Abstract:
:Orexins/hypocretins are neuropeptides that have various physiological effects, including the regulation of feeding behavior, neuroendocrine functions and sleep-wake cycles. Recent studies have suggested that the orexin system may also be involved in brain ischemic reactions. It is also known that changes in sleep patterns, energy homeostasis and neuroendocrine functions are often occur in neurological conditions associated brain ischemia. In the current study, we investigated the time-dependent changes in cerebrospinal fluid (CSF) orexin-A concentration and the expression of the orexin-1 receptor (OX1R) in the rat hippocampus after global ischemia-reperfusion (5 min cardiopulmonary arrest), which is known to induce delayed cell death in the CA1 region of the hippocampus. The CSF orexin-A concentration was elevated transiently at 24 h after ischemia. On days 2 and 4 after ischemia, CSF orexin concentrations were significantly reduced relative to the baseline, and returned to the baseline level by day 7. These changes were correlated with increased expression of OX1R in the CA1 on days 1 and 2 post-ischemia. These results suggest that dynamics of orexin signaling observed may have functional roles for neuronal damage associated with transient ischemia.
journal_name
Neuropeptidesjournal_title
Neuropeptidesauthors
Dohi K,Nishino S,Nakamachi T,Ohtaki H,Morikawa K,Takeda T,Shioda S,Aruga Tdoi
10.1016/j.npep.2006.06.003subject
Has Abstractpub_date
2006-08-01 00:00:00pages
245-50issue
4eissn
0143-4179issn
1532-2785pii
S0143-4179(06)00047-3journal_volume
40pub_type
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