Structure-activity studies of C- and N-terminal fragments of cholecystokinin 26-33 in guinea pig isolated tissues.

abstract：:Immune system function has been shown to be under the influence of various neuromodulators and endocrine system peptides. This in vitro study describes the stimulatory effect of thyrotropin releasing hormone (thyroliberin, TRH) on thyrotropin (TSH) release from cultured human peripheral blood monocytes. The stimulator...

journal_title：Neuropeptides

authors： Komorowski J,Stepień H,Pawlikowski M

更新日期：1993-07-01 00:00:00

abstract：:The role played by the biologically active CART 55-102 peptide in NAcc AMPH induced locomotion was investigated. When microinjected alone into this site, none of the doses of CART 55-102 tested (0.1, 0.4, 1.0 or 2.5 microg/0.5 microl/side) produced effects on locomotion during a two-h test. However, when co-injected w...

journal_title：Neuropeptides

authors： Kim JH,Creekmore E,Vezina P

更新日期：2003-12-01 00:00:00

abstract：:Tachykinins are a family of pronociceptive neuropeptides with a specific role in pain and inflammation. Several mechanisms regulate endogenous tachykinins and Substance P (SP) levels, including the differential expression of protachykinin mRNA and the controlled secretion of tachykinins from neurons. Proteolysis is su...

journal_title：Neuropeptides

authors： Saidi M,Kamali S,Beaudry F

更新日期：2016-10-01 00:00:00

abstract：:Several studies suggest that prenatal ethanol exposure (PEE) facilitates ethanol intake. Opioid peptides play a main role in ethanol reinforcement during infancy and adulthood. However, PEE effects upon motor responsiveness elicited by an ethanol challenge and the participation of opioids in these actions remain to be...

journal_title：Neuropeptides

authors： Abate P,Reyes-Guzmán AC,Hernández-Fonseca K,Méndez M

更新日期：2017-04-01 00:00:00

abstract：:We have described the binding of [125I]endothelin-1 (ET-1) to cultured rat cerebellar granule cells. Binding of [125I]ET-1 was specific, saturable, and time-dependent. Scatchard analysis of saturation binding data indicated a single class of high affinity binding site with a KD of 95 pM, and a Bmax of 8110 receptors/c...

journal_title：Neuropeptides

authors： Lysko PG,Feuerstein G,Pullen M,Wu HL,Nambi P

更新日期：1991-02-01 00:00:00

abstract：:The regulation of neuropeptide gene expression and their receptors in a tissue specific and stimulus inducible manner will determine in part behaviour and physiology. This can be a dynamic process resulting from short term changes in response to the environment or long term modulation imposed by epigenetically determi...

journal_title：Neuropeptides

authors： Quinn JP,Warburton A,Myers P,Savage AL,Bubb VJ

更新日期：2013-12-01 00:00:00

abstract：:In previous studies, membranes from chicken gastrointestinal tissues failed to bind appreciable levels of 125I-APP labeled at the C-terminus. In order to address the suggestion that this was due to steric hindrance of the critical C-terminus, N-terminally labeled 125I-APP was utilized in in vitro membrane binding assa...

journal_title：Neuropeptides

authors： Adamo ML,Hazelwood RL

更新日期：1992-04-01 00:00:00

abstract：:The recent surge of scientific interest in 5-hydroxytryptamine3 (5-HT3) receptors can be attributed largely to the rapid increase in the number of potent and selective 5-HT3 receptor antagonists. The availability of a large variety of chemically diverse 5-HT3 compounds allows for a unique opportunity to apply computer...

journal_title：Neuropeptides

authors： Peroutka SJ

更新日期：1991-07-01 00:00:00

abstract：:Pyroglutamyl peptidase I activity from soluble and membrane-bound fractions of rat brain homogenates is inhibited by the presence of sodium deoxycholate but not by triton X-100. Biobeads SM2, a polystyrene adsorbent reported to be useful in removing detergents from aqueous solutions, inhibits enzymatic activity in bot...

journal_title：Neuropeptides

authors： Alba F,Arenas JC,Lopez MA

更新日期：1995-08-01 00:00:00

abstract：:Angiotensin I-converting enzyme (ACE) is recognized as one of the main effector molecules involved in blood pressure regulation. In the last few years some polymorphisms of ACE such as the insertion/deletion (I/D) polymorphism have been described, but their physiologic relevance is poorly understood. In addition, few ...

journal_title：Neuropeptides

authors： Almeida SS,Barros CC,Moraes MR,Russo FJ,Haro AS,Rosa TS,Alves MF,Pesquero JB,Carmona AK,Bacurau RF,Araújo RC

更新日期：2010-04-01 00:00:00

abstract：:The effect of opioid peptide, D-alanine2-leucine-enkephalin and opioid homolog peptide, des-tyrosine-methionine-enkephalin in concentrations of 1 x 10(-6) and 1 x 10(-5) M was investigated on the action potential parameters of frog sciatic nerve. Des-tyrosine-methionine-enkephalin was used as the control to prove the ...

journal_title：Neuropeptides

authors： Camlica Y,Aşkin A,Cömelekoğlu U

更新日期：2004-04-01 00:00:00

abstract：:During neonatal development exogenous oxytocin increases ERalpha immunoreactivity in the hypothalamus of female prairie voles. The purpose of this study was to determine if the increase in ERalpha is associated with an increase in ERalpha mRNA expression and to determine if the effect is specific to ER subtype or if o...

journal_title：Neuropeptides

authors： Pournajafi-Nazarloo H,Carr MS,Papademeteriou E,Schmidt JV,Cushing BS

更新日期：2007-02-01 00:00:00

abstract：:Stretching-yawning syndrome (SYS) and penile erections (PE) are typical components of the behavioral picture induced by intracerebroventricular (i.c.v.) injection of ACTH 1-24. The present study shows that pretreatment with alpha-difluoromethylornithine (DFMO), and irreversible inhibitor of mammalian ornithine decarbo...

journal_title：Neuropeptides

authors： Genedani S,Bernardi M,Bertolini A

更新日期：1984-05-01 00:00:00

abstract：:Clinical and experimental evidence have demonstrated that, use of alcohol during pregnancy can interrupt brain development. Alcohol-induced neurocognitive deficits in offspring's are involved with activation of oxidative-inflammatory cascade joined with extensive apoptotic neurodegeneration in different brain regions ...

journal_title：Neuropeptides

authors： Toosi A,Shajiee H,Khaksari M,Vaezi G,Hojati V

更新日期：2019-04-01 00:00:00

abstract：:Melanin-concentrating hormone (MCH) and dynorphin genes are expressed in two discrete neuron populations of the rat lateral hypothalamus. Their roles remain hypothetical in mammals. In order to analyse changes in MCH and dynorphin gene expression, a multiplex competitive semi-quantitative reverse transcription-polymer...

journal_title：Neuropeptides

authors： Hervé C,Fellmann D

更新日期：1997-06-01 00:00:00

abstract：:Pituitary adenylate cyclase-activating polypeptide (PACAP-27) was incubated in a tyrosine hydroxylase (TyrOH) assay with a homogenate preparation of the nucleus accumbens of the rat. TyrOH activity was determined in vitro by measuring the production of L-dopa with HPLC-ECD. Only in the presence of adenosine nucleotide...

journal_title：Neuropeptides

authors： Moser A,Scholz J,Gänsle A

更新日期：1999-12-01 00:00:00

abstract：:The galanin family currently consists of four peptides, namely galanin, galanin-message associated peptide, galanin-like peptide and alarin. Unlike galanin that signals through three different G protein-coupled receptors; GAL1, GAL2, and GAL3, binding at its N-terminal end, the cognate receptors for other members of t...

journal_title：Neuropeptides

authors： Ihnatko R,Theodorsson E

更新日期：2017-06-01 00:00:00

abstract：:Orexins are neuropeptides that are localized to neurons in the lateral and dorsal hypothalamus but its receptors are distributed to many different regions of the central nervous system. Orexins are implicated in a variety of physiological functions including sleep regulation, energy homeostats, and stress reactions. F...

journal_title：Neuropeptides

authors： Toyama S,Shimoyama N,Shimoyama M

更新日期：2017-02-01 00:00:00

abstract：:We examined the effects of gestational cocaine treatment on oxytocin levels in the whole hippocampus (HIP), ventral tegmental area (VTA), medial preoptic area (MPOA) and amygdala (AMY) in rat dams on postpartum days (PPDs) 1 and 2. Cocaine treatment significantly reduced oxytocin levels in the MPOA within 12-16 h of d...

journal_title：Neuropeptides

authors： Johns JM,Lubin DA,Walker CH,Meter KE,Mason GA

更新日期：1997-10-01 00:00:00

abstract：:Fracture repair is a complex yet well orchestrated regenerative process involving numerous signaling and cell types including osteoblasts. Here we showed that NPY, a neurotransmitter with regulatory functions in bone homeostasis, may contribute to the post-fracture bone healing in patients with traumatic brain injury-...

journal_title：Neuropeptides

authors： Gu XC,Zhang XB,Hu B,Zi Y,Li M

更新日期：2016-12-01 00:00:00

abstract：:The present study was planned to evaluate role of tachykinins (TKs) and neurokinin (NK) receptors in the regulation of gastric motility in sheep. We examined the effects of intravenous (i.v.) injection of neurokinin A (NKA) and substance P (SP) on motility of the rumen, omasum, and abomasum in conscious sheep and the ...

journal_title：Neuropeptides

authors： Oh-ishi T,Shimoda T,Hayashi H,Onaga T

更新日期：2013-02-01 00:00:00

abstract：:HPLC techniques were used to identify peptides that possess vasopressin-like immunoreactivity in the chicken neurohypophysis. The presence of arginine vasotocin (AVT) was confirmed together with arginine vasopressin (AVP). That the presence of AVP may be confined to the chicken, and not other avian species, was conclu...

journal_title：Neuropeptides

authors： Choy VJ,Watkins WB

更新日期：1986-08-01 00:00:00

abstract：:Neuropeptide Y (NPY), Peptide YY (PYY) and pancreatic polypeptides (PPs) belong to the same peptide family called the Y or NPY family. Central and peripheral injections of these peptides are implicated in the regulation of food intake at the level of the hypothalamus (central effects; increased food intake) and dorsal...

journal_title：Neuropeptides

authors： Mahaut S,Dumont Y,Fournier A,Quirion R,Moyse E

更新日期：2010-04-01 00:00:00

abstract：:PTHrP and its receptor PTHR1 are found in the CNS and peripheral nervous system. The presence of PTHrP mRNA has been detected in the superior cervical ganglion (SCG), but there are no data on the cellular distribution of PTHrP and PTHR1 in the SCG. Although it is known that ovarian activity and reproductive status inf...

journal_title：Neuropeptides

authors： Filipović N,Vrdoljak M,Vuica A,Jerić M,Jeličić Kadić A,Utrobičić T,Mašek T,Grković I

更新日期：2014-12-01 00:00:00

abstract：:Specific antagonists were used to determine NK1 and NK2 receptor mediation of the expression of c-Jun and c-Fos inducible transcription factors. (ITFs) in dorsal horn neurons. The induction of c-Jun by C-fiber stimulation was strongly reduced in the superficial laminae by NK1 and NK2 antagonists, but only weakly in th...

journal_title：Neuropeptides

authors： Redburn JL,Leah JD

更新日期：1999-04-01 00:00:00

abstract：:In critical patients, sepsis-induced muscle wasting is considered to be an important contributor to complications and mortality. Previous work mainly focuses on the peripheral molecular mechanism of muscle degradation, however little evidence exists for the role of central nervous system in the process. In the present...

journal_title：Neuropeptides

authors： Duan K,Yu W,Lin Z,Tan S,Bai X,Gao T,Xi F,Li N

更新日期：2014-12-01 00:00:00

abstract：:The antinociceptive effect of intrathecally (i.t.) administered protease inhibitors was tested against capsaicin (800 ng) injected into the dorsal surface of a hindpaw. Both p-hydroxymercuribenzoate (2-8 nmol), a cysteine protease inhibitor, and phosphoramidon (1-4 nmol), an endopeptidase 24.11 inhibitor in the presen...

journal_title：Neuropeptides

authors： Tan-No K,Taira A,Inoue M,Ohshima K,Sakurada T,Sakurada C,Nylander I,Demuth HU,Silberring J,Terenius L,Tadano T,Kisara K

更新日期：1998-10-01 00:00:00

abstract：:In rat preprogalanin, galanin is C-terminally flanked by a 60 amino acid long peptide: galanin message-associated peptide (GMAP). GMAP sequences in different species show high degree of homology, suggesting a biological role. However, the study of the physiological and pharmacological actions of this peptide have been...

journal_title：Neuropeptides

authors： Andell-Jonsson S,Bartfai T

更新日期：1998-04-01 00:00:00

abstract：:We have assessed the influence of acute bilateral nephrectomy, of captopril and saralasin, on the hypotensive activity of neurotensin (NT) and of various hypotensive drugs in pentobarbital-anesthetized rats. The results show that the hypotensive activity of NT and of compound 48/80 (C48/80), in contrast to that of his...

journal_title：Neuropeptides

authors： Kérouac R,St-Pierre S,Manning M,Rioux F

更新日期：1983-04-01 00:00:00

abstract：:Utilizing a double-blind crossover design, the hormonal effects of high dose, 2 mg/kg, were compared to low dose, 0.4 mg (approx. 5 micrograms/kg), naloxone administration in physically healthy humans. A significant naloxone dose effect on plasma cortisol levels was found (p less than 0.001), but no significant effect...

journal_title：Neuropeptides

authors： Cohen MR,Cohen RM,Pickar D,Kreger D,McLellan C,Murphy DL

更新日期：1985-07-01 00:00:00