Abstract：
:Nerve growth factor (NGF) was reported to be increased in the serum and skin of atopic dermatitis (AD) patients, to the extent that serum nerve growth factor levels were proposed to serve as a marker of disease severity. We studied NGF levels in the serum and dermis using skin microdialysis and attempted to correlate them with disease severity. We also examined if potential differences between morning and evening levels of NGF can explain the phenomenon of nocturnal itch. In addition, neurogenic inflammation and itch were induced using histamine iontophoresis in lesional and non-lesional skin and the effect of experimental itch on dermal NGF concentration was examined. We found that systemic (serum) and eczematous skin levels of NGF in AD are significantly lower in comparison to healthy controls. Serum NGF decreases from morning to late afternoon in both groups. Interestingly, serum NGF levels were correlated to disease severity in the morning in AD, although the NGF concentration in AD were significantly lower than in the healthy group. The local itch and neurogenic inflammation induction via experimental histamine reduced local NGF levels in the eczema and non-lesional skin in atopics, but not in the healthy controls, where it was slightly increased. The higher the clinical severity of the eczema, a significantly less pronounced effect of neurogenic inflammation on the local levels of NGF was found. The availability of measurable NGF might be reduced by a higher expression of NGF receptors. The fluctuations of NGF levels during the day suggest a complex modulation of this neurotrophin, potentially linked to stress or to an altered neurophysiological mechanism.
journal_name
Neuropeptidesjournal_title
Neuropeptidesauthors
Papoiu AD,Wang H,Nattkemper L,Tey HL,Ishiuji Y,Chan YH,Schmelz M,Yosipovitch Gdoi
10.1016/j.npep.2011.07.008subject
Has Abstractpub_date
2011-12-01 00:00:00pages
417-22issue
6eissn
0143-4179issn
1532-2785pii
S0143-4179(11)00069-2journal_volume
45pub_type
杂志文章相关文献
NEUROPEPTIDES文献大全abstract：:Spermidine is a naturally occurring endogenous polyamine synthesized from diamine putrescine. It is a well-known autophagy inducer that maintains cellular and neuronal homeostasis. Healthy brain development and function are dependent on brain polyamine concentration. Polyamines interact with the opioid system, glutama...
journal_title：Neuropeptides
pub_type： 杂志文章,评审
doi：10.1016/j.npep.2020.102083
更新日期：2020-10-01 00:00:00
abstract：:Fracture repair is a complex yet well orchestrated regenerative process involving numerous signaling and cell types including osteoblasts. Here we showed that NPY, a neurotransmitter with regulatory functions in bone homeostasis, may contribute to the post-fracture bone healing in patients with traumatic brain injury-...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/j.npep.2016.09.005
更新日期：2016-12-01 00:00:00
abstract：:Inoculation of rats at the tail-base with Mycobacterium led to arthritic swelling and inflammation of all four limbs. Immunoreactive (ir)-dynorphin (DYN) increased in anterior but not neurointermediate pituitary. In the brain, only thalamus showed a rise and, in spinal cord, a large elevation was seen. Ir-vasopressin ...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(85)90044-7
更新日期：1985-02-01 00:00:00
abstract：:Alarin is a newly identified member of the galanin family of neuropeptides that includes galanin-like peptide (GALP) and galanin. Alarin was discovered as an alternate transcript of the GALP gene in neuroblastoma cells, and subsequently alarin mRNA was detected in the brain of rodents. GALP and galanin are important c...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/j.npep.2010.04.001
更新日期：2010-08-01 00:00:00
abstract：:Rats housed individually for 7 days showed a marked decrease in motor activity when tested under intense light conditions in a novel environment as compared to group-housed rats tested under low light conditions. The ACTH analogue ORG 2766 administered into the amygdala decreased the motor activity of group-housed rat...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(89)90070-x
更新日期：1989-08-01 00:00:00
abstract：:In situ hybridisation histochemistry was used to study the effect of intra-peritoneal reserpine administration on messenger RNA (mRNA) levels in the locus coeruleus (LC) of the rat. 48h after injection, levels of mRNA encoding tyrosine hydroxylase (TH) and neuropeptide Y (NPY) in the LC increased to approximately 250%...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(91)90105-r
更新日期：1991-03-01 00:00:00
abstract：:CSF methionine and leucine enkephalins were measured by high performance liquid chromatography and radioimmunoassay in diabetic patients with painful neuropathy (n = 22) and painless neuropathy (n = 5), and non-diabetic subjects with low back pain (n = 11). Wide variations in CSF enkephalin levels were found and they ...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(92)90067-7
更新日期：1992-06-01 00:00:00
abstract：:Abnormal aggregation of beta-amyloid (Aβ) peptide into amyloid plaques in the brain has been identified as one of the key factors in instigating AD pathogenesis. Inhibition of Aβ aggregation can be an important therapeutic strategy in disease management. In this work, we demonstrate the application of structure-based ...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/j.npep.2020.102030
更新日期：2020-06-01 00:00:00
abstract：:Neuromedin U (NMU), a neuropeptide implicated in feeding, inflammation, pain control and anxiety-related behaviours, is widely distributed in peripheral organs and the CNS. These effects are thought to be mediated by its receptors NMU(1) and NMU(2). Since its precise sites of interaction in the CNS were to date unknow...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/j.npep.2008.04.008
更新日期：2008-08-01 00:00:00
abstract：:Stretching-yawning syndrome (SYS) and penile erections (PE) are typical components of the behavioral picture induced by intracerebroventricular (i.c.v.) injection of ACTH 1-24. The present study shows that pretreatment with alpha-difluoromethylornithine (DFMO), and irreversible inhibitor of mammalian ornithine decarbo...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(84)90105-7
更新日期：1984-05-01 00:00:00
abstract：:The effects of vasoactive intestinal peptide (VIP) on spatial cognitive deficits induced in the rat by injections of scopolamine were examined in a radial arm maze. A single intraperitoneal (i.p.), subcutaneous (s.c.) or intracerebroventricular (i.c.v.) injection of VIP inhibited the reduction in the number of initial...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(94)90124-4
更新日期：1994-03-01 00:00:00
abstract：:Orexins/hypocretins are neuropeptides that have various physiological effects, including the regulation of feeding behavior, neuroendocrine functions and sleep-wake cycles. Recent studies have suggested that the orexin system may also be involved in brain ischemic reactions. It is also known that changes in sleep patt...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/j.npep.2006.06.003
更新日期：2006-08-01 00:00:00
abstract：:In vitro structure-activity studies with cholecystokinin (CCK)/gastrin-related peptides, including C- and N-terminal fragments of CCK 26-33, were undertaken in guinea pig gallbladder and ileum. The general order of potency in both smooth muscle preparations is CCK 26-33 greater than CCK 1-33 greater than 27-33 much mu...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(87)90084-9
更新日期：1987-07-01 00:00:00
abstract：:Glucagon-like peptide-1 (7-36)-amide (GLP-1) is a gut peptide, which exerts significant effects on glucose homeostasis. GLP-1 and GLP-1 receptors are also widely distributed in the central nervous system. In the present study, we aimed to investigate the effects of intracerebroventricularly (i.c.v.)-injected GLP-1 on ...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/j.npep.2010.02.002
更新日期：2010-08-01 00:00:00
abstract：:This study found that dynorphin had a biphasic concentration response relationship on N-methyl-D-aspartate (NMDA) receptor-mediated currents in the CA3 region of the guinea pig hippocampal slice. A previous study demonstrated that the inhibitory effect was mediated by a kappa 2 opioid receptor. In the present study, t...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/s0143-4179(98)90022-1
更新日期：1998-02-01 00:00:00
abstract：:Oxytocin, intraperitoneally injected to 26-month-old male rats 60 min before testing, significantly improved social memory (at doses of 3 and 6 ng/kg) and reduced the duration of immobility in the behavioral despair test (at doses of 50 and 500 micrograms/kg). These results are in agreement with previous data obtained...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(95)90021-7
更新日期：1995-09-01 00:00:00
abstract：:Social recognition is the sensitive domains of complex behavior critical for identification, interpretation and storage of socially meaningful information. Social recognition develops throughout childhood and adolescent, and is affected in a wide variety of psychiatric disorders. Recently, new data appeared on the mol...
journal_title：Neuropeptides
pub_type： 杂志文章,评审
doi：10.1016/j.npep.2018.09.003
更新日期：2018-12-01 00:00:00
abstract：:Somatostatin is a neuropeptide that in several experimental models of epilepsy has been suggested to modulate epileptic activity. The purpose of the present study was to investigate the role of somatostatin in seizure phenomena. We measured the somatostatin-like immunoreactivity (SLI) by radioimmunoassay of the cister...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(87)90027-8
更新日期：1987-01-01 00:00:00
abstract：:Bone cancer pain (BCP) is a common source of pain in patients with advanced stage and metastatic cancer; however, existing treatment for this kind of pain remains deficient. Being closely related to sensory change and inflammatory pain in both the central and peripheral nervous systems, endothelin A receptor (ETAR) pl...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/j.npep.2018.01.003
更新日期：2018-04-01 00:00:00
abstract：:Levels of beta-endorphin immunoreactive material (IRM) in cerebrospinal fluid (CSF) have been reported to correlate inversely with postoperative morphine requirement. Considering proopiomelanocortin (POMC) derivatives as predictors for sensitivity to postoperative pain, we determined authentic beta-endorphin (beta-end...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/j.npep.2005.10.001
更新日期：2006-02-01 00:00:00
abstract：:The effects of the GABAergic drugs nipecotic acid, Gabrene, baclofen and metatolylcarbamide (MTC), when given alone or in combination at subthreshold doses with AT II also at a subthreshold dose effective on PTZ-kindling in mice were studied. PTZ-kindling was provoked by intraperitoneal (i.p.) injections of PTZ (40 mg...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(95)90071-3
更新日期：1995-01-01 00:00:00
abstract：:Procolipase is secreted as a protein consisting of 101 amino acids. In the intestinal lumen, procolipase is activated by trypsin and cleaves to form the active colipase and the pentapeptide from the amino terminus. This pentapeptide is called enterostatin. Pancreatic procolipase synthesis is stimulated by a high-fat d...
journal_title：Neuropeptides
pub_type： 杂志文章,评审
doi：10.1054/npep.1999.0052
更新日期：1999-10-01 00:00:00
abstract：:Neuropeptide Y (NPY) has been implicated in the modulation of important features of neuronal physiology, including calcium homeostasis, neurotransmitter release and excitability. Moreover, NPY has been involved as an important modulator of hippocampal and thalamic circuits, receiving particular attention as an endogen...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/j.npep.2012.09.001
更新日期：2012-12-01 00:00:00
abstract：BACKGROUND:Chromogranin A (CgA) in plasma (P-CgA), a neuroendocrine marker of sympathetic stress, has been shown to predict mortality in medical intensive care. We hypothesized that the magnitude of CgA release would reflect stress load, and thereby injury severity in burn intensive care patients. METHODS:Fifty-one co...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/j.npep.2012.10.004
更新日期：2013-06-01 00:00:00
abstract：:Cholecystokinin (CCK) is co-localized with dopamine (DA) in mesolimbic neurons of the CNS and appears to selectively regulate the output of this system. In an attempt to characterize the nature of CCK interactions with mesolimbic DA-containing nerve terminals, we have investigated CCK regulation of [3H]DA overflow fro...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(89)90020-6
更新日期：1989-01-01 00:00:00
abstract：:Perivascular sensory nerves release calcitonin gene-related peptide (CGRP) and substance P, the dilator actions of which can be regulated by nitric oxide (NO). This study investigated the role of NO in the vasodilation caused by sensory nerve stimulation, by capsaicin, or exogenous CGRP and substance P in the isolated...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/s0143-4179(97)90068-8
更新日期：1997-08-01 00:00:00
abstract：:Social conflict and defeat in mice leads to an activation of endogenous opiate systems. The effects of intracerebroventricular administration of the peptide FMRFamide (Phe-Met-Arg-Phe-NH2) and the opiate antagonist naloxone, on aggressive encounters, defeat-induced analgesia and defeat-induced feeding were examined in...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/0143-4179(85)90110-6
更新日期：1985-12-01 00:00:00
abstract：:The regulation of neuropeptide gene expression and their receptors in a tissue specific and stimulus inducible manner will determine in part behaviour and physiology. This can be a dynamic process resulting from short term changes in response to the environment or long term modulation imposed by epigenetically determi...
journal_title：Neuropeptides
pub_type： 杂志文章,评审
doi：10.1016/j.npep.2013.10.003
更新日期：2013-12-01 00:00:00
abstract：:Alzheimer's disease (AD) is a progressive neurodegenerative disease that deeply affects patients, their family and society. Although scientists have made intense efforts in seeking the cure for AD, no drug available today is able to stop AD progression. In this context, compounds isolated from animal venom are potenti...
journal_title：Neuropeptides
pub_type： 杂志文章,评审
doi：10.1016/j.npep.2017.11.010
更新日期：2018-02-01 00:00:00
abstract：:Peripheral neurons begin to express galanin after axotomy. When neurons in the superior cervical ganglion were axotomized near (about 2 mm) from the ganglion, galanin-like immunoreactivity (IR) was maximal within 72 h. Axotomy of neurons in the middle and inferior cervical ganglion complex (MICG), which could be perfo...
journal_title：Neuropeptides
pub_type： 杂志文章
doi：10.1016/s0143-4179(98)90045-2
更新日期：1998-06-01 00:00:00
