Differential response to a stress stimulus of proenkephalin peptide content in immune cells of naive and chronically stressed rats.

abstract：:AtT-20 cells are known to synthesize two molecular weight forms of the prohormone converting enzyme PC1 with molecular masses of 87 and 66 kDa. In this study we have analyzed basal and stimulated secretion of these proteins. Western blot results show that basal secretion medium of cultured AtT-20 cells contained low c...

journal_title：Neuropeptides

authors： Vindrola O,Lindberg I

更新日期：1993-08-01 00:00:00

abstract：:The relative roles of hypothalamic corticotropin-releasing-hormone (CRH) and vasopressin (AVP) as mediators of the stimulant effect of vasoactive intestinal peptide (VIP) and peptide histidine isoleucine (PHI) on ACTH and corticosterone (CORT) secretion, were examined using receptor blockade of endogenous CRH and AVP....

journal_title：Neuropeptides

authors： Alexander LD,Sander LD

更新日期：1995-03-01 00:00:00

abstract：:The aim of the present investigation was to determine if chronic activation of kappa-opioid receptor induces development of tolerance and dependence to kappa-opioid agonists on the isolated right atrium of the rat. Tolerance to the kappa-agonist was induced by chronic administration of U-50,488H, a selective kappa-ago...

journal_title：Neuropeptides

authors： Milanés MV,Rabadan JV,Laorden ML

更新日期：1997-10-01 00:00:00

abstract：:In our previous study we have identified PACAP, VIP and their receptors in rat malignant peripheral nerve sheath tumor (MPNST) cells, thus showing anti-apoptotic roles. Recently it has been shown that the tumor suppressor neurofibromin, encoded by the Neurofibromatosis type I (NF1) gene, promotes MPNST cells sensitivi...

journal_title：Neuropeptides

authors： Giunta S,Castorina A,Adorno A,Mazzone V,Carnazza ML,D'Agata V

更新日期：2010-02-01 00:00:00

abstract：:Peripheral neurons begin to express galanin after axotomy. When neurons in the superior cervical ganglion were axotomized near (about 2 mm) from the ganglion, galanin-like immunoreactivity (IR) was maximal within 72 h. Axotomy of neurons in the middle and inferior cervical ganglion complex (MICG), which could be perfo...

journal_title：Neuropeptides

authors： Shadiack AM,Zigmond RE

更新日期：1998-06-01 00:00:00

abstract：:Morphine (M) produced a dose-related decrease in metabolic weight loss (MWL) over a three-hour period, despite the fact that it significantly enhanced locomotor activity in male mice. This conservation of energy was specific to opioid receptors because naltrexone HCl (N) blocked it. These receptors were localized main...

journal_title：Neuropeptides

authors： Henry LJ,Walker J,Margules DL

更新日期：1985-02-01 00:00:00

abstract：:In previous studies, membranes from chicken gastrointestinal tissues failed to bind appreciable levels of 125I-APP labeled at the C-terminus. In order to address the suggestion that this was due to steric hindrance of the critical C-terminus, N-terminally labeled 125I-APP was utilized in in vitro membrane binding assa...

journal_title：Neuropeptides

authors： Adamo ML,Hazelwood RL

更新日期：1992-04-01 00:00:00

abstract：:Oxytocic peptides extracted from the brain and plasma of the brushtail possum, Trichosurus vulpecula, were separated by reverse-phase high pressure lipid chromatography (HPLC) and quantified by specific radioimmunoassays for oxytocin (OT) and mesotocin (MT). The pituitary, hypothalamus and cerebral cortex were found t...

journal_title：Neuropeptides

authors： Bathgate RA,Sernia C,Gemmell RT

更新日期：1990-07-01 00:00:00

abstract：:125I-Neuropeptide Y (NPY) bound specifically with high affinity to rat atrial and ventricular membranes. Scatchard analysis revealed the presence of single class of binding sites in both atrial and ventricular membranes. The apparent Kd and Bmax for atrial membranes were 0.63 nM and 70 fmol/mg protein, respectively; v...

journal_title：Neuropeptides

authors： Sheriff S,Rigel DF,Fischer JE,Balasubramaniam A

更新日期：1990-03-01 00:00:00

abstract：:Intravenous injections of neurotensin (NT) (0.5, 1 and 2 nmoles kg-1) evoked dose-dependent increases in histaminemia and hematocrit, and marked hypotensive effect, in anesthetized rats. The increase of plasma histamine was rapid in onset (within sec), peak plasma histamine being reached in less than 2 min. The declin...

journal_title：Neuropeptides

authors： Kérouac R,St-Pierre S,Rioux F

更新日期：1982-12-01 00:00:00

abstract：:The effects of several protein modifying reagents, including phenoxybenzamine, N-ethylmaleimide (NEM), 5,5'-dithiobis (2-nitro)--benzoic acid (DTNB), p-chloromercuryphenyl sulfonic acid (PCMP) and p-bromophenacylbromide (PBPB), on the binding of 125I-Bolton Hunter substance P (125I-BHSP), 125I-Bolton Hunter eledoisin ...

journal_title：Neuropeptides

authors： Bergström L,Beaujouan JC,Torrens Y,Saffroy M,Glowinski J

更新日期：1987-02-01 00:00:00

abstract：OBJECTIVE:Potential physiological correlates of stress and the role of stress neuropeptides, other than those of the hypothalamic-pituitary-adrenal axis, in critical illness have not been addressed. We investigated: (a) serum levels of stress neuropeptides (ACTH, substance P (SP), neuropeptide Y (NPY), cortisol, prolac...

journal_title：Neuropeptides

authors： Mpouzika MD,Papathanassoglou ED,Giannakopoulou M,Bozas E,Middleton N,Boti S,Patiraki EI,Karabinis A

更新日期：2013-02-01 00:00:00

abstract：:Quantitative evaluation of octadecaneuropeptide-like immunoreactivity (ODN-Li) was carried out in hippocampus, cortex and cerebellum of group-reared or three month isolated male Wistar rats, whether muricidal or not. ODN-Li was lower in cortex and cerebellum of isolated animals, (mainly in muricidal) than of group-rea...

journal_title：Neuropeptides

authors： Miachon S,Tonon MC,Vaudry H,Buda M

更新日期：1991-07-01 00:00:00

abstract：:Neuropeptide Y (NPY) is known to bind to at least two types of receptors (Y1 & Y2). One type (Y2) is able to bind and undergo activation by both NPY and its C-terminal fragments with good potency while the other (Y1) requires the full length of NPY for good potency. For most NPY analogs that have been examined, potenc...

journal_title：Neuropeptides

authors： Krstenansky JL,Owen TJ,Payne MH,Shatzer SA,Buck SH

更新日期：1990-11-01 00:00:00

abstract：:3H-Bradykinin binding sites with the characteristics of receptors were identified in homogenates of bovine hippocampus and PC-12 cells. The characteristics of the binding were similar in both types of tissue and paralleled those of the B2 bradykinin receptor. Following exposure to nerve growth factor for 72 hours, the...

journal_title：Neuropeptides

authors： Kozlowski MR,Rosser MP,Hall E

更新日期：1988-11-01 00:00:00

abstract：:Since there are conflicting reports regarding the effects of somatostatin (SS) on cyclic AMP levels in astrocytes derived from rat cerebral cortex and, to date, the SS binding to mature astrocytes is unknown, the present study has determined SS binding and its effect on cyclic AMP accumulation in a fresh astrocyte-ric...

journal_title：Neuropeptides

authors： Colás B,Arilla E,Prieto JP

更新日期：1992-09-01 00:00:00

abstract：:Enkephalin-immunoreactive neurons have been identified in the central nervous system of the fruit fly Drosophila melanogaster by immunocytochemical techniques. Analyses of fly extracts by high performance liquid chromatography and radioimmunoassay show a relatively complex pattern of immunoreactive compounds. The most...

journal_title：Neuropeptides

authors： Pagés M,Jiménez F,Ferrús A,Peralta E,Ramírez G,Gelpí E

更新日期：1983-12-01 00:00:00

abstract：:The orally active, α-hemoglobin derived hemopressin (PVNFKFLSH, Hp(1-9)) and its truncated (PVNFKFL, Hp(1-7) and PVNFKF, Hp(1-6)) and extended ((R)VDPVNFKFLSH, VD-Hp(1-9) and RVD-Hp(1-9)) derivatives have been postulated to be the endogenous peptide ligands of the cannabinoid receptor type 1 (CB1). In an attempt to cr...

journal_title：Neuropeptides

authors： Dvorácskó S,Tömböly C,Berkecz R,Keresztes A

更新日期：2016-08-01 00:00:00

abstract：:Immunohistochemical tests have demonstrated for the first time the presence of endothelins in the neuroendocrine cells of fish gill. We have sought co-localization of endothelins with serotonin and neuropeptides which are regarded as neuroendocrine markers of pulmonary diffuse neuroendocrine systems in higher vertebra...

journal_title：Neuropeptides

authors： Zaccone G,Mauceri A,Fasulo S,Ainis L,Lo Cascio P,Ricca MB

更新日期：1996-02-01 00:00:00

abstract：:A human brain aminopeptidase, which hydrolyses low molecular weight enkephalin-containing peptides (ECPs), was purified to apparent homogeneity from the homogenate of human brain. The enzyme purification involved DEAE-cellulose chromatography and preparative polyacrylamide gel electrophoresis. The purified aminopeptid...

journal_title：Neuropeptides

authors： Duarte GI,Souza FG,Bruno JA,Camargo AC,Carvalho KM

更新日期：1988-08-01 00:00:00

abstract：:Available data concerning the effect of oxytocin on memory are often inconsistent. In the present study it was found that oxytocin, intracerebroventricularly injected to adult male rats in a dose range of 1 fg-10 ng/rat immediately after a 5-minute encounter with a juvenile, significantly reduces the social investigat...

journal_title：Neuropeptides

authors： Benelli A,Bertolini A,Poggioli R,Menozzi B,Basaglia R,Arletti R

更新日期：1995-04-01 00:00:00

abstract：:Nerve growth factor (NGF) was reported to be increased in the serum and skin of atopic dermatitis (AD) patients, to the extent that serum nerve growth factor levels were proposed to serve as a marker of disease severity. We studied NGF levels in the serum and dermis using skin microdialysis and attempted to correlate ...

journal_title：Neuropeptides

authors： Papoiu AD,Wang H,Nattkemper L,Tey HL,Ishiuji Y,Chan YH,Schmelz M,Yosipovitch G

更新日期：2011-12-01 00:00:00

abstract：:The present study was planned to evaluate role of tachykinins (TKs) and neurokinin (NK) receptors in the regulation of gastric motility in sheep. We examined the effects of intravenous (i.v.) injection of neurokinin A (NKA) and substance P (SP) on motility of the rumen, omasum, and abomasum in conscious sheep and the ...

journal_title：Neuropeptides

authors： Oh-ishi T,Shimoda T,Hayashi H,Onaga T

更新日期：2013-02-01 00:00:00

abstract：:The distribution of beta-endorphin (1-27) immunoreactive cell bodies and fibres was studied in the diencephalon of the cat using an indirect immunoperoxidase technique. In the thalamus, almost all the immunoreactive fibres were found in the midline region and in nuclei located near the midline, whereas in the hypothal...

journal_title：Neuropeptides

authors： Coveñas R,de León M,Narváez JA,Tramu G,Aguirre JA,González-Barón S

更新日期：1996-06-01 00:00:00

abstract：:This study found that dynorphin had a biphasic concentration response relationship on N-methyl-D-aspartate (NMDA) receptor-mediated currents in the CA3 region of the guinea pig hippocampal slice. A previous study demonstrated that the inhibitory effect was mediated by a kappa 2 opioid receptor. In the present study, t...

journal_title：Neuropeptides

authors： Caudle RM,Dubner R

更新日期：1998-02-01 00:00:00

abstract：:The effects of 6-hydroxydopamine (6-OHDA) injected into either the ventral tegmental area (VTA) or the nucleus accumbens on dopamine and its metabolite DOPAC and CCK-immunoreactivity in the nucleus accumbens were studied. Measurements were made 1, 3 and 6 weeks after the lesion in both the anterior and posterior part ...

journal_title：Neuropeptides

authors： Igarashi Y,Wiegant VM,Van Ree JM

更新日期：1989-08-01 00:00:00

abstract：:Brain insulin receptors adsorb to and are recoverable from wheat germ agglutinin-agarose (WGA) columns. Similar results are obtained using dissuccinimidyl suberate (DSS)-crosslinked receptors or photo-affinity labeled receptors. WGA can be used for partial purification of brain insulin receptors provided the appropria...

journal_title：Neuropeptides

authors： Shemer J,LeRoith D

更新日期：1987-01-01 00:00:00

abstract：:Bombesin (BN) and its mammalian counterpart gastrin-releasing peptide act as neuroregulatory hormones and tissue-specific growth factors, and have been implicated as peripheral and central satiety-inducing agents. In the present study, the immunohistochemical expression of BN in submandibular, sublingual and parotid g...

journal_title：Neuropeptides

authors： Aalto Y,Kjörell U,Henriksson R,Franzén L,Forsgren S

更新日期：1997-04-01 00:00:00

abstract：:We have evaluated the peripheral blood natural killer (NK) cell activity and the in vitro effect of recombinant gamma-interferon (r gamma-IFN) on NK cell activity in 23 patients with a neuroendocrine tumour of the pancreas, small intestine or liver, and 23 healthy controls. Patients with a gastrinoma showed a NK cell ...

journal_title：Neuropeptides

authors： Aparicio-Pagés MN,Verspaget HW,Peña AS,Jansen JB,Lamers CB

更新日期：1991-09-01 00:00:00

abstract：:Neuropeptide Y (NPY) has been implicated in the modulation of important features of neuronal physiology, including calcium homeostasis, neurotransmitter release and excitability. Moreover, NPY has been involved as an important modulator of hippocampal and thalamic circuits, receiving particular attention as an endogen...

journal_title：Neuropeptides

authors： Malva JO,Xapelli S,Baptista S,Valero J,Agasse F,Ferreira R,Silva AP

更新日期：2012-12-01 00:00:00