Abstract:
:125I-Neuropeptide Y (NPY) bound specifically with high affinity to rat atrial and ventricular membranes. Scatchard analysis revealed the presence of single class of binding sites in both atrial and ventricular membranes. The apparent Kd and Bmax for atrial membranes were 0.63 nM and 70 fmol/mg protein, respectively; ventricular membranes had an apparent kd of 0.39 nM and a Bmax of 283 fmol/mg protein. NPY structural homologues peptide YY (PYY) and pancreatic polypeptide (PP) bound to the ventricular membranes NPY receptor, but with several fold lower potency compared to NPY. Binding of 125I-NPY to ventricular membranes was sensitive to guanosine triphosphate (GTP) suggesting that the NPY receptor is linked to adenylate cyclase system. The receptor characterized in this system may play a crucial role in mediating the cardiac effects of NPY.
journal_name
Neuropeptidesjournal_title
Neuropeptidesauthors
Sheriff S,Rigel DF,Fischer JE,Balasubramaniam Adoi
10.1016/0143-4179(90)90148-rsubject
Has Abstractpub_date
1990-03-01 00:00:00pages
157-60issue
3eissn
0143-4179issn
1532-2785pii
0143-4179(90)90148-Rjournal_volume
15pub_type
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