T,Sun X,Luan X,Xu L,Guo F

    更新日期:2020-04-01 00:00:00

  • Changes in thymus size, cellularity and relation between thymocyte subpopulations in young adult rats induced by somatostatin-14.

    abstract::The role of somatostatin on inhibition of both normal and tumor cell cycle, secretion of endocrine and exocrine cells, as well as induction apoptosis is well documented. However, its effect on T cell development and thymic structure is not fully clarified. In order to investigate the influence of somatostatin in vivo ...

    journal_title:Neuropeptides

    pub_type: 杂志文章

    doi:10.1016/j.npep.2007.06.003

    authors: Petrović-Dergović DM,Rakin AK,Dimitrijević LA,Ristovski JS,Kustrimović NZ,Mićić MV

    更新日期:2007-12-01 00:00:00

  • Preoperative concentration of beta-lipotropin immunoreactive material in cerebrospinal fluid: a predictor of postoperative pain?

    abstract::Levels of beta-endorphin immunoreactive material (IRM) in cerebrospinal fluid (CSF) have been reported to correlate inversely with postoperative morphine requirement. Considering proopiomelanocortin (POMC) derivatives as predictors for sensitivity to postoperative pain, we determined authentic beta-endorphin (beta-end...

    journal_title:Neuropeptides

    pub_type: 杂志文章

    doi:10.1016/j.npep.2005.10.001

    authors: Matejec R,Schulz A,Mühling J,Uhlich H,Bödeker RH,Hempelmann G,Teschemacher H

    更新日期:2006-02-01 00:00:00

  • Development of tolerance to the muscular rigidity produced by morphine and replacement by stereotypic behaviour.

    abstract::After chronic treatment with morphine, the muscular rigidity mediated by opioid receptors in the striatum, was gradually replaced by stereotypic behaviour indicating an increased nigrostriatal dopaminergic activity. These results suggest that one behavioural pattern, originating in the striatum, was replaced by anothe...

    journal_title:Neuropeptides

    pub_type: 杂志文章

    doi:10.1016/0143-4179(84)90018-0

    authors: Themann P,Havemann U,Kuschinsky K

    更新日期:1984-12-01 00:00:00

  • Vascular neuropeptide Y Y1-receptors in the rat kidney: vasoconstrictor effects and expression of Y1-receptor mRNA.

    abstract::Neuropeptide Y (NPY) -receptor subtypes were studied in the rat kidney in vivo by systemic administration of NPY, the two agonists [Leu(31), Pro(34)]NPY (Y1-receptor agonist) and NPY (13-36) (Y2-receptor agonist), or the Y1-receptor antagonist BIBP 3226. Effects on mean arterial blood pressure (MAP) and renal arterial...

    journal_title:Neuropeptides

    pub_type: 杂志文章

    doi:10.1054/npep.1999.0755

    authors: Modin A,Malmström RE,Meister B

    更新日期:1999-08-01 00:00:00

  • The role of beta-endorphin in the pathophysiology of major depression.

    abstract::A role for beta-endorphin (beta-END) in the pathophysiology of major depressive disorder (MDD) is suggested by both animal research and studies examining clinical populations. The major etiological theories of depression include brain regions and neural systems that interact with opioid systems and beta-END. Recent pr...

    journal_title:Neuropeptides

    pub_type: 杂志文章,评审

    doi:10.1016/j.npep.2009.06.004

    authors: Hegadoren KM,O'Donnell T,Lanius R,Coupland NJ,Lacaze-Masmonteil N

    更新日期:2009-10-01 00:00:00

  • Behavioural characteristics of the Prader-Willi syndrome related biallelic Snord116 mouse model.

    abstract::Prader-Willi syndrome (PWS) is the predominant genetic cause of obesity in humans and is associated with several behavioural phenotypes such as altered motoric function, reduced activity, and learning disabilities. It can include mood instability and, in some cases, psychotic episodes. Recently, the Snord116 gene has ...

    journal_title:Neuropeptides

    pub_type: 杂志文章

    doi:10.1016/j.npep.2015.06.009

    authors: Zieba J,Low JK,Purtell L,Qi Y,Campbell L,Herzog H,Karl T

    更新日期:2015-10-01 00:00:00

  • Molecular graphics applied to 5-HT3 ligands.

    abstract::The recent surge of scientific interest in 5-hydroxytryptamine3 (5-HT3) receptors can be attributed largely to the rapid increase in the number of potent and selective 5-HT3 receptor antagonists. The availability of a large variety of chemically diverse 5-HT3 compounds allows for a unique opportunity to apply computer...

    journal_title:Neuropeptides

    pub_type: 杂志文章,评审

    doi:10.1016/0143-4179(91)90079-x

    authors: Peroutka SJ

    更新日期:1991-07-01 00:00:00

  • SR 48692-sensitive neurotensin receptors modulate acetylcholine release in the rat striatum.

    abstract::The effects of stimulation and blockade of neurotensin receptors on striatal acetylcholine release were examined in anaesthetized rats using microdialysis. Local perfusion with neurotensin (100 nM) did not influence the release of acetylcholine. Application of neurotensin (100 nM) 30 min after haloperidol (125 microgr...

    journal_title:Neuropeptides

    pub_type: 杂志文章

    doi:10.1016/0143-4179(95)90053-5

    authors: Steinberg R,Rodier D,Mons G,Gully D,Le Fur G,Soubrié P

    更新日期:1995-07-01 00:00:00

  • Blockage of spinal endothelin A receptors attenuates bone cancer pain via regulation of the Akt/ERK signaling pathway in mice.

    abstract::Bone cancer pain (BCP) is a common source of pain in patients with advanced stage and metastatic cancer; however, existing treatment for this kind of pain remains deficient. Being closely related to sensory change and inflammatory pain in both the central and peripheral nervous systems, endothelin A receptor (ETAR) pl...

    journal_title:Neuropeptides

    pub_type: 杂志文章

    doi:10.1016/j.npep.2018.01.003

    authors: Han MM,Yang CW,Cheung CW,Li J

    更新日期:2018-04-01 00:00:00