Abstract：
:Neural stem cells (NSC) could promote the repair after spinal cord transection (SCT), the underlying mechanism, however, still keeps to be defined. This study reported that NSC grafts significantly improved sensory and locomotor functions in adult rats with SCT in acute stage after injury. NSC could survive; differentiate towards neurons or glia lineage in vitro and vivo. Biotin dextran amine (BDA) tracing showed that little CST regeneration in the injury site, while SEP was recorded in NSC engrafted rats. Immunohistochemistry and Real time PCR confirmed that engrafted NSC expressed BDNF and increased the level of BDNF mRNA in injured site following transplantation. The present data therefore suggested that the functional recovery following SCT with NSC transplantation was correlated with the expression of BDNF, indicating the usage of BDNF with NSC transplantation in the treatment of SCI following injury.
journal_name
Neuropeptidesjournal_title
Neuropeptidesauthors
He BL,Ba YC,Wang XY,Liu SJ,Liu GD,Ou S,Gu YL,Pan XH,Wang THdoi
10.1016/j.npep.2012.06.001subject
Has Abstractpub_date
2013-02-01 00:00:00pages
1-7issue
1eissn
0143-4179issn
1532-2785pii
S0143-4179(12)00054-6journal_volume
47pub_type
杂志文章相关文献
NEUROPEPTIDES文献大全abstract：:Nesfatin-1, a newly discovered satiety peptide, has recently been reported to be involved in the stress response. Stress-induced expression of nesfatin-1 has been reported and few studies focus on its expression in the hypothalamus, which is the center of the stress response. To test our hypothesis that peripheral and...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/j.npep.2015.08.003
更新日期：2015-12-01 00:00:00
abstract：:Glucagon-like peptide-1 (7-36)-amide (GLP-1) is a gut peptide, which exerts significant effects on glucose homeostasis. GLP-1 and GLP-1 receptors are also widely distributed in the central nervous system. In the present study, we aimed to investigate the effects of intracerebroventricularly (i.c.v.)-injected GLP-1 on ...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/j.npep.2010.02.002
更新日期：2010-08-01 00:00:00
abstract：:Pyroglutamyl peptidase I activity from soluble and membrane-bound fractions of rat brain homogenates is inhibited by the presence of sodium deoxycholate but not by triton X-100. Biobeads SM2, a polystyrene adsorbent reported to be useful in removing detergents from aqueous solutions, inhibits enzymatic activity in bot...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(95)90092-6
更新日期：1995-08-01 00:00:00
abstract：:Neuropeptide Y (NPY), Peptide YY (PYY) and pancreatic polypeptides (PPs) belong to the same peptide family called the Y or NPY family. Central and peripheral injections of these peptides are implicated in the regulation of food intake at the level of the hypothalamus (central effects; increased food intake) and dorsal...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/j.npep.2009.10.001
更新日期：2010-04-01 00:00:00
abstract：:Pituitary adenylate cyclase activating peptide and vasoactive intestinal peptide belong to the same neuropeptide family. Both peptides are present in nerve fibers in the gastric wall and are thought to be involved in the regulation of inflammatory processes. Experimental ulcers were induced in the rat gastric mucosa b...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/s0143-4179(98)90081-6
更新日期：1998-12-01 00:00:00
abstract：:In rat preprogalanin, galanin is C-terminally flanked by a 60 amino acid long peptide: galanin message-associated peptide (GMAP). GMAP sequences in different species show high degree of homology, suggesting a biological role. However, the study of the physiological and pharmacological actions of this peptide have been...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/s0143-4179(98)90037-3
更新日期：1998-04-01 00:00:00
abstract：:The desire of the pharmaceutical industry to obtain more selective agents for the treatment of anxiety with fewer or diminished side effects and a profile consistent with safety during long-term use resulted in a search which has identified the azapirones as a new class of anxiolytics which lack structural or biochemi...
journal_title：Neuropeptides
pub_type： 临床试验,杂志文章,评审
doi：10.1016/0143-4179(91)90078-w
更新日期：1991-07-01 00:00:00
abstract：:The Third Galanin Symposium presented many different and exciting results on galanin research reflecting a major progress since the previous symposium in 1998. A major impression was the many possible relationships of galaninergic mechanisms to important brain functions such as development, cognition and ageing as wel...
journal_title：Neuropeptides
pub_type：
doi：10.1016/j.npep.2005.03.002
更新日期：2005-06-01 00:00:00
abstract：:The effects of forskolin or phorbol-13-myristate (PMA) injected intrathecally (i.t.) or intracerebroventricularly (i.c.v.) on the inhibition of the tail-flick and hotplate responses induced by morphine or beta-endorphin administered i.c.v. were studied. Animals pretreated with forskolin (20 micrograms) i.t. for 10 min...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/s0143-4179(96)90085-2
更新日期：1996-04-01 00:00:00
abstract：:In equilibrium binding studies, using 3H-etorphine and 3H-diprenorphine, digitonin extracts of frog brain membranes are found to contain two classes of sites, one of which is seen only in the presence of Na+ ions. Centrifugation of the extracts in sucrose gradients separates two macromolecular components (10S and 12S)...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(84)90044-1
更新日期：1984-12-01 00:00:00
abstract：:The present study was undertaken to determine whether neurotensin is involved in the regulation of the intestinal postprandial motor response and, if so, whether the regulatory pathway depends upon peripheral or central neurotensin secretion. Neurotensin, injected by the i.v. route (5 micrograms/kg) during the fasting...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/s0143-4179(96)90002-5
更新日期：1996-10-01 00:00:00
abstract：:Alarin is a newly identified member of the galanin family of neuropeptides that includes galanin-like peptide (GALP) and galanin. Alarin was discovered as an alternate transcript of the GALP gene in neuroblastoma cells, and subsequently alarin mRNA was detected in the brain of rodents. GALP and galanin are important c...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/j.npep.2010.04.001
更新日期：2010-08-01 00:00:00
abstract：:Lumbar disc herniation is a common cause of radicular pain, but the mechanism remains ambiguous and the treatment stays unsatisfied. Many studies revealed a traditional Chinese medicine puerarin may moderate chronic pain from diabetes and nerve injury. Thus far, the role and mechanism of puerarin in radicular pain is ...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/j.npep.2018.10.001
更新日期：2018-12-01 00:00:00
abstract：:Release of [3H]-acetylcholine (3H-ACh) and muscle contractions in response to cholecystokinin (CCK) were measured and recorded simultaneously from isolated guinea-pig gallbladder. Cholecystokinin octapeptide (CCK8) (10(-10)-10(-7) M) enhanced the release of [3H]ACh and the contractions of the muscle. TTX (10(-6) M) in...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(93)90043-a
更新日期：1993-11-01 00:00:00
abstract：:Fracture repair is a complex yet well orchestrated regenerative process involving numerous signaling and cell types including osteoblasts. Here we showed that NPY, a neurotransmitter with regulatory functions in bone homeostasis, may contribute to the post-fracture bone healing in patients with traumatic brain injury-...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/j.npep.2016.09.005
更新日期：2016-12-01 00:00:00
abstract：:The regulation of neuropeptide gene expression and their receptors in a tissue specific and stimulus inducible manner will determine in part behaviour and physiology. This can be a dynamic process resulting from short term changes in response to the environment or long term modulation imposed by epigenetically determi...
journal_title：Neuropeptides
pub_type： 杂志文章,评审
doi：10.1016/j.npep.2013.10.003
更新日期：2013-12-01 00:00:00
abstract：:The effects of several mu and kappa opioid receptor agonists on urinary excretion were examined in the water-loaded rat. Mu agonists induced anti-diuresis whereas kappa agonists caused diuresis. Furthermore, high efficacy kappa agonists eg. U50, 488H and tifluadom, produced marked diuretic effects, whereas kappa parti...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(85)90047-2
更新日期：1985-02-01 00:00:00
abstract：:The neurokinin-1 (NK-1) receptor interacts with peptides that belong to the tachykinin family. NK-1 is inducible in bone marrow (BM) stroma. In neural cells, its expression is high to constitutive. Screening of three cDNA libraries indicated that this different in NK-1 expression in neural and BM cells could not be ex...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1054/npep.2002.0869
更新日期：2002-02-01 00:00:00
abstract：:Endothelins (ET) are a family of highly active neuropeptides with manifold influences via ET receptors (ETR) in both the peripheral and central nervous systems. We have shown previously that satellite glial cells (SGCs) in mouse trigeminal ganglia (TG) are extremely sensitive to ET-1 in evoking [Ca2+]in increase, appa...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/j.npep.2017.03.002
更新日期：2017-06-01 00:00:00
abstract：:Plasma protein extravasation in the upper airways of anesthetized guinea pigs was measured with the FITC (Fluorescein isothiocyanate)-dextran technique. The effect of selective tachykinin (NK1 and NK2) receptor agonists and antagonists, capsaicin or antigen was studied. The tachykinin NK1 receptor agonist, [Sar9]subst...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/s0143-4179(97)90022-6
更新日期：1997-02-01 00:00:00
abstract：:The effects of acute and chronic treatment with LSD and acute treatment with mescaline, m-CPP, citalopram and fenfluramine on leu-enkephalin (LENK) content in rat brain were examined. The acute LSD treatment was found to decrease and chronic treatment to increase the LENK content in the frontal cortex. In the thalamus...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(86)90028-4
更新日期：1986-05-01 00:00:00
abstract：:Utilizing a double-blind crossover design, the hormonal effects of high dose, 2 mg/kg, were compared to low dose, 0.4 mg (approx. 5 micrograms/kg), naloxone administration in physically healthy humans. A significant naloxone dose effect on plasma cortisol levels was found (p less than 0.001), but no significant effect...
journal_title：Neuropeptides
pub_type： 临床试验,杂志文章
doi：10.1016/0143-4179(85)90010-1
更新日期：1985-07-01 00:00:00
abstract：:Immunohistochemical tests have demonstrated for the first time the presence of endothelins in the neuroendocrine cells of fish gill. We have sought co-localization of endothelins with serotonin and neuropeptides which are regarded as neuroendocrine markers of pulmonary diffuse neuroendocrine systems in higher vertebra...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/s0143-4179(96)90055-4
更新日期：1996-02-01 00:00:00
abstract：:Dermorphin (Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH2), a naturally occurring peptide isolated from arboreal frog skin, is endowed with outstanding structural and biological features. It has no structural community with the sequence of mammalian opioid peptides and is a unique example of a D-aminoacid containing peptide which...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(89)90021-8
更新日期：1989-01-01 00:00:00
abstract：:Here we report that chicken pineal membranes express high affinity receptors for Vasoactive Intestinal Peptide (VIP), as revealed by competitive displacement analysis of [3-iodotyrosyl-125I]-VIP by native VIP. These binding sites were further characterized by covalent cross-linking of radioiodinated VIP to chicken pin...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(91)90066-r
更新日期：1991-05-01 00:00:00
abstract：:Clinical and experimental evidence have demonstrated that, use of alcohol during pregnancy can interrupt brain development. Alcohol-induced neurocognitive deficits in offspring's are involved with activation of oxidative-inflammatory cascade joined with extensive apoptotic neurodegeneration in different brain regions ...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/j.npep.2019.01.001
更新日期：2019-04-01 00:00:00
abstract：:Recent studies have shown that oxytocin reduces food intake and body weight gain and promotes lipolysis in some species, including humans. Interestingly, these effects of oxytocin are more marked in obese individuals. Although the menopausal loss of ovarian function induces increased visceral adiposity and some metabo...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/j.npep.2019.03.002
更新日期：2019-06-01 00:00:00
abstract：:The aim of the present investigation was to determine if chronic activation of kappa-opioid receptor induces development of tolerance and dependence to kappa-opioid agonists on the isolated right atrium of the rat. Tolerance to the kappa-agonist was induced by chronic administration of U-50,488H, a selective kappa-ago...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/s0143-4179(97)90047-0
更新日期：1997-10-01 00:00:00
abstract：:We have previously shown that the kappa-opioid agonist, asimadoline, produces time-dependent changes in neuropeptide concentrations in the joints of rats with chronic arthritis. We hypothesized that asimadoline acts on peripheral terminals to modulate substance P (SP) release. To address this hypothesis, here we have ...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1054/npep.2000.0813
更新日期：2000-06-01 00:00:00
abstract：:The action of corticotropin-releasing factor (CRF) is mediated by two recently identified receptors, CRFR1 and CRFR2, that differ with respect to their anatomical distribution and pharmacologic ligand-binding properties. Here we show by an analysis of circadian heartbeat interval fluctuations that CRFR2-deficiency in ...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/s0143-4179(02)00135-x
更新日期：2003-02-01 00:00:00
