Cocaine treatment alters oxytocin receptor binding but not mRNA production in postpartum rat dams.

abstract：:Male Wistar rats were injected intraperitoneally with chlorpromazine (2 or 10 mg/kg), haloperidol (0.5 or 2 mg/kg), sulpiride (50 or 100 mg/kg) or clozapine (10 or 25 mg/kg) once, for 14 or 28 consecutive days. Hypothalamic neuropeptide Y-like (NPY-like) immunoreactivity (NPY-LI) was determined 24 h after the last dos...

journal_title：Neuropeptides

authors： Obuchowicz E

更新日期：1996-10-01 00:00:00

abstract：:A human brain aminopeptidase, which hydrolyses low molecular weight enkephalin-containing peptides (ECPs), was purified to apparent homogeneity from the homogenate of human brain. The enzyme purification involved DEAE-cellulose chromatography and preparative polyacrylamide gel electrophoresis. The purified aminopeptid...

journal_title：Neuropeptides

authors： Duarte GI,Souza FG,Bruno JA,Camargo AC,Carvalho KM

更新日期：1988-08-01 00:00:00

abstract：:In rat preprogalanin, galanin is C-terminally flanked by a 60 amino acid long peptide: galanin message-associated peptide (GMAP). GMAP sequences in different species show high degree of homology, suggesting a biological role. However, the study of the physiological and pharmacological actions of this peptide have been...

journal_title：Neuropeptides

authors： Andell-Jonsson S,Bartfai T

更新日期：1998-04-01 00:00:00

abstract：:We have used immunohistochemistry and in situ hybridization histochemistry to visualize CGRP and the mRNA encoding the CGRP precursor in the stomach. CGRP is present in nerve fibers in the mucosa. CGRP mRNA and CGRP itself are also found in non-neural cells in the lamina propria. These cells are likely to be macrophag...

journal_title：Neuropeptides

authors： Jakab G,Webster HD,Salamon I,Mezey E

更新日期：1993-02-01 00:00:00

abstract：:Neuropeptide Y (NPY) neurons abundantly innervate the hypothalamus, where NPY is involved in the regulation and integration of a broad range of homeostatic functions. In order to understand NPY-mediated behavioral, autonomic and neuroendocrine effects, it is important to characterize in detail the distribution of the ...

journal_title：Neuropeptides

authors： Fetissov SO,Kopp J,Hökfelt T

更新日期：2004-08-01 00:00:00

abstract：:Previous behavioural and electrophysiological studies have indicated an antinarcotic action of thyrotropin-releasing hormone (TRH) and its analogues in antagonizing the action of CNS depressant drugs, including baclofen and a variety of anesthetics. While beta-adrenergic receptors are implicated in the level of anaest...

journal_title：Neuropeptides

authors： Clarke KA,Djouhri L

更新日期：1991-09-01 00:00:00

abstract：:The effect of the selective non-peptide antagonist for NK1 receptors (+/-)CP 96,345 on cellular transduction mechanisms elicited by the NK1 selective agonist [Sar9]-substance P-sulfone ([Sar9]-SP) was investigated in a stabilized culture of human skin fibroblasts (HF) and compared to the effects of two peptide antagon...

journal_title：Neuropeptides

authors： Ziche M,Parenti A,Amerini S,Zawieja D,Maggi CA,Ledda F

更新日期：1996-08-01 00:00:00

abstract：:Rat/mouse hemokinin-1 (r/m HK-1) has been identified as a member of the tachykinin family and its effect in colonic contractile activity remains unknown. We investigated the effects and mechanisms of actions of r/m HK-1 on the mouse colonic contractile activity in vitro by comparing it with that of substance P (SP). R...

journal_title：Neuropeptides

authors： Kong ZQ,Han M,Yang WL,Zhao YL,Fu CY,Tao Y,Chen Q,Wang R

更新日期：2009-06-01 00:00:00

abstract：:Humanin (HN) is an endogenous 24-residue peptide. A highly potent HN derivative, S14G-HN, which has a substitution of serine 14 to glycine, reduced amyloid burden and suppressed cognitive impairment in a mouse model of Alzheimer's disease. S14G-HN also suppressed amnesia induced by a muscarinic receptor antagonist in ...

journal_title：Neuropeptides

authors： Murakami M,Nagahama M,Maruyama T,Niikura T

更新日期：2017-04-01 00:00:00

abstract：:The effects of forskolin or phorbol-13-myristate (PMA) injected intrathecally (i.t.) or intracerebroventricularly (i.c.v.) on the inhibition of the tail-flick and hotplate responses induced by morphine or beta-endorphin administered i.c.v. were studied. Animals pretreated with forskolin (20 micrograms) i.t. for 10 min...

journal_title：Neuropeptides

authors： Suh HW,Song DK,Sim YB,Chung KM,Kim YH

更新日期：1996-04-01 00:00:00

abstract：:Galanin and the N-terminal fragment Galanin(1-15) are involved in central cardiovascular regulation. The present paper reviews the recent cardiovascular results obtained by intracisternal injections of Galanin and Galanin(1-15) showing that: (A) the Galanin antagonist M40 blocks the central cardiovascular responses in...

journal_title：Neuropeptides

authors： Díaz-Cabiale Z,Parrado C,Vela C,Razani H,Coveñas R,Fuxe K,Narváez JA

更新日期：2005-06-01 00:00:00

abstract：:Neuropeptide Y (NPY) causes anxiolytic- and antidepressant-like effects after central administration in rodents. These effects could theoretically be utilized in future gene therapy for anxiety and depression using viral vectors for induction of overexpression of NPY in specific brain regions. Using a recombinant aden...

journal_title：Neuropeptides

authors： Christiansen SH,Olesen MV,Gøtzsche CR,Woldbye DP

更新日期：2014-12-01 00:00:00

abstract：:Oxytocin (OXT), a nonapeptide hormone of posterior pituitary, reaches the central nervous system from systemic blood circulation with a difficulty because of the blood-brain barrier (BBB). The interest has been expressed in the use of the nasal route for delivery of OXT to the brain directly, exploiting the olfactory ...

journal_title：Neuropeptides

authors： Wang YL,Yuan Y,Yang J,Wang CH,Pan YJ,Lu L,Wu YQ,Wang DX,Lv LX,Li RR,Xue L,Wang XH,Bi JW,Liu XF,Qian YN,Deng ZK,Zhang ZJ,Zhai XH,Zhou XJ,Wang GL,Zhai JX,Liu WY

更新日期：2013-04-01 00:00:00

abstract：:Chronic stress induces the activation of hippocampal microglia, which produces many inflammatory mediators and mediates the occurrence of depression. Two phenotypes of microglia polarization, the classical M1 and alternative M2, play important regulatory roles in neuroinflammation and are involved in the occurrence an...

journal_title：Neuropeptides

authors： Zhou S,Chen S,Xie W,Guo X,Zhao J

更新日期：2020-06-01 00:00:00

abstract：:Prader-Willi syndrome (PWS) is the predominant genetic cause of obesity in humans and is associated with several behavioural phenotypes such as altered motoric function, reduced activity, and learning disabilities. It can include mood instability and, in some cases, psychotic episodes. Recently, the Snord116 gene has ...

journal_title：Neuropeptides

authors： Zieba J,Low JK,Purtell L,Qi Y,Campbell L,Herzog H,Karl T

更新日期：2015-10-01 00:00:00

abstract：:We have recently documented the expression of preprothyrotropin-releasing hormone (TRH) gene in murine, human and rat testis. Moreover, we have localized TRH to rat Leydig cells immunohistochemically, and found that both prepro TRH mRNA and TRH levels are developmentally regulated in the rat testis. To investigate the...

journal_title：Neuropeptides

authors： Satoh T,Feng P,Kim UJ,Wilber JF

更新日期：1994-09-01 00:00:00

abstract：OBJECTIVE:Potential physiological correlates of stress and the role of stress neuropeptides, other than those of the hypothalamic-pituitary-adrenal axis, in critical illness have not been addressed. We investigated: (a) serum levels of stress neuropeptides (ACTH, substance P (SP), neuropeptide Y (NPY), cortisol, prolac...

journal_title：Neuropeptides

authors： Mpouzika MD,Papathanassoglou ED,Giannakopoulou M,Bozas E,Middleton N,Boti S,Patiraki EI,Karabinis A

更新日期：2013-02-01 00:00:00

abstract：:Several lines of evidence indicate a role for neuropeptide Y (NPY) in the modulation of the corticotroph axis. In two separate studies reported here, the concentrations of NPY and noradrenaline (NA), as well as corticotropin-releasing factor (CRF) and arginine vasopressin (AVP), were measured in extracts of individual...

journal_title：Neuropeptides

authors： Pralong FP,Corder R,Gaillard RC

更新日期：1993-10-01 00:00:00

abstract：RATIONALE:Cholecystokinin and its analogs generate anxiety in humans and measurable anxiety-like behaviors in rats. Cholecystokinin receptor blockers have been reported to have variable effects in the treatment of anxiety disorders. We demonstrated that intracerebroventricular administration of Cholecystokinin-antisens...

journal_title：Neuropeptides

authors： Cohen H,Matar MA,Buriakovsky I,Zeev K,Kotler M,Bourin M

更新日期：2002-10-01 00:00:00

abstract：:Alarin is a newly identified member of the galanin family of neuropeptides that includes galanin-like peptide (GALP) and galanin. Alarin was discovered as an alternate transcript of the GALP gene in neuroblastoma cells, and subsequently alarin mRNA was detected in the brain of rodents. GALP and galanin are important c...

journal_title：Neuropeptides

authors： Van Der Kolk N,Madison FN,Mohr M,Eberhard N,Kofler B,Fraley GS

更新日期：2010-08-01 00:00:00

abstract：:Nesfatin-1, a newly discovered satiety peptide, has recently been reported to be involved in the stress response. Stress-induced expression of nesfatin-1 has been reported and few studies focus on its expression in the hypothalamus, which is the center of the stress response. To test our hypothesis that peripheral and...

journal_title：Neuropeptides

authors： Xu YY,Ge JF,Qin G,Peng YN,Zhang CF,Liu XR,Liang LC,Wang ZZ,Chen FH,Li J

更新日期：2015-12-01 00:00:00

abstract：:Levels of beta-endorphin immunoreactive material (IRM) in cerebrospinal fluid (CSF) have been reported to correlate inversely with postoperative morphine requirement. Considering proopiomelanocortin (POMC) derivatives as predictors for sensitivity to postoperative pain, we determined authentic beta-endorphin (beta-end...

journal_title：Neuropeptides

authors： Matejec R,Schulz A,Mühling J,Uhlich H,Bödeker RH,Hempelmann G,Teschemacher H

更新日期：2006-02-01 00:00:00

abstract：:Abnormal aggregation of beta-amyloid (Aβ) peptide into amyloid plaques in the brain has been identified as one of the key factors in instigating AD pathogenesis. Inhibition of Aβ aggregation can be an important therapeutic strategy in disease management. In this work, we demonstrate the application of structure-based ...

journal_title：Neuropeptides

authors： Pandey G,Morla S,Kumar S,Ramakrishnan V

更新日期：2020-06-01 00:00:00

abstract：:Cholecystokinin (CCK) is a widely expressed neuropeptide system originally discovered in the gut. Both cerebral and peripheral neurons as well as endocrine I-cells in the small intestine process proCCK to tyrosyl-O-sulfated and α-carboxyamidated peptides. Recently, we reported that gut endocrine I-cells also synthetiz...

journal_title：Neuropeptides

authors： Agersnap M,Zhang MD,Harkany T,Hökfelt T,Rehfeld JF

更新日期：2016-12-01 00:00:00

abstract：:AtT-20 cells are known to synthesize two molecular weight forms of the prohormone converting enzyme PC1 with molecular masses of 87 and 66 kDa. In this study we have analyzed basal and stimulated secretion of these proteins. Western blot results show that basal secretion medium of cultured AtT-20 cells contained low c...

journal_title：Neuropeptides

authors： Vindrola O,Lindberg I

更新日期：1993-08-01 00:00:00

abstract：:Exercise at different intensities is able to induce different physical and psychological statuses of the subjects. The β-endorphin (β-EP) in central nervous system is thought to play an important role in physical exercise. However, its expression patterns and physiological effects in the central nuclei under different...

journal_title：Neuropeptides

authors： Xue L,Sun J,Zhu J,Ding Y,Chen S,Ding M,Pei H

更新日期：2020-08-01 00:00:00

abstract：:Injection of endothelin-1 (9 pmol) into the lateral cerebral ventricle of rats produced barrel-rotations, convulsions, tonic hindlimb extensions, facial clonus, and kinetic ataxia for up to 45 min. Quantitative metabolic autoradiographs produced from the [14C]deoxyglucose method and analyzed over 60 individual brain s...

journal_title：Neuropeptides

authors： Gross PM,Wainman DS,Espinosa FJ,Nag S,Weaver DF

更新日期：1992-04-01 00:00:00

abstract：:Proenkephalin peptides produced by endocrine and nervous tissues are involved in stress-induced immunosuppression. However, the role of peptides produced by immune cells remains unknown. The present study examines the effect of acute and chronic foot-shock stress on proenkephalin peptide content in bone marrow (BMMC),...

journal_title：Neuropeptides

authors： Saravia F,Padros MR,Ase A,Aloyz R,Duran S,Vindrola O

更新日期：1998-08-01 00:00:00

abstract：:A series of analogues of substance P, where the Met11 residue was replaced by Glu(OCH2CH3), Glu(OBzl) and Hse(CH3), were synthesized in order to investigate the effect on agonist activity of modifications at the C-terminal residue. The biological activities in the guinea-pig ileum assay (NK1 receptor) and rat [text sa...

journal_title：Neuropeptides

authors： Poulos C,Antoniou M,Patacchini R,Maggi CA,Pegoraro S,Rovero P

更新日期：1994-07-01 00:00:00

abstract：:Neuromedin U (NMU), a neuropeptide implicated in feeding, inflammation, pain control and anxiety-related behaviours, is widely distributed in peripheral organs and the CNS. These effects are thought to be mediated by its receptors NMU(1) and NMU(2). Since its precise sites of interaction in the CNS were to date unknow...

journal_title：Neuropeptides

authors： Mangold C,Ksiazek I,Yun SW,Berger E,Binkert C

更新日期：2008-08-01 00:00:00