Abstract：
:Oxytocic peptides extracted from the brain and plasma of the brushtail possum, Trichosurus vulpecula, were separated by reverse-phase high pressure lipid chromatography (HPLC) and quantified by specific radioimmunoassays for oxytocin (OT) and mesotocin (MT). The pituitary, hypothalamus and cerebral cortex were found to contain MT only in quantities of 3.9 +/- 0.2 (SE) ug, 17.6 +/- 0.6 ng and 21.0 +/- 2.6 ng respectively. The plasma concentration of MT varied according to the degree of stress of the possum. In anaesthetized animals values of 39.7 +/- 9.7 pg/ml (11 males) and 31.5 +/- 12.9 pg/ml (6 females) were obtained; in four conscious catheterized animals, 9.4 +/- 6.3 pg/ml. Samples taken from three anaesthetized animals during exsanguination contained 271 +/- 102 (SD) pg MT/ml. It was concluded that hypothalamic and extra-hypothalamic MT is present in the marsupial brain and that as in placental mammals, stress stimulates the secretion of mesotocin.
journal_name
Neuropeptidesjournal_title
Neuropeptidesauthors
Bathgate RA,Sernia C,Gemmell RTdoi
10.1016/0143-4179(90)90123-gsubject
Has Abstractpub_date
1990-07-01 00:00:00pages
121-7issue
3eissn
0143-4179issn
1532-2785pii
0143-4179(90)90123-Gjournal_volume
16pub_type
杂志文章相关文献
NEUROPEPTIDES文献大全abstract：:The action of corticotropin-releasing factor (CRF) is mediated by two recently identified receptors, CRFR1 and CRFR2, that differ with respect to their anatomical distribution and pharmacologic ligand-binding properties. Here we show by an analysis of circadian heartbeat interval fluctuations that CRFR2-deficiency in ...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/s0143-4179(02)00135-x
更新日期：2003-02-01 00:00:00
abstract：:The effects of intravenous self-administration of 30 micrograms infusions of either heroin or cocaine, or saline on the concentrations of beta-endorphin-immunoreactivity (beta E-IR) in the anterior part of the rat brain limbic system were studied. Self-administration of heroin and cocaine for 5 daily sessions resulted...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(88)90060-1
更新日期：1988-11-01 00:00:00
abstract：:Plasma protein extravasation in the upper airways of anesthetized guinea pigs was measured with the FITC (Fluorescein isothiocyanate)-dextran technique. The effect of selective tachykinin (NK1 and NK2) receptor agonists and antagonists, capsaicin or antigen was studied. The tachykinin NK1 receptor agonist, [Sar9]subst...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/s0143-4179(97)90022-6
更新日期：1997-02-01 00:00:00
abstract：:The effects of vasoactive intestinal peptide (VIP) on spatial cognitive deficits induced in the rat by injections of scopolamine were examined in a radial arm maze. A single intraperitoneal (i.p.), subcutaneous (s.c.) or intracerebroventricular (i.c.v.) injection of VIP inhibited the reduction in the number of initial...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(94)90124-4
更新日期：1994-03-01 00:00:00
abstract：:Cocaine- and amphetamine-regulated transcript (CART) peptides have a wide CNS distribution and appear to play an important role in a number of physiological processes including reward and reinforcement, feeding, locomotion, stress responses and perception of pain. We have further investigated the expression of CART pe...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/j.npep.2007.11.001
更新日期：2008-02-01 00:00:00
abstract：:Cocaine-regulated and amphetamine-regulated transcript (CART) is a neuropeptide with reported neuroprotective effects in ischemic cerebral injury. However, its mechanism has not yet been elucidated. Herein, we investigated the role and mechanism of CART in synaptic plasticity in neurons after ischemic cerebral stroke....
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/j.npep.2020.102023
更新日期：2020-06-01 00:00:00
abstract：:The relative roles of hypothalamic corticotropin-releasing-hormone (CRH) and vasopressin (AVP) as mediators of the stimulant effect of vasoactive intestinal peptide (VIP) and peptide histidine isoleucine (PHI) on ACTH and corticosterone (CORT) secretion, were examined using receptor blockade of endogenous CRH and AVP....
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(95)90112-4
更新日期：1995-03-01 00:00:00
abstract：:HPLC techniques were used to identify peptides that possess vasopressin-like immunoreactivity in the chicken neurohypophysis. The presence of arginine vasotocin (AVT) was confirmed together with arginine vasopressin (AVP). That the presence of AVP may be confined to the chicken, and not other avian species, was conclu...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(86)90045-4
更新日期：1986-08-01 00:00:00
abstract：:A series of analogues of substance P, where the Met11 residue was replaced by Glu(OCH2CH3), Glu(OBzl) and Hse(CH3), were synthesized in order to investigate the effect on agonist activity of modifications at the C-terminal residue. The biological activities in the guinea-pig ileum assay (NK1 receptor) and rat [text sa...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(94)90013-2
更新日期：1994-07-01 00:00:00
abstract：:Endomorphins are newly discovered mu-opioid receptor selective immunocompetent opioid peptides. Endomorphin 1 is predominantly distributed in brain, while endomorphin 2 is widely allocated in the spinal cord. Lately, endomorphins have been investigated as modulators of reactive oxygen and nitrogen species. Nitric oxid...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/j.npep.2009.11.004
更新日期：2010-02-01 00:00:00
abstract：:The neurokinin-1 (NK-1) receptor interacts with peptides that belong to the tachykinin family. NK-1 is inducible in bone marrow (BM) stroma. In neural cells, its expression is high to constitutive. Screening of three cDNA libraries indicated that this different in NK-1 expression in neural and BM cells could not be ex...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1054/npep.2002.0869
更新日期：2002-02-01 00:00:00
abstract：:The distribution of beta-endorphin (1-27) immunoreactive cell bodies and fibres was studied in the diencephalon of the cat using an indirect immunoperoxidase technique. In the thalamus, almost all the immunoreactive fibres were found in the midline region and in nuclei located near the midline, whereas in the hypothal...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/s0143-4179(96)90072-4
更新日期：1996-06-01 00:00:00
abstract：:Spermidine is a naturally occurring endogenous polyamine synthesized from diamine putrescine. It is a well-known autophagy inducer that maintains cellular and neuronal homeostasis. Healthy brain development and function are dependent on brain polyamine concentration. Polyamines interact with the opioid system, glutama...
journal_title：Neuropeptides
pub_type： 杂志文章,评审
doi：10.1016/j.npep.2020.102083
更新日期：2020-10-01 00:00:00
abstract：:The Third Galanin Symposium presented many different and exciting results on galanin research reflecting a major progress since the previous symposium in 1998. A major impression was the many possible relationships of galaninergic mechanisms to important brain functions such as development, cognition and ageing as wel...
journal_title：Neuropeptides
pub_type：
doi：10.1016/j.npep.2005.03.002
更新日期：2005-06-01 00:00:00
abstract：:Endothelins (ET) are a family of highly active neuropeptides with manifold influences via ET receptors (ETR) in both the peripheral and central nervous systems. We have shown previously that satellite glial cells (SGCs) in mouse trigeminal ganglia (TG) are extremely sensitive to ET-1 in evoking [Ca2+]in increase, appa...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/j.npep.2017.03.002
更新日期：2017-06-01 00:00:00
abstract：:Oxytocin (OXT), a nonapeptide hormone of posterior pituitary, reaches the central nervous system from systemic blood circulation with a difficulty because of the blood-brain barrier (BBB). The interest has been expressed in the use of the nasal route for delivery of OXT to the brain directly, exploiting the olfactory ...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/j.npep.2012.12.003
更新日期：2013-04-01 00:00:00
abstract：:We have previously shown that the kappa-opioid agonist, asimadoline, produces time-dependent changes in neuropeptide concentrations in the joints of rats with chronic arthritis. We hypothesized that asimadoline acts on peripheral terminals to modulate substance P (SP) release. To address this hypothesis, here we have ...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1054/npep.2000.0813
更新日期：2000-06-01 00:00:00
abstract：:Pituitary adenylate cyclase-activating polypeptide (PACAP-27) was incubated in a tyrosine hydroxylase (TyrOH) assay with a homogenate preparation of the nucleus accumbens of the rat. TyrOH activity was determined in vitro by measuring the production of L-dopa with HPLC-ECD. Only in the presence of adenosine nucleotide...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1054/npep.1999.0768
更新日期：1999-12-01 00:00:00
abstract：:Possible positive reinforcing and aversive effects of intraperitoneally (ip) administered substance P (SP) and its C-terminal heptapeptide analog [pGlu5, MePhe8, Sar9]-SP5-11 (DIME-C7) were investigated in rats. The 'conditioned corral preference and avoidance procedure' was used for assessing positive and negative re...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(90)90037-y
更新日期：1990-12-01 00:00:00
abstract：:The effects of thyroliberin (TRH), a TRH-like tripeptide colon mitosis inhibitor (CMI), a somatostatin analog SMS 201-995 and metoclopramide (dopamine receptor antagonist enhancing prolactin secretion) on rat thymus cell proliferation were investigated. The incorporation of bromodeoxyuridine (BrDU) into thymic cell nu...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(92)90123-e
更新日期：1992-11-01 00:00:00
abstract：:Neuropeptide Y (NPY) neurons abundantly innervate the hypothalamus, where NPY is involved in the regulation and integration of a broad range of homeostatic functions. In order to understand NPY-mediated behavioral, autonomic and neuroendocrine effects, it is important to characterize in detail the distribution of the ...
journal_title：Neuropeptides
pub_type： 杂志文章,评审
doi：10.1016/j.npep.2004.05.009
更新日期：2004-08-01 00:00:00
abstract：RATIONALE:Cholecystokinin and its analogs generate anxiety in humans and measurable anxiety-like behaviors in rats. Cholecystokinin receptor blockers have been reported to have variable effects in the treatment of anxiety disorders. We demonstrated that intracerebroventricular administration of Cholecystokinin-antisens...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/s0143-4179(02)00088-4
更新日期：2002-10-01 00:00:00
abstract：:The discriminative stimulus properties of the selective CCKB-receptor antagonist, L-365,260 were evaluated in rats trained to discriminate diazepam (2 mg/kg) or morphine (5 mg/kg) from vehicle, using a two-lever food reinforced technique. In the diazepam drug discrimination, the benzodiazepine-receptor agonist FG8205 ...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(94)90119-8
更新日期：1994-05-01 00:00:00
abstract：:In this study, we examined whether the mechanisms mediating the induction of grooming behavior by oxytocin (OT) is similar to mechanisms mediating the effects of OT on uterine contractility. Sprague-Dawley strain female rats were injected intracerebroventricularly (ICV) with OT or OT analogues and then were observed f...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(86)90068-5
更新日期：1986-07-01 00:00:00
abstract：:Injection of endothelin-1 (9 pmol) into the lateral cerebral ventricle of rats produced barrel-rotations, convulsions, tonic hindlimb extensions, facial clonus, and kinetic ataxia for up to 45 min. Quantitative metabolic autoradiographs produced from the [14C]deoxyglucose method and analyzed over 60 individual brain s...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(92)90025-r
更新日期：1992-04-01 00:00:00
abstract：:In equilibrium binding studies, using 3H-etorphine and 3H-diprenorphine, digitonin extracts of frog brain membranes are found to contain two classes of sites, one of which is seen only in the presence of Na+ ions. Centrifugation of the extracts in sucrose gradients separates two macromolecular components (10S and 12S)...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(84)90044-1
更新日期：1984-12-01 00:00:00
abstract：:The effects of several mu and kappa opioid receptor agonists on urinary excretion were examined in the water-loaded rat. Mu agonists induced anti-diuresis whereas kappa agonists caused diuresis. Furthermore, high efficacy kappa agonists eg. U50, 488H and tifluadom, produced marked diuretic effects, whereas kappa parti...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(85)90047-2
更新日期：1985-02-01 00:00:00
abstract：:Pyroglutamyl diazomethyl ketone and N-benzyloxycarbonyl prolyl prolinal, specific inhibitors of pyroglutamyl peptidase I and prolyl endopeptidase respectively, were used to study the possible role of these enzymes in the regulation of thyrotropin releasing hormone turnover. In vitro thyrotropin releasing hormone relea...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(87)90010-2
更新日期：1987-05-01 00:00:00
abstract：:During neonatal development exogenous oxytocin increases ERalpha immunoreactivity in the hypothalamus of female prairie voles. The purpose of this study was to determine if the increase in ERalpha is associated with an increase in ERalpha mRNA expression and to determine if the effect is specific to ER subtype or if o...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/j.npep.2006.10.002
更新日期：2007-02-01 00:00:00
abstract：:Brain insulin receptors adsorb to and are recoverable from wheat germ agglutinin-agarose (WGA) columns. Similar results are obtained using dissuccinimidyl suberate (DSS)-crosslinked receptors or photo-affinity labeled receptors. WGA can be used for partial purification of brain insulin receptors provided the appropria...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(87)90025-4
更新日期：1987-01-01 00:00:00
