Abstract:
:Glucagon-like peptide-1 (7-36)-amide (GLP-1) is a gut peptide, which exerts significant effects on glucose homeostasis. GLP-1 and GLP-1 receptors are also widely distributed in the central nervous system. In the present study, we aimed to investigate the effects of intracerebroventricularly (i.c.v.)-injected GLP-1 on pilocarpine-induced seizures, anxiety and locomotor and exploratory activity in rat. Rats were pretreated with GLP-1 (1-1000 ng/5 microl; i.c.v.) or saline (5 microl; i.c.v.) 30 min before seizure induction by pilocarpine (2.4 mg/5 microl; i.c.v.) and with GLP-1 (1, 10, 100 ng/5 microl; i.c.v.) or saline (5 microl; i.c.v.) 30 min before the open field test or the elevated plus maze test. GLP-1 did not produce any protective effect against pilocarpine-induced seizures and did not also produce statistically significant differences in the number of squares visited (measure of locomotor activity) or number of rearings (measure of exploratory behaviour), compared to the saline-treated rats in the open field test. On the other hand, GLP-1 (1 ng and 10 ng; i.c.v.) induced an anxiogenic effect, indicated by a decrease in the time spent in open arms, an increase in the time spent in closed arms, and a decrease in the anxiety scores in the elevated plus maze test. Pretreatment with an arginine vasopressin (AVP) V(1) receptor antagonist (125 ng/5 microl; i.c.v.) and L-NAME (100 microg/5 microl and 200 microg/5 microl) significantly abolished the anxiogenic effect of GLP-1 (1 ng/5 microl; i.c.v.). These results suggest that, centrally-injected GLP-1 produces anxiogenic effects via NO pathway and AVP V(1) receptors, but does not have any effects on pilocarpine-induced seizures or locomotor and exploratory activity in the open field test.
journal_name
Neuropeptidesjournal_title
Neuropeptidesauthors
Gulec G,Isbil-Buyukcoskun N,Kahveci Ndoi
10.1016/j.npep.2010.02.002subject
Has Abstractpub_date
2010-08-01 00:00:00pages
285-91issue
4eissn
0143-4179issn
1532-2785pii
S0143-4179(10)00026-0journal_volume
44pub_type
杂志文章相关文献
NEUROPEPTIDES文献大全abstract::The neuropeptide galanin is widely expressed in both the central and peripheral nervous systems. However there is limited understanding of how individual galanin receptor (GalR1, 2, and 3) subtypes mediate the physiological activity of galanin in vivo. To address this issue we utilized NAX-5055, a systemically availab...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2015.01.001
更新日期:2015-04-01 00:00:00
abstract:OBJECTIVES:Postmenopausal osteoporosis (PMO) is a metabolic skeletal disorder with impaired bone density and bone quality in postmenopausal women. The aim of the present study was to investigate the correlation between neuropeptides, bone microstructure and pain threshold in ovariectomized (OVX) rats. METHODS:Female r...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2019.101995
更新日期:2020-06-01 00:00:00
abstract::The action of corticotropin-releasing factor (CRF) is mediated by two recently identified receptors, CRFR1 and CRFR2, that differ with respect to their anatomical distribution and pharmacologic ligand-binding properties. Here we show by an analysis of circadian heartbeat interval fluctuations that CRFR2-deficiency in ...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/s0143-4179(02)00135-x
更新日期:2003-02-01 00:00:00
abstract::Neuromedin U (NMU), a neuropeptide implicated in feeding, inflammation, pain control and anxiety-related behaviours, is widely distributed in peripheral organs and the CNS. These effects are thought to be mediated by its receptors NMU(1) and NMU(2). Since its precise sites of interaction in the CNS were to date unknow...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2008.04.008
更新日期:2008-08-01 00:00:00
abstract::In vitro structure-activity studies with cholecystokinin (CCK)/gastrin-related peptides, including C- and N-terminal fragments of CCK 26-33, were undertaken in guinea pig gallbladder and ileum. The general order of potency in both smooth muscle preparations is CCK 26-33 greater than CCK 1-33 greater than 27-33 much mu...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(87)90084-9
更新日期:1987-07-01 00:00:00
abstract::Utilizing a double-blind crossover design, the hormonal effects of high dose, 2 mg/kg, were compared to low dose, 0.4 mg (approx. 5 micrograms/kg), naloxone administration in physically healthy humans. A significant naloxone dose effect on plasma cortisol levels was found (p less than 0.001), but no significant effect...
journal_title:Neuropeptides
pub_type: 临床试验,杂志文章
doi:10.1016/0143-4179(85)90010-1
更新日期:1985-07-01 00:00:00
abstract::The galanin family currently consists of four peptides, namely galanin, galanin-message associated peptide, galanin-like peptide and alarin. Unlike galanin that signals through three different G protein-coupled receptors; GAL1, GAL2, and GAL3, binding at its N-terminal end, the cognate receptors for other members of t...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2017.03.005
更新日期:2017-06-01 00:00:00
abstract::Specific antagonists were used to determine NK1 and NK2 receptor mediation of the expression of c-Jun and c-Fos inducible transcription factors. (ITFs) in dorsal horn neurons. The induction of c-Jun by C-fiber stimulation was strongly reduced in the superficial laminae by NK1 and NK2 antagonists, but only weakly in th...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1054/npep.1999.0005
更新日期:1999-04-01 00:00:00
abstract::Obesity is a global public health problem. Orexin and endocannabinoid signaling in the hypothalamus have been shown to regulate feeding and are promising molecular targets for obesity treatment. In this study, we attempted to analyze effects of orexin-A and endocannabinoid signaling modulation in the arcuate nucleus (...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2018.04.001
更新日期:2018-06-01 00:00:00
abstract::Release of [3H]-acetylcholine (3H-ACh) and muscle contractions in response to cholecystokinin (CCK) were measured and recorded simultaneously from isolated guinea-pig gallbladder. Cholecystokinin octapeptide (CCK8) (10(-10)-10(-7) M) enhanced the release of [3H]ACh and the contractions of the muscle. TTX (10(-6) M) in...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(93)90043-a
更新日期:1993-11-01 00:00:00
abstract::Dynorphins are important neuropeptides with a central role in nociception and pain alleviation. Many mechanisms regulate endogenous dynorphin concentrations, including proteolysis. Proprotein convertases (PCs) are widely expressed in the central nervous system and specifically cleave at C-terminal of either a pair of ...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2015.10.008
更新日期:2016-06-01 00:00:00
abstract::Various studies have shown a relationship between nerves and bones. Recent evidence suggests that both sensory and sympathetic nerves affect bone metabolism; however, little is known about how neuropeptides are involved in the differentiation of pluripotent stem cells into osteoblastic (OB) cells. To evaluate the puta...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2014.10.004
更新日期:2014-12-01 00:00:00
abstract::Neuropeptide Y (NPY) neurons abundantly innervate the hypothalamus, where NPY is involved in the regulation and integration of a broad range of homeostatic functions. In order to understand NPY-mediated behavioral, autonomic and neuroendocrine effects, it is important to characterize in detail the distribution of the ...
journal_title:Neuropeptides
pub_type: 杂志文章,评审
doi:10.1016/j.npep.2004.05.009
更新日期:2004-08-01 00:00:00
abstract::In previous studies, membranes from chicken gastrointestinal tissues failed to bind appreciable levels of 125I-APP labeled at the C-terminus. In order to address the suggestion that this was due to steric hindrance of the critical C-terminus, N-terminally labeled 125I-APP was utilized in in vitro membrane binding assa...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(92)90026-s
更新日期:1992-04-01 00:00:00
abstract::The desire of the pharmaceutical industry to obtain more selective agents for the treatment of anxiety with fewer or diminished side effects and a profile consistent with safety during long-term use resulted in a search which has identified the azapirones as a new class of anxiolytics which lack structural or biochemi...
journal_title:Neuropeptides
pub_type: 临床试验,杂志文章,评审
doi:10.1016/0143-4179(91)90078-w
更新日期:1991-07-01 00:00:00
abstract::Somatostatin, substance P, and vasoactive intestinal polypeptide were incubated in an adenylate cyclase assay with a particulate fraction of caudate-putamen tissue of the rat in order to examine the effect of the neuropeptides on G-protein coupled adenylate cyclase in vitro. Somatostatin induced an enhancement of cycl...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(92)90156-q
更新日期:1992-07-01 00:00:00
abstract::Nerve growth factor (NGF) was reported to be increased in the serum and skin of atopic dermatitis (AD) patients, to the extent that serum nerve growth factor levels were proposed to serve as a marker of disease severity. We studied NGF levels in the serum and dermis using skin microdialysis and attempted to correlate ...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2011.07.008
更新日期:2011-12-01 00:00:00
abstract::125I-Neuropeptide Y (NPY) bound specifically with high affinity to rat atrial and ventricular membranes. Scatchard analysis revealed the presence of single class of binding sites in both atrial and ventricular membranes. The apparent Kd and Bmax for atrial membranes were 0.63 nM and 70 fmol/mg protein, respectively; v...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(90)90148-r
更新日期:1990-03-01 00:00:00
abstract::Gestational cocaine treatment in rat dams results in decreased oxytocin (OT) levels, up-regulated oxytocin receptor (OTR) binding density and decreased receptor affinity in the whole amygdala, all concomitant with a significant increase in maternal aggression on postpartum day six. Rat dams with no gestational drug tr...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2006.03.002
更新日期:2006-06-01 00:00:00
abstract::Plasma levels of ghrelin, an orexigenic peptide, are increased during conditions of chronic starvation, such as in patients with anorexia nervosa. However, it is not known whether such increase can be related to the number of preproghrelin mRNA-expressing cells in the stomach, and if chronic starvation may activate a ...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2015.04.003
更新日期:2015-06-01 00:00:00
abstract::Amylin (AMY) is a member of calcitonin family of peptides. In this study, the effects of intrathecal (i.t) injection of AMY on the inflammatory pain and on the cAMP accumulation in the rat spinal cells were investigated. By using AMY receptor antagonists, we also studied the pharmacology of AMY receptors in the spinal...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2015.12.011
更新日期:2016-06-01 00:00:00
abstract::We have recently documented the expression of preprothyrotropin-releasing hormone (TRH) gene in murine, human and rat testis. Moreover, we have localized TRH to rat Leydig cells immunohistochemically, and found that both prepro TRH mRNA and TRH levels are developmentally regulated in the rat testis. To investigate the...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(94)90070-1
更新日期:1994-09-01 00:00:00
abstract::The selectivity of a series of opioid peptides towards the mu-, delta- and kappa-opioid receptors mediating differential inhibition of electrically-induced neurotransmitter release from rat brain slices was studied, viz. cortical [3H]noradrenaline release (inhibited via mu-receptors), striatal [3H]dopamine release (in...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(89)90065-6
更新日期:1989-08-01 00:00:00
abstract::Angiotensin I-converting enzyme (ACE) is recognized as one of the main effector molecules involved in blood pressure regulation. In the last few years some polymorphisms of ACE such as the insertion/deletion (I/D) polymorphism have been described, but their physiologic relevance is poorly understood. In addition, few ...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2009.12.003
更新日期:2010-04-01 00:00:00
abstract::Oxytocin, either intraperitoneally injected (200 ng/rat) or intracerebroventricularly infused (1 ng/rat in 4 microliters saline) 60 and 15 min respectively before testing, significantly increased the lordosis response to the mounting male of ovariectomized, estrogen/progesterone treated rats. The intracerebroventricul...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(85)90095-2
更新日期:1985-06-01 00:00:00
abstract::Down syndrome is the most common genetic disorder associated with mental retardation. Subjects and mice models for Down syndrome (such as Ts65Dn) show defects in the formation of neuronal networks in both the hippocampus and the cerebral cortex. The principal neurons display alterations in the morphology, density and ...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/j.npep.2011.10.002
更新日期:2012-02-01 00:00:00
abstract::6-Beta-fluoro-6-desoxy-oxymorphone (FOXY) is a fluorinated derivative of oxymorphone originally developed as a potential PET scanning ligand. Preliminary work (Rothman et al., Neuropeptides 4: 311-317, 1984) demonstrated that [3H]FOXY selectively labeled mu opioid binding sites with low levels of nonspecific binding. ...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(88)90020-0
更新日期:1988-01-01 00:00:00
abstract::Neuropeptide Y (NPY) -receptor subtypes were studied in the rat kidney in vivo by systemic administration of NPY, the two agonists [Leu(31), Pro(34)]NPY (Y1-receptor agonist) and NPY (13-36) (Y2-receptor agonist), or the Y1-receptor antagonist BIBP 3226. Effects on mean arterial blood pressure (MAP) and renal arterial...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1054/npep.1999.0755
更新日期:1999-08-01 00:00:00
abstract::Hippocampal neurogenesis is important for modulating the behavioural responses to stress and for certain forms of learning and memory. The mechanisms underlying the necessary coupling of neuronal activity to neural stem/progenitor cell (NSPC) function remain poorly understood. Within the dentate subgranular stem cell ...
journal_title:Neuropeptides
pub_type: 杂志文章,评审
doi:10.1016/j.npep.2013.10.002
更新日期:2013-12-01 00:00:00
abstract::Using the latency for tail-flick after thermal stimulation we have assessed the effects of alpha-, gamma(1)- and gamma(2)-MSH on nociceptive threshold in the mice. Intracisternal injections of gamma(2)-MSH induced a distinct analgesia, while gamma(1)-MSH in the same doses gave only a minor analgesia. Intracisternal al...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1054/npep.2000.0843
更新日期:2001-02-01 00:00:00