The orexinergic neural pathway from the lateral hypothalamus to the nucleus accumbens and its regulation of palatable food intake.


OBJECTIVE:To explore the orexinergic pathway from the lateral hypothalamus (LHA) to the nucleus accumbens (NAc) and its regulation on the palatable food intake. METHODS:Fluorescent gold retrograde tracing combined with fluoro-immunohistochemical staining were used to observe the projection of orexinergic neurons from LHA to NAc. The orexin-A expression in LHA and c-Fos in NAc were studied after electrical stimulation of LHA. The firing rates of neurons were monitored by single-unit extracellular electric discharge recording and the palatable food intake were measured after orexin microinjection in NAc or electrical stimulation of LHA. RESULTS:(1) Fluorescent gold retrograde tracing combined with fluoro-immunohistochemical staining showed some orexinergic neural projection from the LHA to the NAc shell. (2) Electrical stimulation of LHA significantly enhanced the expression of orexin-A in LHA and the expression of c-Fos in NAc (P < .05). (3) The results of single-unit extracellular discharge recording showed that the microinjection of orexin in NAc or electrical stimulation of LHA significantly increased the discharge activity of gastric distension responsive neurons in NAc, and the effect could be partly blocked by pretreatment of orexin-A receptor inhibitor SB334867 in NAc (P < .05). (4) Microinjection orexin-A in NAc or electrical stimulation of LHA significantly increased the palatable food intake in rats, and the effect also was partly inhibited by pretreatment of SB334867 in NAc (P < .05). CONCLUSION:There is an orexinergic pathway from LHA to NAc, which may have potential regulatory effects on food reward and obesity.






Liu X,Gao S,Zhang N,Jin T,Sun X,Luan X,Xu L,Guo F




Has Abstract


2020-04-01 00:00:00












  • The galanin peptide family in inflammation.

    abstract::The immune system defends the organism against invading pathogens. In recent decades it became evident that elimination of such pathogens, termination of inflammation, and restoration of host homeostasis all depend on bidirectional crosstalk between the immune system and the neuroendocrine system. This crosstalk is me...


    pub_type: 杂志文章,评审


    authors: Lang R,Kofler B

    更新日期:2011-02-01 00:00:00

  • Ifenprodil blocks the excitatory effects of the opioid peptide dynorphin 1-17 on NMDA receptor-mediated currents in the CA3 region of the guinea pig hippocampus.

    abstract::This study found that dynorphin had a biphasic concentration response relationship on N-methyl-D-aspartate (NMDA) receptor-mediated currents in the CA3 region of the guinea pig hippocampal slice. A previous study demonstrated that the inhibitory effect was mediated by a kappa 2 opioid receptor. In the present study, t...


    pub_type: 杂志文章


    authors: Caudle RM,Dubner R

    更新日期:1998-02-01 00:00:00

  • Specific inhibitors of pyroglutamyl peptidase I and prolyl endopeptidase do not change the in vitro release of TRH or its content in rodent brain.

    abstract::Pyroglutamyl diazomethyl ketone and N-benzyloxycarbonyl prolyl prolinal, specific inhibitors of pyroglutamyl peptidase I and prolyl endopeptidase respectively, were used to study the possible role of these enzymes in the regulation of thyrotropin releasing hormone turnover. In vitro thyrotropin releasing hormone relea...


    pub_type: 杂志文章


    authors: Charli JL,Mendez M,Joseph-Bravo P,Wilk S

    更新日期:1987-05-01 00:00:00

  • Cardiac dynamics in corticotropin-releasing factor receptor subtype-2 deficient mice.

    abstract::The action of corticotropin-releasing factor (CRF) is mediated by two recently identified receptors, CRFR1 and CRFR2, that differ with respect to their anatomical distribution and pharmacologic ligand-binding properties. Here we show by an analysis of circadian heartbeat interval fluctuations that CRFR2-deficiency in ...


    pub_type: 杂志文章


    authors: Stiedl O,Meyer M

    更新日期:2003-02-01 00:00:00

  • Differential effects of substance P or hemokinin-1 on transient receptor potential channels, TRPV1, TRPA1 and TRPM8, in the rat.

    abstract::Two tachykinin peptides, substance P (SP) and hemokinin-1 (HK-1), and three transient receptor potential (TRP) channels, TRPV1, TRPA1 and TRPM8, are similarly localized in the spinal dorsal horn and dorsal root ganglion, suggesting that TRP channels may be related or modulated by these tachykinin peptides. Thus, to cl...


    pub_type: 杂志文章


    authors: Naono-Nakayama R,Sunakawa N,Ikeda T,Nishimori T

    更新日期:2010-02-01 00:00:00

  • An immunocytochemical mapping of beta-endorphin (1-27) in the cat diencephalon.

    abstract::The distribution of beta-endorphin (1-27) immunoreactive cell bodies and fibres was studied in the diencephalon of the cat using an indirect immunoperoxidase technique. In the thalamus, almost all the immunoreactive fibres were found in the midline region and in nuclei located near the midline, whereas in the hypothal...


    pub_type: 杂志文章


    authors: Coveñas R,de León M,Narváez JA,Tramu G,Aguirre JA,González-Barón S

    更新日期:1996-06-01 00:00:00

  • Microheterogeneous neurophysins in newly formed and aged neurosecretory granules.

    abstract::To find out, whether microheterogeneity of neurophysins is due to aging of neurosecretory granules we investigated neurophysin proteins of porcine origin from newly formed and aged granules, as well as from two different extraction methods from whole posterior pituitary glands by high performance liquid chromatography...


    pub_type: 杂志文章


    authors: Richter WO,Schwandt P

    更新日期:1983-12-01 00:00:00

  • Neuropeptides are associated with pain threshold and bone microstructure in ovariectomized rats.

    abstract:OBJECTIVES:Postmenopausal osteoporosis (PMO) is a metabolic skeletal disorder with impaired bone density and bone quality in postmenopausal women. The aim of the present study was to investigate the correlation between neuropeptides, bone microstructure and pain threshold in ovariectomized (OVX) rats. METHODS:Female r...


    pub_type: 杂志文章


    authors: Xie W,Li F,Han Y,Li Z,Xiao J

    更新日期:2020-06-01 00:00:00

  • Partial blockade of neurotensin-induced hypotension in rats by nephrectomy captopril and saralasin. Possible mechanisms.

    abstract::We have assessed the influence of acute bilateral nephrectomy, of captopril and saralasin, on the hypotensive activity of neurotensin (NT) and of various hypotensive drugs in pentobarbital-anesthetized rats. The results show that the hypotensive activity of NT and of compound 48/80 (C48/80), in contrast to that of his...


    pub_type: 杂志文章


    authors: Kérouac R,St-Pierre S,Manning M,Rioux F

    更新日期:1983-04-01 00:00:00

  • Natural killer cell activity in patients with neuroendocrine tumours of the gastrointestinal tract; relation with circulating gastrointestinal hormones.

    abstract::We have evaluated the peripheral blood natural killer (NK) cell activity and the in vitro effect of recombinant gamma-interferon (r gamma-IFN) on NK cell activity in 23 patients with a neuroendocrine tumour of the pancreas, small intestine or liver, and 23 healthy controls. Patients with a gastrinoma showed a NK cell ...


    pub_type: 杂志文章


    authors: Aparicio-Pagés MN,Verspaget HW,Peña AS,Jansen JB,Lamers CB

    更新日期:1991-09-01 00:00:00

  • The human neurokinin B gene, TAC3, and its promoter are regulated by Neuron Restrictive Silencing Factor (NRSF) transcription factor family.

    abstract::We have previously shown that one of the major determinants directing the expression of the preprotachykinin-A (TAC1) gene, which encodes the neuropeptide substance P, is the transcription factor Neuronal Restrictive Silencer Factor (NSRF), which is also termed Repressor Element-1 Silencing Factor (REST). In rodent mo...


    pub_type: 杂志文章


    authors: Gillies S,Haddley K,Vasiliou S,Bubb VJ,Quinn JP

    更新日期:2009-08-01 00:00:00

  • Involvement of the central serotoninergic system in the changes of leu-enkephalin level in discrete rat brain areas.

    abstract::The effects of acute and chronic treatment with LSD and acute treatment with mescaline, m-CPP, citalopram and fenfluramine on leu-enkephalin (LENK) content in rat brain were examined. The acute LSD treatment was found to decrease and chronic treatment to increase the LENK content in the frontal cortex. In the thalamus...


    pub_type: 杂志文章


    authors: Kmieciak-Kołada K,Kowalski J

    更新日期:1986-05-01 00:00:00

  • Effect of a neurokinin-1 (NK1) receptor antagonist on oedema formation induced by tachykinins, carrageenin and an allergic response in guinea-pig skin.

    abstract::The effect of the neurokinin-1 (NK1) receptor antagonist RP67580 in modulating inflammatory oedema formation has been investigated in guinea-pig skin. Oedema formation was measured over 30 min by the extravascular accumulation of intravenously-injected 125I-albumin in the anaesthetised guinea-pig. RP67580 was injected...


    pub_type: 杂志文章


    authors: Wilsoncroft P,Euzger H,Brain SD

    更新日期:1994-06-01 00:00:00

  • Expression of neuropeptide receptor mRNA during osteoblastic differentiation of mouse iPS cells.

    abstract::Various studies have shown a relationship between nerves and bones. Recent evidence suggests that both sensory and sympathetic nerves affect bone metabolism; however, little is known about how neuropeptides are involved in the differentiation of pluripotent stem cells into osteoblastic (OB) cells. To evaluate the puta...


    pub_type: 杂志文章


    authors: Nagao S,Goto T,Kataoka S,Toyono T,Joujima T,Egusa H,Yatani H,Kobayashi S,Maki K

    更新日期:2014-12-01 00:00:00

  • Altered serum stress neuropeptide levels in critically ill individuals and associations with lymphocyte populations.

    abstract:OBJECTIVE:Potential physiological correlates of stress and the role of stress neuropeptides, other than those of the hypothalamic-pituitary-adrenal axis, in critical illness have not been addressed. We investigated: (a) serum levels of stress neuropeptides (ACTH, substance P (SP), neuropeptide Y (NPY), cortisol, prolac...


    pub_type: 杂志文章


    authors: Mpouzika MD,Papathanassoglou ED,Giannakopoulou M,Bozas E,Middleton N,Boti S,Patiraki EI,Karabinis A

    更新日期:2013-02-01 00:00:00

  • Effects of centrally-injected glucagon-like peptide-1 on pilocarpine-induced seizures, anxiety and locomotor and exploratory activity in rat.

    abstract::Glucagon-like peptide-1 (7-36)-amide (GLP-1) is a gut peptide, which exerts significant effects on glucose homeostasis. GLP-1 and GLP-1 receptors are also widely distributed in the central nervous system. In the present study, we aimed to investigate the effects of intracerebroventricularly (i.c.v.)-injected GLP-1 on ...


    pub_type: 杂志文章


    authors: Gulec G,Isbil-Buyukcoskun N,Kahveci N

    更新日期:2010-08-01 00:00:00

  • The role of enterostatin and apolipoprotein AIV on the control of food intake.

    abstract::Procolipase is secreted as a protein consisting of 101 amino acids. In the intestinal lumen, procolipase is activated by trypsin and cleaves to form the active colipase and the pentapeptide from the amino terminus. This pentapeptide is called enterostatin. Pancreatic procolipase synthesis is stimulated by a high-fat d...


    pub_type: 杂志文章,评审


    authors: Liu M,Shen L,Tso P

    更新日期:1999-10-01 00:00:00

  • Neuropeptide Y immunoreactivity and corticotropin-releasing hormone mRNA level are increased in the hypothalamus of mouse bearing a human oral squamous cell carcinoma.

    abstract::We examined gene expression of corticotropin-releasing hormone and neuropeptide Y level in the hypothalamic paraventricular nucleus of mouse bearing a human oral squamous cell carcinoma. A cell line derived from a human oral squamous cell carcinoma was inoculated into the lower dorsal area of nude mice. Body weight, t...


    pub_type: 杂志文章


    authors: Lee JH,Cha MJ,Choi SH,Hwang SJ,Kim DG,Jahng JW

    更新日期:2004-12-01 00:00:00

  • Regulation and effects of hypothalamic galanin: relation to dietary fat, alcohol ingestion, circulating lipids and energy homeostasis.

    abstract::Galanin (GAL) is known to stimulate feeding behavior. This peptide has different properties and functions from other feeding stimulants, e.g., neuropeptide Y and agouti-related protein. Hypothalamic GAL is relatively unresponsive to food deprivation and to changes in corticosterone, glucose utilization, dietary carboh...


    pub_type: 杂志文章,评审


    authors: Leibowitz SF

    更新日期:2005-06-01 00:00:00

  • Characterization of endoproteolytic processing of dynorphins by proprotein convertases using mouse spinal cord S9 fractions and mass spectrometry.

    abstract::Dynorphins are important neuropeptides with a central role in nociception and pain alleviation. Many mechanisms regulate endogenous dynorphin concentrations, including proteolysis. Proprotein convertases (PCs) are widely expressed in the central nervous system and specifically cleave at C-terminal of either a pair of ...


    pub_type: 杂志文章


    authors: Orduna AR,Beaudry F

    更新日期:2016-06-01 00:00:00

  • Enkephalin-like immunoreactivity in Drosophila melanogaster.

    abstract::Enkephalin-immunoreactive neurons have been identified in the central nervous system of the fruit fly Drosophila melanogaster by immunocytochemical techniques. Analyses of fly extracts by high performance liquid chromatography and radioimmunoassay show a relatively complex pattern of immunoreactive compounds. The most...


    pub_type: 杂志文章


    authors: Pagés M,Jiménez F,Ferrús A,Peralta E,Ramírez G,Gelpí E

    更新日期:1983-12-01 00:00:00

  • Characterization of beta-endorphin-immunoreactivity in limbic brain structures of rats self-administering heroin or cocaine.

    abstract::The effects of intravenous self-administration of 30 micrograms infusions of either heroin or cocaine, or saline on the concentrations of beta-endorphin-immunoreactivity (beta E-IR) in the anterior part of the rat brain limbic system were studied. Self-administration of heroin and cocaine for 5 daily sessions resulted...


    pub_type: 杂志文章


    authors: Sweep CG,Van Ree JM,Wiegant VM

    更新日期:1988-11-01 00:00:00

  • Buspirone and related compounds as alternative anxiolytics.

    abstract::The desire of the pharmaceutical industry to obtain more selective agents for the treatment of anxiety with fewer or diminished side effects and a profile consistent with safety during long-term use resulted in a search which has identified the azapirones as a new class of anxiolytics which lack structural or biochemi...


    pub_type: 临床试验,杂志文章,评审


    authors: Taylor DP,Moon SL

    更新日期:1991-07-01 00:00:00

  • beta-Endorphin in neuroblastoma x glioma hybrid cells.

    abstract::Acid extracts from mouse Neuroblastoma x rat Glioma hybrid cells have been purified by means of Sep-Pak C-18 and fractionated by high performance liquid chromatography. Each fraction has been submitted to a sensitive beta-endorphin radioimmunoassay and an immunoreactivity peak at camel beta-endorphin retention time wa...


    pub_type: 杂志文章


    authors: Di Marzo V,Etienne A,Marino G,Morris HR,Palmisano A

    更新日期:1985-03-01 00:00:00

  • Central neuropeptide FF reduces feed consumption and affects hypothalamic chemistry in chicks.

    abstract::Information on the physiological functions of neuropeptide FF; NPFF, a morphine modulating octapeptide in avians is lacking. Thus, we designed a study to investigate the effects of central NPFF with particular emphasis on appetite-related processes. Cobb-500 chicks were intracerebroventricularly (ICV) injected with 0,...


    pub_type: 杂志文章


    authors: Cline MA,Nandar W,Rogers JO

    更新日期:2007-12-01 00:00:00

  • Interaction of 125I-neuropeptide Y with rat cardiac membranes.

    abstract::125I-Neuropeptide Y (NPY) bound specifically with high affinity to rat atrial and ventricular membranes. Scatchard analysis revealed the presence of single class of binding sites in both atrial and ventricular membranes. The apparent Kd and Bmax for atrial membranes were 0.63 nM and 70 fmol/mg protein, respectively; v...


    pub_type: 杂志文章


    authors: Sheriff S,Rigel DF,Fischer JE,Balasubramaniam A

    更新日期:1990-03-01 00:00:00

  • Sulfhydryl reagents have different effects on substance P and neurokinin B binding sites on cortical synaptosomes in the rat.

    abstract::The effects of several protein modifying reagents, including phenoxybenzamine, N-ethylmaleimide (NEM), 5,5'-dithiobis (2-nitro)--benzoic acid (DTNB), p-chloromercuryphenyl sulfonic acid (PCMP) and p-bromophenacylbromide (PBPB), on the binding of 125I-Bolton Hunter substance P (125I-BHSP), 125I-Bolton Hunter eledoisin ...


    pub_type: 杂志文章


    authors: Bergström L,Beaujouan JC,Torrens Y,Saffroy M,Glowinski J

    更新日期:1987-02-01 00:00:00

  • Polymorphic variation as a driver of differential neuropeptide gene expression.

    abstract::The regulation of neuropeptide gene expression and their receptors in a tissue specific and stimulus inducible manner will determine in part behaviour and physiology. This can be a dynamic process resulting from short term changes in response to the environment or long term modulation imposed by epigenetically determi...


    pub_type: 杂志文章,评审


    authors: Quinn JP,Warburton A,Myers P,Savage AL,Bubb VJ

    更新日期:2013-12-01 00:00:00

  • Calcitonin gene related peptide in familial dysautonomia.

    abstract::Familial dysautonomia (FD) patients have diminished sensory C-fibers. Calcitonin gene related peptide (CGRP) is a widely distributed neuropeptide and prominent neurotransmitter in C-fibers. We show that plasma CGRP levels measured by radioimmunoassay is significantly lower in 51 FD patients compared to controls (P<0.0...


    pub_type: 杂志文章


    authors: Maayan C,Becker Y,Gesundheit B,Girgis SI

    更新日期:2001-06-01 00:00:00

  • Distribution of NPY receptors in the hypothalamus.

    abstract::Neuropeptide Y (NPY) neurons abundantly innervate the hypothalamus, where NPY is involved in the regulation and integration of a broad range of homeostatic functions. In order to understand NPY-mediated behavioral, autonomic and neuroendocrine effects, it is important to characterize in detail the distribution of the ...


    pub_type: 杂志文章,评审


    authors: Fetissov SO,Kopp J,Hökfelt T

    更新日期:2004-08-01 00:00:00