Intrathecal administration of p-hydroxymercuribenzoate or phosphoramidon/bestatin-combined induces antinociceptive effects through different opioid mechanisms.

abstract：:125I-Neuropeptide Y (NPY) bound specifically with high affinity to rat atrial and ventricular membranes. Scatchard analysis revealed the presence of single class of binding sites in both atrial and ventricular membranes. The apparent Kd and Bmax for atrial membranes were 0.63 nM and 70 fmol/mg protein, respectively; v...

journal_title：Neuropeptides

authors： Sheriff S,Rigel DF,Fischer JE,Balasubramaniam A

更新日期：1990-03-01 00:00:00

abstract：:Microchemotaxis chambers were used to investigate whether one aspect of ciliary neurotrophic factor CNTF's role as a lesion factor might be to promote the initial early recruitment of macrophages, which express the signal transducing receptor components, gp130 and LIFRbeta. CNTFRalpha alone, or in combination with CNT...

journal_title：Neuropeptides

authors： Kobayashi H,Mizisin AP

更新日期：2000-12-01 00:00:00

abstract：:PTHrP and its receptor PTHR1 are found in the CNS and peripheral nervous system. The presence of PTHrP mRNA has been detected in the superior cervical ganglion (SCG), but there are no data on the cellular distribution of PTHrP and PTHR1 in the SCG. Although it is known that ovarian activity and reproductive status inf...

journal_title：Neuropeptides

authors： Filipović N,Vrdoljak M,Vuica A,Jerić M,Jeličić Kadić A,Utrobičić T,Mašek T,Grković I

更新日期：2014-12-01 00:00:00

abstract：:Glucocorticoid deficiency is associated with a decrease of food intake. Orexigenic peptides, neuropeptide Y (NPY) and agouti related protein (AgRP), and the anorexigenic peptide proopiomelanocortin (POMC), expressed in the arcuate nucleus of the hypothalamus (ARC), are regulated by meal-induced signals. Orexigenic neu...

journal_title：Neuropeptides

authors： Uchoa ET,Silva LE,de Castro M,Antunes-Rodrigues J,Elias LL

更新日期：2012-06-01 00:00:00

abstract：:There is now considerable evidence that putative neuropeptides are involved in epileptogenic processes. Neurotensin (NT), which affects neuronal excitability in many parts of the CNS, is potentially relevant to the kindling phenomenon, but has not previously been studied in the kindling model of epilepsy. This study c...

journal_title：Neuropeptides

authors： Shulkes A,Harris QL,Lewis SJ,Vajda JE,Jarrott B

更新日期：1988-02-01 00:00:00

abstract：:Noradrenaline (NA) has been implicated in both increase and reduction of anxiety. Selective destruction of nerve endings of the locus coeruleus projections by DSP-4 has been shown to reduce active behaviour in novel situations by enhancing anxiety. In the present study, DSP-4 (50 mg/kg) treatment reduced locomotor act...

journal_title：Neuropeptides

authors： Kask A,Eller M,Oreland L,Harro J

更新日期：2000-02-01 00:00:00

abstract：:The effects of several protein modifying reagents, including phenoxybenzamine, N-ethylmaleimide (NEM), 5,5'-dithiobis (2-nitro)--benzoic acid (DTNB), p-chloromercuryphenyl sulfonic acid (PCMP) and p-bromophenacylbromide (PBPB), on the binding of 125I-Bolton Hunter substance P (125I-BHSP), 125I-Bolton Hunter eledoisin ...

journal_title：Neuropeptides

authors： Bergström L,Beaujouan JC,Torrens Y,Saffroy M,Glowinski J

更新日期：1987-02-01 00:00:00

abstract：:There is now unequivocal evidence that the angiotensin-converting enzyme 2(ACE2)-Ang-(1-7)-Mas axis is a key component of the renin-angiotensin system (RAS) cascade, which is closely correlated with ischemic insult occurrence. Our previous studies demonstrated that the Ang-(1-7), was an active member of the brain RAS....

journal_title：Neuropeptides

authors： Lu J,Jiang T,Wu L,Gao L,Wang Y,Zhou F,Zhang S,Zhang Y

更新日期：2013-10-01 00:00:00

abstract：:The present study was planned to evaluate role of tachykinins (TKs) and neurokinin (NK) receptors in the regulation of gastric motility in sheep. We examined the effects of intravenous (i.v.) injection of neurokinin A (NKA) and substance P (SP) on motility of the rumen, omasum, and abomasum in conscious sheep and the ...

journal_title：Neuropeptides

authors： Oh-ishi T,Shimoda T,Hayashi H,Onaga T

更新日期：2013-02-01 00:00:00

abstract：:The 36-amino-acid peptide, neuropeptide Y (NPY), is the most abundant peptide in the rat brain. When administered into the brain, NPY produces a variety of physiological actions including a pronounced stimulation of feeding in satiated rats. Elevations in hypothalamic NPY have been reported after food deprivation and ...

journal_title：Neuropeptides

authors： Gehlert DR

更新日期：1999-10-01 00:00:00

abstract：:Neuropeptide Y (NPY) has been implicated in the modulation of important features of neuronal physiology, including calcium homeostasis, neurotransmitter release and excitability. Moreover, NPY has been involved as an important modulator of hippocampal and thalamic circuits, receiving particular attention as an endogen...

journal_title：Neuropeptides

authors： Malva JO,Xapelli S,Baptista S,Valero J,Agasse F,Ferreira R,Silva AP

更新日期：2012-12-01 00:00:00

abstract：:Oxytocic peptides extracted from the brain and plasma of the brushtail possum, Trichosurus vulpecula, were separated by reverse-phase high pressure lipid chromatography (HPLC) and quantified by specific radioimmunoassays for oxytocin (OT) and mesotocin (MT). The pituitary, hypothalamus and cerebral cortex were found t...

journal_title：Neuropeptides

authors： Bathgate RA,Sernia C,Gemmell RT

更新日期：1990-07-01 00:00:00

abstract：:The role played by the biologically active CART 55-102 peptide in NAcc AMPH induced locomotion was investigated. When microinjected alone into this site, none of the doses of CART 55-102 tested (0.1, 0.4, 1.0 or 2.5 microg/0.5 microl/side) produced effects on locomotion during a two-h test. However, when co-injected w...

journal_title：Neuropeptides

authors： Kim JH,Creekmore E,Vezina P

更新日期：2003-12-01 00:00:00

abstract：:Abnormal aggregation of beta-amyloid (Aβ) peptide into amyloid plaques in the brain has been identified as one of the key factors in instigating AD pathogenesis. Inhibition of Aβ aggregation can be an important therapeutic strategy in disease management. In this work, we demonstrate the application of structure-based ...

journal_title：Neuropeptides

authors： Pandey G,Morla S,Kumar S,Ramakrishnan V

更新日期：2020-06-01 00:00:00

abstract：:Acid extracts from mouse Neuroblastoma x rat Glioma hybrid cells have been purified by means of Sep-Pak C-18 and fractionated by high performance liquid chromatography. Each fraction has been submitted to a sensitive beta-endorphin radioimmunoassay and an immunoreactivity peak at camel beta-endorphin retention time wa...

journal_title：Neuropeptides

authors： Di Marzo V,Etienne A,Marino G,Morris HR,Palmisano A

更新日期：1985-03-01 00:00:00

abstract：:The biological and immunological properties of insulin-like material produced by brain cells from 12 day old mice, cultured in serum-free media were examined. Differences were seen in the rate of appearance, relative amounts and behaviour on HPLC between immunoreactive and biologically active insulin-like material. Ex...

journal_title：Neuropeptides

authors： Birch NP,Christie DL,Renwick AG

更新日期：1987-05-01 00:00:00

abstract：:Highly purified porcine neurophysin-II, prepared from pig posterior pituitary lobe tissue was injected into fifteen rabbits in the preparation of anti-neurophysin sera. All antisera, when used in association with immunohistochemical procedures, gave an immunoreaction in structures of the rat hypothalamo-neurohypophysi...

journal_title：Neuropeptides

authors： Watkins WB

更新日期：1983-10-01 00:00:00

abstract：:Previous behavioural and electrophysiological studies have indicated an antinarcotic action of thyrotropin-releasing hormone (TRH) and its analogues in antagonizing the action of CNS depressant drugs, including baclofen and a variety of anesthetics. While beta-adrenergic receptors are implicated in the level of anaest...

journal_title：Neuropeptides

authors： Clarke KA,Djouhri L

更新日期：1991-09-01 00:00:00

abstract：:Peripheral neurons begin to express galanin after axotomy. When neurons in the superior cervical ganglion were axotomized near (about 2 mm) from the ganglion, galanin-like immunoreactivity (IR) was maximal within 72 h. Axotomy of neurons in the middle and inferior cervical ganglion complex (MICG), which could be perfo...

journal_title：Neuropeptides

authors： Shadiack AM,Zigmond RE

更新日期：1998-06-01 00:00:00

abstract：:Down syndrome is the most common genetic disorder associated with mental retardation. Subjects and mice models for Down syndrome (such as Ts65Dn) show defects in the formation of neuronal networks in both the hippocampus and the cerebral cortex. The principal neurons display alterations in the morphology, density and ...

journal_title：Neuropeptides

authors： Hernández S,Gilabert-Juan J,Blasco-Ibáñez JM,Crespo C,Nácher J,Varea E

更新日期：2012-02-01 00:00:00

abstract：:Amylin (AMY) is a member of calcitonin family of peptides. In this study, the effects of intrathecal (i.t) injection of AMY on the inflammatory pain and on the cAMP accumulation in the rat spinal cells were investigated. By using AMY receptor antagonists, we also studied the pharmacology of AMY receptors in the spinal...

journal_title：Neuropeptides

authors： Khoshdel Z,Takhshid MA,Owji AA

更新日期：2016-06-01 00:00:00

abstract：:Clinical and experimental evidence have demonstrated that, use of alcohol during pregnancy can interrupt brain development. Alcohol-induced neurocognitive deficits in offspring's are involved with activation of oxidative-inflammatory cascade joined with extensive apoptotic neurodegeneration in different brain regions ...

journal_title：Neuropeptides

authors： Toosi A,Shajiee H,Khaksari M,Vaezi G,Hojati V

更新日期：2019-04-01 00:00:00

abstract：:Proenkephalin peptides produced by endocrine and nervous tissues are involved in stress-induced immunosuppression. However, the role of peptides produced by immune cells remains unknown. The present study examines the effect of acute and chronic foot-shock stress on proenkephalin peptide content in bone marrow (BMMC),...

journal_title：Neuropeptides

authors： Saravia F,Padros MR,Ase A,Aloyz R,Duran S,Vindrola O

更新日期：1998-08-01 00:00:00

abstract：:The discriminative stimulus properties of the selective CCKB-receptor antagonist, L-365,260 were evaluated in rats trained to discriminate diazepam (2 mg/kg) or morphine (5 mg/kg) from vehicle, using a two-lever food reinforced technique. In the diazepam drug discrimination, the benzodiazepine-receptor agonist FG8205 ...

journal_title：Neuropeptides

authors： Jackson A,Tattersall D,Bentley G,Rycroft W,Bourson A,Hargreaves R,Tricklebank M,Iversen S

更新日期：1994-05-01 00:00:00

abstract：:Cocaine- and amphetamine-regulated transcript (CART) peptides have a wide CNS distribution and appear to play an important role in a number of physiological processes including reward and reinforcement, feeding, locomotion, stress responses and perception of pain. We have further investigated the expression of CART pe...

journal_title：Neuropeptides

authors： Press DA,Wall MJ

更新日期：2008-02-01 00:00:00

abstract：:Both endothelins and corticotropin releasing factor (CRF) appear in capsaicin-sensitive neurons. We have investigated the effects of human endothelin-1 (ET-1) and CRF in the guinea-pig ileum longitudinal and circular preparations and sought for ways of specific antagonism. With the aid of tachyphylaxis to capsaicin (i...

journal_title：Neuropeptides

authors： Lázár Z,Benkó R,Bölcskei K,Rumbus Z,Wolf M,Holzer P,Maggi CA,Barthó L

更新日期：2003-08-01 00:00:00

abstract：:The present study was undertaken to determine whether neurotensin is involved in the regulation of the intestinal postprandial motor response and, if so, whether the regulatory pathway depends upon peripheral or central neurotensin secretion. Neurotensin, injected by the i.v. route (5 micrograms/kg) during the fasting...

journal_title：Neuropeptides

authors： Pellissier S,Eribon O,Chabert J,Gully D,Roche M

更新日期：1996-10-01 00:00:00

abstract：:Neural stem cells (NSC) could promote the repair after spinal cord transection (SCT), the underlying mechanism, however, still keeps to be defined. This study reported that NSC grafts significantly improved sensory and locomotor functions in adult rats with SCT in acute stage after injury. NSC could survive; different...

journal_title：Neuropeptides

authors： He BL,Ba YC,Wang XY,Liu SJ,Liu GD,Ou S,Gu YL,Pan XH,Wang TH

更新日期：2013-02-01 00:00:00

abstract：:In vitro structure-activity studies with cholecystokinin (CCK)/gastrin-related peptides, including C- and N-terminal fragments of CCK 26-33, were undertaken in guinea pig gallbladder and ileum. The general order of potency in both smooth muscle preparations is CCK 26-33 greater than CCK 1-33 greater than 27-33 much mu...

journal_title：Neuropeptides

authors： Gaudreau P,St-Pierre S,Pert CB,Quirion R

更新日期：1987-07-01 00:00:00

abstract：:In an attempt to determine the localization of the messenger RNA (mRNA) encoding somatostatin in the rat retina, we studied Sprague-Dawley rats by in situ hybridization histochemistry using radiolabelled oligodeoxyribonucleotides complementary for rat somatostatin mRNA. Among the layers of retina, we found specific la...

journal_title：Neuropeptides

authors： Yamaguchi K,Gaur VP,Spira AW,Turner JE

更新日期：1990-09-01 00:00:00