Abstract:
:Inoculation of rats at the tail-base with Mycobacterium led to arthritic swelling and inflammation of all four limbs. Immunoreactive (ir)-dynorphin (DYN) increased in anterior but not neurointermediate pituitary. In the brain, only thalamus showed a rise and, in spinal cord, a large elevation was seen. Ir-vasopressin (VP) was not affected in these tissues but increased in midbrain. These effects might reflect a role of DYN in the control of chronic pain. In addition, they support a differential modulation of DYN as compared to VP extrinsic to the hypothalamic-neurohypophyseal axis.
journal_name
Neuropeptidesjournal_title
Neuropeptidesauthors
Millan MJ,Millan MH,Pilcher CW,Colpaert FC,Herz Adoi
10.1016/0143-4179(85)90044-7subject
Has Abstractpub_date
1985-02-01 00:00:00pages
423-4issue
4-6eissn
0143-4179issn
1532-2785pii
0143-4179(85)90044-7journal_volume
5pub_type
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