Abstract:
:A series of analogues of substance P, where the Met11 residue was replaced by Glu(OCH2CH3), Glu(OBzl) and Hse(CH3), were synthesized in order to investigate the effect on agonist activity of modifications at the C-terminal residue. The biological activities in the guinea-pig ileum assay (NK1 receptor) and rat [text says rabbit] pulmonary artery (NK2 receptor) indicate that replacement of the SCH3 group of Met11 of substance P by the COOBzl or OCH3 groups favour interaction with the NK1 receptor and increase selectivity towards this receptor subtype.
journal_name
Neuropeptidesjournal_title
Neuropeptidesauthors
Poulos C,Antoniou M,Patacchini R,Maggi CA,Pegoraro S,Rovero Pdoi
10.1016/0143-4179(94)90013-2subject
Has Abstractpub_date
1994-07-01 00:00:00pages
27-9issue
1eissn
0143-4179issn
1532-2785pii
0143-4179(94)90013-2journal_volume
27pub_type
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